LGB-321 HCl

Catalog No.: A14420

Pan-PIM kinase inhibitor

LGB-321 HCl

LGB-321 HCl Chemical Structure

CAS NO. 1469925-36-7

LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).

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Package Price Qty
5 mg
$350.00
10 mg
$600.00
25 mg
$1,200.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Andrea L. Casillas, .et al. Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents, Clin Cancer Res, 2018, Jan 1; 24(1): 169-180 PMID: 29084916

Biological Activity

LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.25 mL 101.23 mL 202.47 mL
0.5 mM 4.05 mL 20.25 mL 40.49 mL
1 mM 2.02 mL 10.12 mL 20.25 mL
5 mM 0.4 mL 2.02 mL 4.05 mL

*The above data is based on the productmolecular weight 493.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14420
Actions Inhibitor
CAS No. 1469925-36-7
Formula C23H23ClF3N5O2
M. Wt 493.91
Purity >98%
Synonyms LGB-321, LGB321, LGB 321
SMILES O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C(N4C[[email protected]@H](N)[[email protected]](O)[[email protected]@H](C)C4)C=CN=C3.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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