Largazole is a potent and selective Class I HDAC inhibitor, primarily targeting HDAC2 with an IC50 of 0.07 nM. Isolated from marine cyanobacteria, Largazole demonstrates significant antitumor activity against glioblastoma cell lines, including SF-268, SF-295, and SH-SY5Y, with IC50 values ranging from 62 to 102 nM. In addition to its antitumor properties, Largazole enhances the expression of key neuroprotective factors such as brain-derived neurotrophic factor (BDNF) and the transcription factor Pax6, making it a valuable reagent for research in glioblastoma and Alzheimer's disease.
Largazole is a potent and selective Class I HDAC inhibitor, primarily targeting HDAC2 with an IC50 of 0.07 nM. Isolated from marine cyanobacteria, Largazole demonstrates significant antitumor activity against glioblastoma cell lines, including SF-268, SF-295, and SH-SY5Y, with IC50 values ranging from 62 to 102 nM. In addition to its antitumor properties, Largazole enhances the expression of key neuroprotective factors such as brain-derived neurotrophic factor (BDNF) and the transcription factor Pax6, making it a valuable reagent for research in glioblastoma and Alzheimer's disease.
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