Lubiprostone (hemiketal)

Catalog No.: A66533
CLCN2 Activator
Lubiprostone (hemiketal) is a selective activator of chloride channel 2 (CLCN2). It effectively increases chloride ion secretion in the intestine, enhancing fluid secretion and promoting intestinal peristalsis, making it valuable for studying chronic idiopathic constipation and opioid-induced constipation. This compound is also applicable in cancer research, providing insights into gastrointestinal function and potential therapeutic interventions.
Grouped product items
Size Price Stock Qty
5mg
$50.00
In stock
10mg
$75.00
In stock
25mg
$150.00
In stock
50mg
$240.00
In stock
100mg
$360.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLubiprostone (hemiketal) is a selective activator of chloride channel 2 (CLCN2). It effectively increases chloride ion secretion in the intestine, enhancing fluid secretion and promoting intestinal peristalsis, making it valuable for studying chronic idiopathic constipation and opioid-induced constipation. This compound is also applicable in cancer research, providing insights into gastrointestinal function and potential therapeutic interventions.
Product Information
Catalog NumA66533
FormulaC20H32F2O5
Molecular Weight390.46
CAS Number333963-40-9
SMILESCCCCC(F)([C@@]1(O[C@@]2([H])[C@]([C@H](C(C2)=O)CCCCCCC(O)=O)([H])CC1)O)F
SynonymsRU-0211 (hemiketal); SPI-0211 (hemiketal)
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