Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial Agent
RWJ-416457 is an orally bioavailable antibacterial agent that targets 23S rRNA within the ribosome. This compound exhibits potent activity against Gram-positive bacterial infections, making it a valuable tool for researchers studying antibiotic mechanisms and bacterial resistance. Its specific action on ribosomal components positions RWJ-416457 as an important candidate for further exploration in antimicrobial research. -
Bacterial
FCE 22250 is a 3-azinomethylrifamycin that targets bacterial infections, demonstrating long-term in vivo persistence and effective oral absorption. It exhibits potent antimicrobial activity across a broad spectrum, particularly against mycobacteria, making it a valuable reagent for research applications focused on bacterial resistance and treatment strategies. -
Antibacterial Drug
Curcapicycloside (Pilosidine) is a norlignan glucoside that exhibits antibacterial activity primarily targeting Escherichia coli. This compound has potential applications in antibacterial drug development and pharmacological studies aimed at understanding its mechanisms of action against bacterial infections. It serves as a valuable tool for researchers investigating novel antibacterial agents. -
Antibacterial Agent
Mucrolidin is an eudesmane-type sesquiterpenoid with antibacterial activity. Isolated from the aerial parts of Homalomena occulta, Mucrolidin demonstrates modest efficacy against bacterial strains. This compound can be used in research applications focusing on the development of new antibacterial agents and the study of natural product pharmacology. -
Bacterial Inhibitor
Acaterin is a bacterial inhibitor derived from Pseudomonas, known for its role in antimicrobial activity. Research indicates that its biosynthesis is regulated through a complex gene cluster, with studies highlighting its associated biosynthetic pathway. Comparative transcriptomics further demonstrates the compound's formation is intricately linked to bacterial regulatory networks, making it valuable for studies in bacterial physiology and the development of new antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 102 is a potent antibacterial compound that exhibits significant in vitro and in vivo activity against Staphylococcus aureus, with minimum inhibitory concentrations (MICs) below 0.5 μg/mL. Additionally, it moderately inhibits the cytochrome P450 enzyme CYP3A4, with an IC50 value of 6.148 μM. This compound has demonstrated efficacy in reducing Methicillin-resistant Staphylococcus aureus (MRSA) loads in infected mice models, making it valuable for research into antibiotic resistance and therapeutic interventions. -
Antibacterial Agent
Antibacterial Agent 201 is an antibacterial compound that disrupts membrane integrity in target organisms. It demonstrates significant efficacy against Staphylococcus aureus strain RN4220, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa strain PA01, and Escherichia coli strain ANS1, with minimum inhibitory concentrations (MIC99) of 2.0, 1, 8.1, and 2.2 μg/mL, respectively. This reagent is suitable for research applications focused on studying bacterial resistance mechanisms and evaluating antibacterial properties. -
Antibacterial Agent
Antibacterial Agent 48 is a potent antibacterial compound that enhances the efficacy of the beta-lactam antibiotic Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC). This synergy suggests its potential utility in combating antibiotic-resistant bacterial strains and improving treatment outcomes. It is a valuable reagent for research focused on developing novel antibacterial therapies and exploring resistance mechanisms. -
Antimycobacterial Agent
Antimycobacterial agent-1 selectively targets Mycobacterium tuberculosis (M. tuberculosis) H37Ra and exhibits potent antimycobacterial activity with a minimum inhibitory concentration (MIC) of 1 μg/ml. This compound demonstrates relatively low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells. Its efficacy and safety profile make it a valuable tool for research focused on tuberculosis and antimycobacterial drug development. -
Antibacterial Agent
Antibacterial Agent 94 is a potent antibacterial compound that demonstrates significant activity against MRSA persisters. This agent disrupts bacterial membrane integrity and interferes with the synthesis of phosphatidylglycerol (PG). Its mechanism of action makes it a valuable tool in the research of antibacterial therapies and the exploration of drug resistance in pathogenic bacteria. -
Bacterial
Berninamycin A is a cyclic thiopeptide antibiotic that targets Gram-positive bacteria by inhibiting protein biosynthesis through specific binding to ribosomal subunits. Initially isolated from Streptomyces bernensis, this compound also induces the transcriptional activator TipA in Streptomyces, highlighting its role in antimicrobial research. Berninamycin A is valuable for studies involving antibiotic resistance mechanisms and the development of new antibacterial agents. -
Antibacterial Agent
Asperglaucin B is an alkylated salicylaldehyde derivative derived from the fungus Aspergillus chevalieri SQ-8, recognized for its antibacterial properties. This compound exhibits potent antibacterial activity against plant pathogens, specifically Pseudomonas syringae pv actinidae and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. Asperglaucin B serves as a valuable tool in research focused on plant disease control and the development of novel antibacterial agents. -
Bacterial Inhibitor
8-Epidiosbulbin E acetate is a furanoid compound derived from Dioscorea bulbifera L. It functions as a bacterial inhibitor, demonstrating broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. Additionally, it has been noted to induce liver injury in murine models, highlighting its potential impact on liver function. This compound is valuable for research involving antibiotic resistance and bacterial pathogenicity. -
Bacterial Inhibitor
FtsZ-IN-10 is a bacterial division inhibitor that targets the assembly of FtsZ, a critical protein involved in bacterial cytokinesis. By binding specifically to Bacillus subtilis FtsZ monomers, FtsZ-IN-10 disrupts their polymerization, ultimately hindering the formation of the Z ring and inhibiting cell division. This compound has demonstrated efficacy against antibiotic-resistant clinical isolates, including Staphylococcus aureus and Enterococci, making it a valuable tool in microbiological research and antibiotic development. Additionally, FtsZ-IN-10 may stimulate nucleotide-free archaeal FtsZ to form structured polymers, contributing to its versatile applications in studying bacterial growth and division mechanisms. -
Antibacterial Agent
Mycolic acid IIa is a key structural lipid of the mycobacterial cell wall, primarily sourced from Mycobacterium bovis BCG. This compound plays a crucial role in modulating membrane permeability and stability, making it a valuable tool for research on Mycobacterium tuberculosis infections. Its antibacterial properties support studies aimed at understanding mycobacterial pathogenesis and developing new therapeutic approaches. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Antibacterial Agent
Olamufloxacin is an orally active fluoroquinolone antibacterial agent that exerts its effect by targeting bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and effectively inhibits the growth of extracellular Legionella species as well as intracellular Legionella pneumophila. Olamufloxacin also mitigates cytotoxicity associated with Legionella pneumophila and has been shown to increase survival rates and decrease lung bacterial burden in infected guinea pig models. This reagent is valuable for research focused on legionnaires’ disease and its underlying pathogenic mechanisms. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Antibacterial Agent
Syringopicroside is a natural compound derived from Syringa oblata Lindl. It exhibits significant antibacterial activity, making it a valuable tool for research into microbial infections and potential therapeutic applications. This compound is of interest for studies exploring the mechanisms of action against a variety of bacterial strains. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Antibacterial Agent
8,9-Dehydro-7,9-diisobutyryloxythymol is a derivative of thymol that exhibits antibacterial properties. This compound demonstrates selective inhibitory activity against Gram-positive bacteria, notably Bacillus cereus, while showing no detectable cytotoxicity against human cancer cell lines in vitro. 8,9-Dehydro-7,9-diisobutyryloxythymol is valuable for research applications focused on bacterial infections and developing antibacterial agents. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Antibacterial Peptide
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment derived from the cell surface adhesin of Streptococcus pyogenes, functioning as an antibacterial peptide. This compound specifically inhibits the interaction between adhesin and salivary receptors, thereby preventing the recolonization of Streptococcus pyogenes. Its potential applications include studies in microbial pathogenesis and the development of novel antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 96 (compound 4k) is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating significant antitubercular activity against both drug-susceptible and multidrug-resistant strains. This agent is valuable for research applications focused on tuberculosis treatment, particularly in the face of emerging resistance. However, it is important to note that Antibacterial Agent 96 exhibits toxicity to HepG2 and Vero cell lines. -
Antibacterial Agent
3,4-Seco-mansumbinoic acid is an antibacterial agent isolated from the oleo-resin of *Commiphora molmol*. This compound demonstrates significant in vitro anti-staphylococcal activity, particularly against the multidrug-resistant strain *Staphylococcus aureus* SA-1199B, with a minimum inhibitory concentration (MIC) of 4 μg/mL. Additionally, 3,4-Seco-mansumbinoic acid shows weak potentiation of Ciprofloxacin and Tetracycline against *Salmonella enterica* serovar Typhimurium strains. This compound is valuable for research focused on multidrug-resistant bacterial infections. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Antibacterial Agent
LAB 149202F is an acylanilide antibacterial agent that exerts inhibitory effects on bacterial strains exhibiting formyl and phosphate resistance. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms and the development of new therapeutic strategies. Its application in various biological assays supports the exploration of bacterial pathogenesis and antibiotic efficacy. -
Antibacterial Agent
Desethylene Ciprofloxacin hydrochloride functions as an antibacterial agent, derived from the metabolism of Ciprofloxacin. It acts primarily as a topoisomerase IV inhibitor, contributing to its antibacterial properties. This compound is suitable for research applications focused on antibacterial mechanisms and the study of bacterial resistance. -
Antibacterial Agent
Antibacterial Agent 130 is a 1,1-diarylthiogalactoside that specifically targets the lectin LecA from Pseudomonas aeruginosa. It exhibits a high affinity for LecA, with a Kd of 1 μM, demonstrating effective antibiofilm activity. Although it does not possess bactericidal properties, it is valuable for research into bacterial adhesion and biofilm formation, making it a useful tool in studies of Pseudomonas aeruginosa virulence and infection mechanisms. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Antibacterial Agent
Ticarcillin is a semisynthetic carboxypenicillin with extended-spectrum antibacterial activity, primarily targeting bacterial cell wall synthesis. It is effective against a range of gram-positive cocci, such as streptococci and staphylococci, as well as most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin is relevant for research applications involving lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections. -
Antibacterial Agent
Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor, exhibiting an IC50 of 0.04 µM. It effectively suppresses the inflammatory response induced by Staphylococcus aureus by inhibiting the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and proteins associated with the NLRP3 inflammasome. This compound is useful for research applications focused on bacterial infections and inflammatory processes. -
Antibacterial/Antimalarial
1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid that exhibits antibacterial and antimalarial properties. This compound is derived from an Indonesian sponge and has potential applications in the study of infectious and tropical parasitic diseases. Its unique structural features may offer insights into the development of new therapeutic strategies against challenging pathogens. -
Antibacterial Agents
Cefetamet pivoxyl is a cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits potent antibacterial activity against a range of enteropathogens, specifically Gram-negative bacteria, with the exception of Pseudomonas aeruginosa, as well as Legionella pneumophila. This compound is primarily utilized in research related to antibacterial efficacy and the development of new antimicrobial therapies. -
Antibacterial Agent
Carumonam is a sulfonated monocyclic β-lactam antibiotic that specifically targets penicillin-binding proteins (PBPs). It demonstrates potent antibacterial activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while exhibiting limited to no inhibitory effect on Streptococcus pneumoniae and Staphylococcus aureus. Additionally, Carumonam is resistant to beta-lactamase-mediated hydrolysis, making it a valuable compound for research on antibiotic resistance and infection control studies. -
Antibacterial Agent
Pseudomonic acid C is an antibacterial agent that targets bacterial cell wall synthesis through inhibition of isoleucyl-tRNA synthetase. This compound exhibits potent antibacterial activity against various Gram-positive bacteria, making it a valuable tool for research in microbiology and antibiotic development. Its mechanism offers insights into bacterial resistance and the potential for novel therapeutic strategies. -
Antibacterial Agent
Pipemidic acid trihydrate is an antibacterial agent that targets DNA gyrase to exert its effects. This compound demonstrates activity against a range of gram-negative bacteria, including Pseudomonas aeruginosa, as well as certain gram-positive bacteria. It is suitable for research focused on intestinal, urinary, and biliary tract infections, providing a valuable tool for studying bacterial resistance and therapeutic interventions. -
Antibacterial Agent
Antibacterial Agent 104 is a potent antibacterial compound primarily targeting bacterial pathogens. Demonstrating excellent in vitro antibacterial activity, it also exhibits significant efficacy in vivo against methicillin-resistant Staphylococcus aureus (MRSA). This compound is valuable for research focused on developing treatments for bacterial infections and studying antibiotic resistance mechanisms. -
Bacterial Inhibitor
MT0703 is an aminothiazolyl glycyl cephalosporin that targets bacterial pathogens, exhibiting potent anti-Pseudomonas activity. This compound is studied for its potential in understanding bacterial resistance mechanisms and developing novel therapeutic strategies. Its structure, featuring a 1,5-dihydroxy-4-pyridone-2-carbonyl group, enhances its efficacy against a range of bacterial infections. -
Antibacterial
GT-1 is a siderophore-linked cephalosporin with notable antibacterial activity. It demonstrates efficacy against clinically significant isolates, including Pseudomonas aeruginosa, Klebsiella oxytoca, Proteus species, Serratia marcescens, and Enterobacter aerogenes. This compound is valuable for research applications focusing on antibiotic resistance and the development of novel antibacterial therapies. -
Antibacterial Agent
Cefroxadine is an orally active cephalosporin antibiotic that targets bacterial cell wall synthesis. It demonstrates superior antibacterial activity compared to cephalexin against Escherichia coli and Klebsiella pneumoniae, with minimum inhibitory concentration (MIC) values of 3.13 and 1.56 μg/mL, respectively. This compound is suitable for research applications focusing on bacterial infections and antibiotic resistance mechanisms. -
Antibacterial peptide
LL-37 GKE is an antibacterial peptide derived from the active domain of LL-37. It exhibits significant antibacterial activity, making it a valuable candidate for research in antibiotic development. LL-37 GKE’s properties offer potential applications in the study of infection control and the enhancement of antimicrobial therapies. -
Anti-tumor/bacterial Agent
Napyradiomycin A1 is an enantioselective compound belonging to the napyradiomycin family, characterized by its halogenated structure. This compound exhibits significant anti-tumor and antibacterial activities, making it a valuable tool in cancer research and microbiology. Its efficacy against various tumor cell lines, along with activity against select bacterial strains, positions Napyradiomycin A1 as a promising candidate for further investigation in therapeutic applications. -
ATPase/Bacterial Inhibitor
Dihydronovobiocin is a bacterial inhibitor that targets ATPase activity by binding to the GyrB subunit of DNA gyrase. This compound is useful for investigating the interactions between coumarin antibiotics, such as Novobiocin, Chlorobiocin, and Coumermycin, and their effects on DNA gyrase function. Dihydronovobiocin also has potential applications in the study of bacterial infections, facilitating research into the mechanisms of antibiotic action and resistance. -
Antibacterial Agent
Sulfaethoxypyridazine is a sulfonamide antibacterial agent that primarily targets bacterial dihydropteroate synthase, inhibiting folate synthesis. This compound exhibits significant antibacterial activity, making it effective for use in veterinary medicine as an additive in feedstuffs. Its application is centered on the prevention and treatment of bacterial infections in livestock, enhancing animal health and productivity. -
Antimalarial/Antibacterial Agent
K-41 is an orally active antibiotic derived from Streptomyces hygroscopicus. This compound exhibits significant antibacterial and antiplasmodial activities, making it a valuable tool in research focused on infectious diseases. K-41 can be utilized in studies investigating potential treatments for malaria and bacterial infections, contributing to the development of new therapeutic strategies. -
Bacterial Inhibitor
(4-Aminobenzyl)phosphonic acid is a bioactive compound that acts as a bacterial inhibitor. It exhibits notable antibacterial and potential anticancer activities, making it useful in various research applications, particularly in the synthesis of new compounds aimed at inhibiting bacterial growth. Its unique structural properties enable effective interaction with biological targets, facilitating the exploration of novel therapeutic strategies.
