Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent that features an azide group, facilitating bioorthogonal reactions. It contains a methyltetrazine moiety and two carboxylic acid groups, enabling stable covalent bonding with TCO-containing compounds through inverse-electron demand Diels-Alder cycloaddition. This reaction occurs rapidly and with high selectivity, avoiding the need for copper catalysis or elevated temperatures. Additionally, the PEG linker enhances water solubility, while the terminal carboxylic acid can react with primary amines in the presence of coupling agents to form stable amide bonds, making it suitable for various research applications in chemical biology.
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent that features an azide group, facilitating bioorthogonal reactions. It contains a methyltetrazine moiety and two carboxylic acid groups, enabling stable covalent bonding with TCO-containing compounds through inverse-electron demand Diels-Alder cycloaddition. This reaction occurs rapidly and with high selectivity, avoiding the need for copper catalysis or elevated temperatures. Additionally, the PEG linker enhances water solubility, while the terminal carboxylic acid can react with primary amines in the presence of coupling agents to form stable amide bonds, making it suitable for various research applications in chemical biology.
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