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- Vivek Bora, .et al. Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia, Can J Physiol Pharmacol, 2021, 6 October
- Taito Kashio, .et al. HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells, Tissue Barriers, 2021, May 6;1911195 PMID: 33955828
- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- Arshdeep Singh, .et al. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition, Eur J Med Chem, 2021, Apr 5;215:113169 PMID: 33588178
- Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096
Biological Activity
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
Targets
| HDAC1 (Cell-free assay) | HDAC3 (Cell-free assay) | |||
| 0.51 μM | 1.7 μM |
| In vitro (25°C) | DMSO | 71 mg/mL (188.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.57 mL | 132.84 mL | 265.67 mL |
| 0.5 mM | 5.31 mL | 26.57 mL | 53.13 mL |
| 1 mM | 2.66 mL | 13.28 mL | 26.57 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
*The above data is based on the productmolecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10611 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 209783-80-2 |
| Formula | C21H20N4O3 |
| M. Wt | 376.4 |
| Purity | >98% |
| Synonyms | SNDX-275 |
| SMILES | C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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