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Catalog No.
Product Name
Application
Product Information
Citations
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Influenza Virus Inhibitor
Influenza virus-IN-3 is a selective inhibitor targeting the influenza virus, demonstrating potent antiviral activity with IC50 values of 0.88, 0.10, 5.5, and 0.51 µM against H5N1, H5N2, H5N6, and H5N8 strains, respectively. This compound effectively inhibits neuraminidase (NA) enzyme activity, making it a valuable tool in influenza research. With a CC50 greater than 200 µM, Influenza virus-IN-3 displays low cytotoxicity, supporting its potential use in therapeutic applications. -
CEN Inhibitor
Cap-dependent endonuclease-IN-23 is a selective inhibitor of cap-dependent endonuclease (CEN), effectively blocking its activity. This compound demonstrates significant antiviral properties by inhibiting the replication of influenza A virus. Cap-dependent endonuclease-IN-23 is intended for research applications focused on understanding and combating influenza virus infections. -
Influenza Virus Inhibitor
Viral polymerase-IN-1 hydrochloride is a potent inhibitor of influenza A and B viruses, demonstrating inhibitory concentration (IC90) values ranging between 11.4 and 15.9 μM. This compound also exhibits activity against SARS-CoV-2, effectively suppressing viral infection. The primary mechanism of action involves the disruption of viral RNA replication and transcription within host cells, making it a valuable reagent for research into antiviral therapies and viral pathogenesis. -
PAN Inhibitor
Influenza virus-IN-6 is a potent inhibitor of the N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease, exhibiting an IC50 value of 0.20 μM. This compound demonstrates significant antiviral activity against influenza viruses, making it a valuable tool for research applications focused on influenza virus replication and therapeutics. Its inhibitory effects on PAN endonuclease provide insights into the molecular mechanisms of influenza pathogenesis and potential treatment strategies. -
Neuraminidase Inhibitor
Drechslerine A is a neuraminidase inhibitor with an IC50 value of 0.79 μM. This terpene, isolated from the endophytic fungus Cochliobolus, exhibits significant antiviral activity. Drechsilerine A is utilized in research related to the influenza virus, making it a valuable tool for studying viral pathogenesis and therapeutic interventions. -
Anti-Influenza Agent/PDF Inhibitor
FR198248 is an anti-influenza agent that acts as a peptide deformylase (PDF) inhibitor. Isolated from Aspergillus flavipes, FR198248 demonstrates potent inhibition of the PDF enzyme in Staphylococcus aureus, with an IC50 value of 3.6 µM. This compound is suitable for use in antiviral and antibacterial research applications, allowing for further exploration of its therapeutic potential against viral and bacterial pathogens. -
Neuraminidase Inhibitor
Neuraminidase-IN-3 is a potent inhibitor of influenza neuraminidase, exhibiting IC50 values of 0.73 nM, 0.26 nM, and 0.63 nM against H1N1, H5N1, and H5N8 neuraminidases, respectively. This compound is critical for research focused on antiviral drug development and studying the mechanisms of influenza virus infection and resistance. Its high potency makes it a valuable tool for elucidating neuraminidase functions in viral pathogenesis and therapeutics. -
Influenza Virus Inhibitor
D715-2441 is an influenza virus RNA polymerase inhibitor with an IC50 range of 1.7-4.4 μM. This compound demonstrates broad-spectrum antiviral activity against various influenza A strains. D715-2441 serves as a valuable tool for research pertaining to seasonal influenza and the study of influenza virus dynamics. -
Influenza A Virus Inhibitor
M2WJ332 is a potent inhibitor of the M2 proton channel in the Influenza A virus, specifically targeting the M2S31N mutant variant. With an IC50 of 16 μM, M2WJ332 effectively prevents plaque formation in Influenza A virus carrying the M2S31N mutation. This compound is suitable for research applications focused on understanding and combating Influenza A virus infections. -
Influenza Viru Inhibitor
Laninamivir TFA is a long-acting neuraminidase inhibitor that effectively targets influenza A and B viruses. This antiviral compound exhibits both inhibitory and prophylactic activity, making it a valuable tool for influenza research. Administered via nasal inhalation, Laninamivir TFA demonstrates promising safety and efficacy profiles in the inhibition of viral replication, supporting its application in studies of influenza virus dynamics and treatment strategies. -
Influenza A Inhibitor
Influenza A virus-IN-17 is a selective inhibitor targeting Influenza A viruses, demonstrating effective inhibition with EC90 values of 3.5 μM for H3N2 and 2.6 μM for H1N1. This compound effectively disrupts the cap-snatching polymerase activity, as indicated by an EC90 of 2.1 μM against U2-PB2 chimeric mRNA. Influenza A virus-IN-17 is suitable for research in antiviral drug development and understanding Influenza A virus mechanisms. -
H1N1 Hemagglutinin Inhibitor
RO5464466 is a potent inhibitor of hemagglutinin (HA) in H1N1 influenza viruses. It effectively inhibits HA-mediated hemolysis of chicken erythrocytes, demonstrating an IC50 value of 0.29 μM. This compound is valuable for research applications focused on influenza virus entry mechanisms and the development of antiviral strategies. -
PIV-3 Inhibitor
Caesalmin E is a natural cassane furanoditerpene that acts as a potent inhibitor of the Parainfluenza virus type 3 (PIV-3). Its antiviral properties make it a valuable compound for research focused on combating viral infections, specifically in studies targeting PIV-3-related pathologies. This compound may be utilized in investigations of viral replication mechanisms and as a potential therapeutic agent against respiratory infections. -
Influenza Virus Fusion Inhibitor
BMS-199945 is an influenza virus fusion inhibitor that targets the viral fusion process. It demonstrates significant inhibitory activity with IC50 values of 0.57 μM against influenza A/WSN/33 virus-induced hemolysis in chicken red blood cells and approximately 1 μM in the trypsin protection assay. This reagent is applicable for research into antiviral therapies and the mechanisms of influenza virus pathogenesis. -
NA Inhibitor
ent-Oseltamivir, the enantiomer of Oseltamivir, serves as a neuraminidase (NA) inhibitor targeting influenza virus. Its primary biological activity involves inhibiting viral replication, making it a valuable tool for studying influenza virus infections. Research applications include evaluating antiviral efficacy and resistance mechanisms, contributing to the development of effective therapeutic strategies against influenza. -
Matriptase Inhibitor Intermediate
Sodium 3-iodobenzenesulfonate serves as an intermediate in the synthesis of Matriptase inhibitors, specifically those derived from 3-amidinophenylalanine. This reagent is valuable for research applications involving the inhibition of Matriptase and has been implicated in studies related to the H9N2 influenza virus. Its utility in chemical research makes it an important compound for exploring therapeutic avenues targeting Matriptase and associated viral infections. -
Furin Inhibitor
Furin-IN-3 is a potent and selective inhibitor of the proprotein convertase furin, exhibiting a Ki of 12.4 nM. Additionally, it demonstrates a Ki of 278 nM for PC7. This compound has been shown to exert significant antiviral activity against the furin-dependent H7N7 influenza A virus strain SC35M by inhibiting the cleavage and activation of the viral hemagglutinin (HA), thereby preventing viral membrane fusion with host cells and inhibiting viral replication. Furin-IN-3 is a valuable tool for research into viral infections, particularly those related to influenza. -
Influenza Inhibitor
6-Epi-albassitriol is a potent influenza inhibitor derived from Aspergillus sp. FH-A 6357. It effectively disrupts cholesterol synthesis, achieving an inhibition rate of 40% at a concentration of 10 nM in HepG2 cells. Additionally, 6-Epi-albassitriol demonstrates significant antiviral activity against both influenza A virus and parainfluenza virus, with a minimum inhibitory concentration (MIC) ranging from 44.4 to 133.3 µg/mL, making it a valuable compound for research in antiviral therapeutics. -
IAV Inhibitor
IAV replication-IN-1 is a potent inhibitor of influenza A virus (IAV) replication. This compound effectively reduces the upregulation of inflammatory factors and apoptosis associated with IAV infection, providing potential protective effects against lung injury induced by the virus. It is suitable for research applications focused on viral pathogenesis, inflammation, and therapeutic interventions in respiratory diseases. -
Influenza A Inhibitor
Pimodivir hydrochloride hemihydrate (VX-787) is an orally bioavailable inhibitor targeting the influenza A virus polymerase by specifically interfering with the PB2 subunit. This compound demonstrates significant antiviral activity against various strains of the influenza A virus, making it a valuable tool for research in virology and antiviral drug development. Its mechanism of action paves the way for studying the dynamics of viral replication and the efficacy of potential therapeutic interventions. -
Influenza Virus Inhibitor
M090 is a potent inhibitor of hemagglutinin, specifically targeting the influenza A virus. It effectively inhibits multiple strains of influenza, demonstrating an EC50 in the micromolar range. This compound is essential for research applications involving antiviral drug development and the study of influenza virus pathogenesis. -
Hemagglutinin Inhibitor
F0045(S) is an effective inhibitor of influenza hemagglutinin, demonstrating a KD value of 6.1 µM. This compound is utilized in biological research to investigate its protective effects against influenza virus infections in human cells, making it a valuable tool for antiviral studies and the development of therapeutic strategies. -
Influenza Virus Inhibitor
CEF6 is a 9-amino acid peptide derived from residues 418-426 of the nucleocapsid protein of influenza A virus (H1N1). It functions as an inhibitor of influenza virus, demonstrating key antiviral activity through interference with the viral life cycle. This peptide is valuable for research applications focused on studying viral replication mechanisms and the development of antiviral therapeutics targeting influenza infections. -
Influenza Virus Inhibitor
Sodium copper chlorophyllin B is a sodium-copper complex of chlorophyll with demonstrated antiviral activity against the Influenza virus, exhibiting IC50 values between 50 to 100 μM. It also shows potential activity against HIV. This compound is primarily utilized in research applications aimed at understanding antiviral mechanisms and developing therapeutic strategies for viral infections. -
Influenza Viru Inhibitor
(E/Z)-RA-0002034 is an inhibitor targeting the protease activity of the Chikungunya virus (CHIKV) nsP2, with an IC50 value of 58 nM. This compound covalently modifies the catalytic cysteine residue in a site-specific manner, leading to the inhibition of viral replication. It serves as a valuable tool for studying CHIKV biology and developing antiviral therapies against Chikungunya virus infections. -
Influenza Virus Inhibitor
Glabranine is a flavonoid compound recognized for its inhibitory effects against the influenza virus. Isolated from Tephrosia species, it demonstrates significant interaction with the soluble ectodomain of the dengue virus type 2 (DENV2) E protein, suggesting potential applications in antiviral research. This compound serves as a valuable tool for investigating the mechanisms of viral inhibition and offers insights into therapeutic strategies against influenza and related viral infections. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
IMPDH Inhibitor
Mycophenolic acid-13C17 is a stable isotope-labeled form of Mycophenolic acid, acting as a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) with an EC50 of 0.24 μM. This compound exhibits significant antiviral activity against a variety of RNA viruses, including influenza, and serves as an immunosuppressive agent. Additionally, Mycophenolic acid-13C17 demonstrates antiangiogenic and antitumor properties, making it valuable for research in immunology, virology, and cancer biology. -
Influenza Virus Inhibitor
Oseltamivir is an orally active neuraminidase inhibitor targeting the influenza virus. It demonstrably inhibits various strains of influenza, including A/H3N2, A/H1N2, A/H1N1, and B, with mean IC50 values of 0.67 nM, 0.9 nM, 1.34 nM, and 13 nM, respectively. This compound is essential for studying antiviral strategies and evaluating the efficacy of flu treatments in laboratory settings.
