MONIRO-1 is a selective inhibitor of T-type and N-type calcium channels, demonstrating IC50 values of 34 µM, 3.3 µM, 1.7 µM, and 7.2 µM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3, respectively, while exhibiting minimal activity against L-type calcium channels. Its ability to modulate calcium influx makes MONIRO-1 a valuable tool for research into pain pathways and epilepsy mechanisms. This compound is instrumental for studies focused on the pharmacological modulation of calcium channels in neuronal excitability.
MONIRO-1 is a selective inhibitor of T-type and N-type calcium channels, demonstrating IC50 values of 34 µM, 3.3 µM, 1.7 µM, and 7.2 µM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3, respectively, while exhibiting minimal activity against L-type calcium channels. Its ability to modulate calcium influx makes MONIRO-1 a valuable tool for research into pain pathways and epilepsy mechanisms. This compound is instrumental for studies focused on the pharmacological modulation of calcium channels in neuronal excitability.
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