MRL-494 is an antibacterial agent that targets the β-barrel assembly machine A (BamA), effectively overcoming efflux mechanisms and the outer membrane permeability barrier. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC) of 12.5 μM against Staphylococcus aureus (COL) and 25 μM against Escherichia coli (JCM158). This compound is valuable for research into novel antibacterial therapies and mechanisms of resistance in both Gram-positive and Gram-negative bacteria.
MRL-494 is an antibacterial agent that targets the β-barrel assembly machine A (BamA), effectively overcoming efflux mechanisms and the outer membrane permeability barrier. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC) of 12.5 μM against Staphylococcus aureus (COL) and 25 μM against Escherichia coli (JCM158). This compound is valuable for research into novel antibacterial therapies and mechanisms of resistance in both Gram-positive and Gram-negative bacteria.
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