Meropenem-vaborbactam is a carbapenem antibiotic combined with a boronic acid-based beta-lactamase inhibitor, designed to effectively combat Enterobacteriaceae, particularly Klebsiella pneumoniae strains producing carbapenemases. This compound demonstrates notable in vitro activity against Pseudomonas aeruginosa, with MIC50 values of 0.5 μg/mL and MIC90 values of 8 μg/mL, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic strategies.
Meropenem-vaborbactam is a carbapenem antibiotic combined with a boronic acid-based beta-lactamase inhibitor, designed to effectively combat Enterobacteriaceae, particularly Klebsiella pneumoniae strains producing carbapenemases. This compound demonstrates notable in vitro activity against Pseudomonas aeruginosa, with MIC50 values of 0.5 μg/mL and MIC90 values of 8 μg/mL, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic strategies.
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