Fig. 1 · Structure
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Lifirafenib hydrochloride
Cat. No.
A73200
CAS
2025320-97-0
Endogenous Metabolite
Lifirafenib hydrochloride is a reversible inhibitor of the B-RAFV600E mutation, exhibiting significant antitumor activity in solid tumors, including melanoma, thyroid cancer, and low-grade serous ovarian cancer. This compound demonstrates selective cytotoxicity by preferentially targeting cancer cells harboring B-RAFV600E and EGFR mutations or amplifications. In preclinical studies, Lifirafenib has been shown to inhibit tumor growth in a dose-dependent manner, resulting in partial and complete tumor regression in animal models, making it a valuable tool for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2025320-97-0 |
| Applications | Endogenous Metabolite |
| Formula | C25H18ClF3N4O3 |
| Molecular Weight | 514.88 |
| Synonyms | BGB-283 hydrochloride |
| SMILES | O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.