Catalog No.
Product Name
Application
Product Information
Citations
- Carbendazim is a broad-spectrum benzimidazole fungicide which can be used to control a broad range of diseases on arable crops, fruits, vegetables, ornamentals and medicinal herbs.
- Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei.
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CRK12 inhibitor
GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay. -
PKA activator
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. - Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.
- N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.
- Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria.
- Quinfamide is an antiamebic agent. Quinfamide can be used to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.
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virion mRNA(guanine-7-)-methyltransferase inhibitor
Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. -
asparaginyl endopeptidases inhibitors
RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively. -
Protein synthesis inhibitor
Blasticidin S is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. - Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
- Albendazole sulfoxide D3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.
- N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent.
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Cruzain inhibitor
Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM. - Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has also been used against Vibrio cholerae.
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Parasite Inhibitor
Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies. -
Anti-parasite Agent
D-Arabinose functions as an anti-parasitic agent with a notable capability to inhibit the growth of Caenorhabditis elegans, exhibiting an IC50 of 7.5 mM. This compound effectively penetrates the blood-brain barrier and selectively interferes with the metabolism of D-ribose and D-fructose. Additionally, D-Arabinose demonstrates antibacterial properties by inhibiting biofilm synthesis and activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, contributing to its antidepressant-like effects. D-Arabinose serves as the ring-opened form of the aldopentose D-arabinose. -
Parasite Inhibitor
CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways. -
Antileishmanial Agent
Antileishmanial agent-36 is an indole-dihydropyrimidinone derivative that targets Leishmania species, demonstrating significant anti-leishmanial activity. This compound induces mitochondrial dysfunction through the generation of reactive oxygen species (ROS), leading to apoptosis in infected cells. It exhibits potent lethality against L. donovani with an IC50 value of 4.54 µM, while displaying low cytotoxicity towards J774.1 macrophages. Antileishmanial agent-36 is suitable for research applications focused on visceral leishmaniasis (VL) and parasite burden clearance. -
Parasite Inhibitor
Quinacrine acetate is a potent modulator of the cGAS-STING-TBK1 signaling pathway, exhibiting notable immune stimulatory activity. This compound has been investigated for its therapeutic potential in enhancing anti-tumor immunity and improving the efficacy of cancer immunotherapies by addressing the immunogenicity challenges faced by various tumors. Quinacrine acetate also represents a promising approach to mitigate the limitations associated with immune checkpoint inhibitors in cancer treatment. -
Antileishmanial Agent
PT4 is an antileishmanial agent specifically effective against cutaneous leishmaniasis. It exhibits significant activity against both Leishmania species, with IC50 values of 125.18 µM for L. amazonensis and 233.18 µM for L. braziliensis. PT4 induces a reduction in mitochondrial membrane potential and elevates reactive oxygen species production, resulting in parasite lethality. Additionally, PT4 demonstrates potent in vivo anti-inflammatory properties, making it a valuable tool for research in leishmaniasis and related inflammatory conditions. -
Antileishmanial Agent
Antileishmanial agent-35 is a potent antileishmanial compound that targets Leishmania amazonensis, exhibiting an IC50 of 0.29 μM against promastigotes. This compound disrupts mitochondrial function by lowering the mitochondrial membrane potential and ATP levels, while also enhancing reactive oxygen species (ROS) production due to interference with the electron transport chain. Antileishmanial agent-35 is suitable for research focused on cutaneous leishmaniasis and its underlying mechanisms of action. -
Derivative of artemisinin
Artemether has been shown to have significant anticancer and antitumor activities. It is demonstrated that artemether caused strong inhibitory effects on brain glioma growth and angiogenesis in rats. -
nitroimidazole antibiotic medication
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. - Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.
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broad-spectrum seed treatment nematicide
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton. -
anti-infective agent
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities. -
strigolactone (SL) antagonist
Soporidine is a strigolactone (SL) antagonist and inhibitor of germination in their biological assays. It binds AtHTL and specifically interferes with SL signaling. -
cell permeable TgPrxII inhibitor
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). -
anti-inflammatory agent
Cepharanthine is an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. -
Antihelminthic Agent
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Fluorescent Dye
Acridine Orange base is a cell-permeable fluorescent dye primarily utilized for staining nucleic acids in various organisms, including bacteria, parasites, and viruses. This dye exhibits distinct fluorescence characteristics; it emits green light when bound to double-stranded DNA (Ex=488 nm, Em=520-524 nm) and red light when associated with single-stranded DNA or RNA (Ex=457 nm, Em=630-644 nm). Acridine Orange base is particularly valuable in fluorescence microscopy for distinguishing human cells under acidic conditions (pH=3.5) and is widely employed in cell cycle assays. -
Photobase Reagent
Malachite Green Carbinol Base acts as a photobase reagent, capable of releasing hydroxide ions (OH-) upon ultraviolet light irradiation. This reaction facilitates a progressive shift in pH levels, allowing for precise pH regulation in experimental settings. When exposed to high-intensity UV light (500 W, 50 W/cm), the solution transitions rapidly from colorless to deep green, which can be utilized for applications in photochemistry and environmental monitoring. -
Sulfaquinoxaline is a veterinary antimicrobial agent effective against a broad spectrum of Gram-negative and Gram-positive bacteria. It is commonly used for the prevention and treatment of coccidiosis and bacterial infections in livestock and poultry.
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Parasite Inhibitor
Isopimpinellin acts as a potent inhibitor of parasitic activity. Isolated from Glomerella cingulata, this orally active compound prevents DNA adduct formation and inhibits skin tumor initiation induced by 7,12-dimethylbenz[a]anthracene. Additionally, Isopimpinellin demonstrates significant anti-leishmania activity, making it a valuable reagent for studies in parasitology and cancer research. -
Parasite Inhibitor
5,7,3',4'-Tetramethoxyflavone is a polymethoxyflavone that acts as a potent inhibitor of parasitic activity. Isolated from M. exotica, this compound demonstrates a range of bioactivities, including antifungal, antimalarial, antimycobacterial, and anti-inflammatory effects. Additionally, 5,7,3',4'-Tetramethoxyflavone exerts chondroprotective effects through modulation of β-catenin signaling, making it a valuable tool for research in both parasitology and inflammatory conditions. -
Parasite Inhibitor
Dihydroartemisinic acid, a biosynthetic precursor to the antimalarial compound Artemisinin, functions primarily as a parasite inhibitor. This compound demonstrates potent activity against malaria-causing Plasmodium species, making it valuable for research in malaria treatment and drug development. Its role in synthesizing Artemisinin positions it as an important reagent for studies focusing on antimalarial therapies. -
Parasite Inhibitor
Pervicoside B is a glycoside C derived from the sea cucumber Neothyone gibbosa, exhibiting potent antiparasitic activity as it effectively inhibits Leishmania mexicana promastigotes at concentrations of 5-10 μg/mL. Additionally, Pervicoside B displays significant antifungal properties against Aspergillus niger, with minimum inhibitory concentration (MIC) values ranging from 4.65 to 16.7 μg/mL. This compound holds promise for research applications focused on addressing parasitic infections and fungal diseases.
