L-732138 is a selective and potent antagonist of the neurokinin-1 (NK-1) receptor, exhibiting an IC50 of 2.3 nM. This compound demonstrates a 200-fold greater potency in cloned human NK-1 receptors compared to cloned rat NK-1 receptors, and is more than 1000-fold more selective than human NK-2 and NK-3 receptors. L-732138 is useful in research focused on pain modulation, particularly in the reduction of hyperalgesia, and has shown potential antitumor activity.
L-732138 is a selective and potent antagonist of the neurokinin-1 (NK-1) receptor, exhibiting an IC50 of 2.3 nM. This compound demonstrates a 200-fold greater potency in cloned human NK-1 receptors compared to cloned rat NK-1 receptors, and is more than 1000-fold more selective than human NK-2 and NK-3 receptors. L-732138 is useful in research focused on pain modulation, particularly in the reduction of hyperalgesia, and has shown potential antitumor activity.
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