MPT0G211 is a highly potent, orally bioavailable, and selective histone deacetylase 6 (HDAC6) inhibitor, with an IC₅₀ of 0.291 nM and over 1000-fold selectivity against other HDAC isoforms. It efficiently crosses the blood–brain barrier and demonstrates neuroprotective effects by reducing tau phosphorylation and improving cognitive function in Alzheimer's disease models. Additionally, MPT0G211 exhibits anti-metastatic and anticancer activities, making it a promising therapeutic candidate for both neurodegenerative disorders and oncology research.
MPT0G211 is a highly potent, orally bioavailable, and selective histone deacetylase 6 (HDAC6) inhibitor, with an IC₅₀ of 0.291 nM and over 1000-fold selectivity against other HDAC isoforms. It efficiently crosses the blood–brain barrier and demonstrates neuroprotective effects by reducing tau phosphorylation and improving cognitive function in Alzheimer's disease models. Additionally, MPT0G211 exhibits anti-metastatic and anticancer activities, making it a promising therapeutic candidate for both neurodegenerative disorders and oncology research.
Product Information
Catalog Num
A24061
Formula
C17H15N3O2
Molecular Weight
293.32
CAS Number
2151853-97-1
SMILES
O=C(NO)C1=CC=C(CNC2=C3N=CC=CC3=CC=C2)C=C1
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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