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BCRP inhibitor

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Catalog No. A11475

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ko-143 5mg A11475-5
Ko-143 10mg A11475-10
Ko-143 25mg A11475-25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ko 143 is potent and selective inhibitor of breast cancer resistance protein multidrug transporter (BCRP) with an EC90 value of 26 nM.


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Chemical Information

Catalog Num A11475
Actions Inhibitor
M. Wt 469.59
Formula C26H35N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 461054-93-3
Synonyms Ko 143,Ko143
SMILES code O=C1N2[[email protected]@H](CC(C)C)C(NC3=C4C=CC(OC)=C3)=C4C[[email protected]@H]2C(N[[email protected]@H]1CCC(OC(C)(C)C)=O)=O
Chemical Name tert-butyl 3-((3R,6S,12aR)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate

Biological Activity

Ko 143 is potent and selective inhibitor of breast cancer resistance protein multidrug transporter (BCRP) with an EC90 value of 26 nM.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.48 mL 212.95mL
0.5 mM 4.26 mL 21.3 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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