m-PEG16-azide is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, m-PEG16-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) tagged molecules, making it a valuable tool for bioconjugation and targeted protein degradation studies. Its versatile reactivity enhances the development of novel therapeutic strategies in chemical biology and drug discovery.
m-PEG16-azide is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, m-PEG16-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) tagged molecules, making it a valuable tool for bioconjugation and targeted protein degradation studies. Its versatile reactivity enhances the development of novel therapeutic strategies in chemical biology and drug discovery.
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