KY216

Catalog No.: A32882
Tubulin Polymerization Inhibitor
KY216 is a potent tubulin polymerization inhibitor that targets the colchicine-binding site of tubulin, with an IC50 value of 2.61 μM. This compound demonstrates significant biological activity in hindering tubulin polymerization, making it a valuable tool for research applications in non-small cell lung cancer (NSCLC) and breast cancer studies. KY216's mechanism of action positions it as a promising candidate for further investigation into therapeutic strategies against these malignancies.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKY216 is a potent tubulin polymerization inhibitor that targets the colchicine-binding site of tubulin, with an IC50 value of 2.61 μM. This compound demonstrates significant biological activity in hindering tubulin polymerization, making it a valuable tool for research applications in non-small cell lung cancer (NSCLC) and breast cancer studies. KY216's mechanism of action positions it as a promising candidate for further investigation into therapeutic strategies against these malignancies.
Product Information
Catalog NumA32882
FormulaC20H16Cl2N2O5
Molecular Weight435.26
CAS Number2804026-81-9
SMILESO=C(N1[C@@H](C2=CC3=C(C=C2C[C@H]14)OCCO3)C5=CC(Cl)=C(C(Cl)=C5)OC)NC4=O
SynonymsTubulin polymerization-IN-41
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