MEK-IN-7 is a potent, orally available, and selective inhibitor of MEK1, demonstrating an IC50 of 29.62 nM. This compound effectively inhibits the proliferation of HT29 and A375 cancer cell lines, with IC50 values of 0.62 nM and 0.40 nM, respectively. Additionally, MEK-IN-7 has been shown to suppress tumor growth in HL-29 xenograft mouse models, making it a valuable reagent for research in melanoma and colon cancer.
MEK-IN-7 is a potent, orally available, and selective inhibitor of MEK1, demonstrating an IC50 of 29.62 nM. This compound effectively inhibits the proliferation of HT29 and A375 cancer cell lines, with IC50 values of 0.62 nM and 0.40 nM, respectively. Additionally, MEK-IN-7 has been shown to suppress tumor growth in HL-29 xenograft mouse models, making it a valuable reagent for research in melanoma and colon cancer.
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