Lysophosphatidylethanolamines (LPE) are endogenous lysophospholipids generated through the deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). LPE is known to enhance ERK1/2 phosphorylation in PC12 cells, an effect that can be attenuated by MEK inhibitors such as U-0126 and PD 98059, as well as the EGFR inhibitor AG-1478. Additionally, LPE promotes neurite outgrowth and increases neurofilament M expression in these cells. This product encompasses various molecular species of lysophosphatidylethanolamine characterized by differing fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position, making it suitable for diverse biological research applications.
Lysophosphatidylethanolamines (LPE) are endogenous lysophospholipids generated through the deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). LPE is known to enhance ERK1/2 phosphorylation in PC12 cells, an effect that can be attenuated by MEK inhibitors such as U-0126 and PD 98059, as well as the EGFR inhibitor AG-1478. Additionally, LPE promotes neurite outgrowth and increases neurofilament M expression in these cells. This product encompasses various molecular species of lysophosphatidylethanolamine characterized by differing fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position, making it suitable for diverse biological research applications.
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