m-PEG3-Sulfone-PEG3-azide is a PEG-based linker specifically designed for PROTAC synthesis. Featuring an azide functional group, this compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating the development of innovative targeted protein degradation strategies in chemical biology research.
m-PEG3-Sulfone-PEG3-azide is a PEG-based linker specifically designed for PROTAC synthesis. Featuring an azide functional group, this compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating the development of innovative targeted protein degradation strategies in chemical biology research.
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