MS-275 (Entinostat)

Catalog No.: A10611

HDAC inhibitor

MS-275 (Entinostat)

MS-275 (Entinostat) Chemical Structure

CAS NO. 209783-80-2

MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$70.00
50 mg
$90.00
200 mg
$190.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096

Biological Activity

MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
Targets
HDAC1 (Cell-free assay) HDAC3 (Cell-free assay)
0.51 μM1.7 μM
In vitro (25°C) DMSO 71 mg/mL (188.62 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.57 mL 132.84 mL 265.67 mL
0.5 mM 5.31 mL 26.57 mL 53.13 mL
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL

*The above data is based on the productmolecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10611
Actions Inhibitor
CAS No. 209783-80-2
Formula C21H20N4O3
M. Wt 376.4
Purity >98%
Synonyms SNDX-275
SMILES C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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