Catalog No.
Product Name
Application
Product Information
Citations
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Cy5 Derivative
Sulfo-Cy5-tetrazine is a Cy5 derivative featuring a tetrazine moiety that serves as a potent click chemistry reagent. This compound exhibits fluorescence properties similar to Cy5, with excitation/emission maxima at 633/647 nm. Sulfo-Cy5-tetrazine is optimized for use in biochemical applications requiring selective labeling, enabling the visualization of biomolecules through inverse electron demand Diels-Alder reactions with trans-cyclooctene (TCO) functionalized partners. This reagent is ideal for use in various biological research contexts, including molecular imaging and assay development. -
Red Fluorescent Dye
Janelia Fluor® 646, Tetrazine is a red fluorescent dye characterized by its tetrazine moiety. This compound serves as a versatile click chemistry reagent, enabling efficient labeling through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing molecules. Its robust fluorescent properties make JF646, Tetrazine suitable for applications in cellular imaging, facilitating the visualization of dynamic biological processes in live cells. -
Fluorescence Dye
Sulfo-Cy3-Tetrazine is a water-soluble cyanine fluorescence dye that features a tetrazine group for click chemistry applications. It functions through an inverse electron demand [4+2] cycloaddition reaction with trans-cyclooctene or other strained olefins, facilitating specific labeling and detection of biomolecules. This reagent is ideal for various applications in fluorescence microscopy, imaging, and other biological assays requiring precise and efficient molecular tagging. -
Click Chemistry Reagent
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent characterized by a methyltetrazine functionality. This compound serves as a fluorophore linker for trans-cyclooctene-based labeling applications, facilitating the visual tracking of biomolecules. It exhibits excellent stability at physiological pH and demonstrates high reactivity towards cyclooctene, making it suitable for a variety of biological and biochemical research applications, including target identification and protein labeling. -
Click Chemistry Reagent
Sulfo-Cy3-Methyltetrazine is a click chemistry reagent characterized by its methyltetrazine functionality and a water-soluble fluorescent dye. It exhibits excellent stability under physiological pH conditions, making it suitable for various biological applications. This reagent effectively couples with trans-cyclooctene and shows a high reactivity towards cyclooctene, enabling precise labeling and detection in live-cell imaging and other bioorthogonal applications. -
Click Chemistry Reagent
Cy3 methyltetrazine is a click chemistry reagent that features methyltetrazine building blocks, known for its high reactivity towards cyclooctene. This tetrazine-modified fluorescent probe enables the analysis of protein phosphorylation both in solution and within living cells, making it a valuable tool for various biological research applications. Its unique properties facilitate targeted labeling and visualization in the study of protein dynamics and cellular processes. -
Fluorescent Dye
5-FITC-Tetrazine is a fluorescent dye that integrates fluorescein isothiocyanate (FITC) with tetrazine chemistry, enabling targeted labeling and imaging applications. This reagent offers enhanced fluorescent properties, making it suitable for a variety of biological assays, including live-cell imaging and fluorescence microscopy. Its stability and compatibility with diverse biomolecules make it a valuable tool for researchers in the field of cellular biology and biochemistry. -
Dye
TAMRA-PEG4-methyltetrazine is a fluorescent dye derivative that features a tetrazine moiety for selective labeling applications. The presence of four polyethylene glycol (PEG) units enhances solubility and stability. This compound is designed to undergo inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners, making it suitable for bioconjugation and imaging studies in chemical biology research. -
ADC Linker
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). It features a tetrazine moiety that facilitates rapid and selective conjugation through an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives. This compound enhances the stability and efficacy of ADCs, making it valuable for targeted delivery of therapeutics in cancer research and other applications in bioconjugation. -
Azide Compound
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent that features an azide group, facilitating bioorthogonal reactions. It contains a methyltetrazine moiety and two carboxylic acid groups, enabling stable covalent bonding with TCO-containing compounds through inverse-electron demand Diels-Alder cycloaddition. This reaction occurs rapidly and with high selectivity, avoiding the need for copper catalysis or elevated temperatures. Additionally, the PEG linker enhances water solubility, while the terminal carboxylic acid can react with primary amines in the presence of coupling agents to form stable amide bonds, making it suitable for various research applications in chemical biology. -
ADC Linker
Diazido-methyltetrazine tri-arm is a versatile ADC linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective conjugation of cytotoxic agents to antibodies, enhancing therapeutic efficacy while minimizing off-target effects. Its structural features allow for efficient formation of stable linkages, making it suitable for various applications in ADC development and cancer research. -
ADC Linker
Me-Tetrazine-Me-Ph-amide-Lys(Boc)-Lys-N3 is an innovative ADC linker that facilitates the construction of antibody-drug conjugates (ADCs). This reagent provides a robust mechanism for site-specific conjugation, enhancing the therapeutic efficacy of ADCs. It is particularly useful in research applications focused on targeted cancer therapies and precision medicine. -
Methyltetrazine Compound
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent featuring a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds through an Inverse-Electron-Demand Diels-Alder reaction with TCO-containing substrates, eliminating the need for Cu-catalysis or elevated temperatures. It is primarily utilized in bioconjugation applications, enhancing the specificity and efficiency of labeling procedures in biological research. -
ADC Linker
Tetrazine-biotin is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine moiety that participates in the inverse electron demand Diels-Alder (iEDDA) reaction with TCO-containing molecules, facilitating efficient click chemistry. Tetrazine-biotin is a valuable tool for researchers exploring targeted drug delivery and the development of novel ADC therapies. -
ADC Linker
Azido-methyltetrazine di-arm linker is a novel linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This multivalent linker facilitates the conjugation of therapeutic agents to antibodies, enhancing the efficacy and targeting capabilities of ADCs. It is an essential reagent for researchers exploring the development of targeted cancer therapies and improving the selectivity of drug delivery systems. -
ADC linker
Tetrazine-SS-Biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a Tetrazine moiety, it facilitates the inverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) derivatives. This unique reactivity enables precise targeting and controlled release of therapeutic agents, making it valuable in cancer research and the development of targeted therapies. -
ADC Linker
Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects. -
ADC Linker
Methyltetrazine-DBCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Additionally, the inclusion of a tetrazine moiety allows for inverse electron demand Diels-Alder reactions (iEDDA) with trans-cyclooctene (TCO) compounds. Methyltetrazine-DBCO is an essential reagent for researchers developing targeted therapies through click chemistry methodologies. -
PROTAC Linker
Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions. -
PROTAC Linker
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology. -
PROTAC Linker
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and flexibility, thereby improving the efficacy of targeted protein degradation. It is suitable for various research applications, particularly in the study of targeted therapies and cellular protein regulation. -
PROTAC Linker
Tetrazine-Ph-NHS ester is a key PROTAC linker utilized in the synthesis of protein-targeting chimeras. This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO)-modified entities. Its application is vital for the development of targeted protein degradation strategies in chemical biology research, enabling the selective modulation of protein levels within cells. -
PROTAC Linker
Methyltetrazine-Ph-NHS ester is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a tetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) moieties. Its key biological activity lies in enabling targeted protein degradation, providing a valuable tool for researchers exploring protein function and dynamics in cellular systems. Methyltetrazine-Ph-NHS ester is suitable for applications in chemical biology and drug discovery research. -
PROTAC Linker
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances target specificity and cellular degradation efficiency by linking E3 ligases to target proteins. Its application in PROTAC development enables the study of targeted protein degradation mechanisms, providing valuable insights in drug discovery and therapeutic interventions. -
PROTAC Linker
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies. -
PROTAC Linker
Methyltetrazine-acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the efficient conjugation of ligands to E3 ligases, enhancing the targeted degradation of specific proteins. This compound is essential for researchers focusing on protein modulation and degradation in various cellular contexts. -
PROTAC Linker
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) substrates. It is particularly useful in creating tailored PROTACs for targeted protein degradation studies, facilitating the development of new therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
Tetrazine-Ph-acid is a specialized linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating selective and efficient protein degradation. Its application in the development of PROTACs enables researchers to explore targeted protein modulation and therapeutic interventions in various biological systems. -
PROTAC Linker
Methyltetrazine-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is suitable for applications in drug discovery and development, enabling researchers to investigate protein function and therapeutic potential in various biological contexts. -
PROTAC Linkers
Methyltetrazine-PEG8-NHS ester is a PEG-based linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound effectively connects a target protein and an E3 ligase for targeted degradation, enhancing the specific elimination of proteins in cellular systems. Its utility in PROTAC synthesis makes it an essential reagent for researchers exploring novel therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
Methyltetrazine-amido-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases. Its application in PROTAC development enables enhanced therapeutic strategies in the field of targeted protein degradation for various diseases, including cancer. -
PROTAC Linkers
Methyltetrazine-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting targeted protein degradation. Its ability to enhance solubility and bioavailability makes it a valuable tool in chemical biology and drug discovery applications focused on protein modulation. -
PROTAC Linker
Methyltetrazine-Sulfo-NHS ester sodium is a recognized PROTAC linker designed for the synthesis of degradation-targeting chimeras. This compound facilitates the conjugation of ligands to proteins of interest, enabling targeted protein degradation studies. Its application spans various areas of research, including drug development and molecular biology, where precise modulation of protein activity is required. -
PROTAC Linkers
Methyltetrazine-PEG8-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the formation of targeted protein degradation complexes by linking the E3 ligase to the protein of interest. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Methyltetrazine-propylamine is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This linker features an alkyl chain structure, enhancing the stability and functionality of the resulting conjugates. It is ideal for researchers focusing on targeted protein degradation and the development of innovative therapeutic modalities for various diseases. -
PROTAC Linkers
Methyltetrazine-PEG24-amine is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. This compound is critical for researchers developing novel therapeutic strategies that leverage the ubiquitin-proteasome system to selectively eliminate unwanted proteins. Its biocompatibility and versatility make it a valuable tool in drug discovery and development. -
PROTAC Linkers
Methyltetrazine-PEG5-triethoxysilane is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. It serves as a crucial component in the development of novel therapeutic strategies aimed at modulating protein expression and activity in various biological systems. -
PROTAC Linker
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring a tetrazine moiety, this compound facilitates selective interactions through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing partners. Its unique chemical structure allows for efficient conjugation and modularity in the design of targeted protein degradation experiments, making it a valuable tool in chemical biology and therapeutic development research. -
PROTAC Linker
Methyltetrazine-Ph-PEG4-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, functioning as a vital component in targeted protein degradation strategies. This compound features a Tetrazine moiety that enables inverse electron-demand Diels-Alder reactions (iEDDA) with TCO-containing partners, enhancing the efficiency of linkage in complex biomolecular assemblies. Additionally, the azide functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This dual reactivity expands its utility in bioconjugation and chemical biology applications. -
PROTAC Linkers
Methyltetrazine-PEG4-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound incorporates a methyltetrazine moiety, facilitating targeted protein degradation through the recruitment of E3 ligases. Its biologically active structure makes it valuable for research applications in cellular signaling, protein regulation, and the development of innovative therapeutic strategies. -
PROTAC linker
Methyltetrazine-amido-PEG7-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is suitable for strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool in chemical biology and drug development. -
Click Chemistry Reagent
Tetrazine-Amine monohydrochloride is a click chemistry reagent featuring a tetrazine group, which facilitates covalent labeling of living cells via inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing molecules. This compound enables precise bioconjugation in various biological studies, making it an essential tool for researchers focusing on protein labeling, drug delivery, and imaging applications. Its ability to promote rapid and selective reactions enhances its utility in the design of targeted therapeutics and biomolecular probes. -
Tetrazines
Methyltetrazine-amine is a tetrazine compound that enables site-specific dual functionalization of bioconjugates. This reagent facilitates the precise modification of biomolecules, making it valuable in the development of targeted therapeutics and imaging agents. Its unique reactivity allows for selective labeling and conjugation, supporting various applications in chemical biology and drug development. -
Tetrazines Compound
Methyltetrazine-amine hydrochloride is a tetrazine compound that serves as a versatile reactive moiety for site-specific dual functionalization of bioconjugates. This reagent facilitates efficient labeling and immobilization strategies in chemical biology applications. It can be effectively utilized during protein precipitation in experiments employing trans-cyclooctene, making it a valuable tool for researchers focusing on conjugation methodologies and biomolecular studies. -
PEG Derivative
Methyltetrazine-PEG4-amine hydrochloride is a PEG derivative characterized by the presence of a free amine and a methyltetrazine moiety. This compound serves as a versatile click chemistry reagent, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO)-containing molecules. Methyltetrazine-PEG4-amine hydrochloride is valuable in biological research for applications such as bioconjugation, drug delivery, and imaging studies, facilitating the development of targeted therapies and diagnostic tools. -
PEG Derivative
Methyltetrazine-PEG4-amine is a PEG derivative featuring a free amine and a methyltetrazine moiety. As a versatile click chemistry reagent, it facilitates the inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) containing compounds. This reagent can be employed in bioconjugation strategies, enabling the development of targeted therapeutics and imaging agents in chemical biology research. -
Biochemical Assay Reagent
Methyltetrazine-PEG5-sulfo-NHS ester sodium is a versatile biochemical assay reagent that functions primarily as a crosslinker for biomolecules. This compound enables efficient conjugation with amine-containing molecules, facilitating the study of protein interactions and modifications. Its solubility in aqueous environments increases its applicability in various biological assays and research applications, making it a valuable tool in chemical biology and bioconjugation techniques. -
Biochemical Assay Reagent
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane is a versatile click chemistry reagent designed for biochemical assays, featuring three carboxylic acid groups and a methyltetrazine moiety. It facilitates the formation of stable covalent bonds with TCO-containing compounds through a highly selective inverse-electron demand Diels-Alder cycloaddition reaction, eliminating the need for catalysis or elevated temperatures. Additionally, the terminal carboxylic acid can efficiently couple with primary amines in the presence of activators such as EDC or HATU, forming stable amide bonds for a variety of bioconjugation applications in chemical and biological research. -
Biochemical Assay Reagent
Methyltetrazine-PEG4-DBCO is a versatile biochemical assay reagent featuring a PEG linker, a terminal TCO reactive moiety, and a DBCO group. The DBCO component facilitates copper-free Click Chemistry reactions, enabling efficient bioconjugation. This reagent is ideal for converting azido-containing peptides or proteins into tetrazine-modified counterparts without the need for catalysts or auxiliary reagents, making it a valuable tool for researchers in biochemistry and protein engineering. -
Biochemical Assay Reagent
Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a versatile click chemistry PEG reagent featuring three carboxylic acid groups and a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds with TCO-containing compounds through a rapid inverse-electron demand Diels-Alder cycloaddition, notable for its exceptional selectivity and lack of reliance on copper catalysts or elevated temperatures. Additionally, the terminal carboxylic acid can react with primary amine groups using coupling agents such as EDC or HATU to generate stable amide bonds, making it suitable for various biochemical assay applications.
