Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery.
Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery.
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