MS432

Name: MS432
Brand: Adooq Bioscience
SKU: A23942
Rating: 5 (288 reviews)

Catalog No.: A23942

PROTAC MEK1/2 Degrader

MS432 is a first-in-class, highly selective PROTAC degrader targeting MEK1 and MEK2, based on PD0325901 and a von Hippel-Lindau (VHL) E3 ligase ligand. It demonstrates favorable plasma exposure in mice and induces MEK1 and MEK2 degradation in HT29 cells with DC₅₀ values of 31 nM and 17 nM, respectively.

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MS432 2672512-44-4 PROTAC MEK1/2 Degrader

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Grouped product items
Size	Price	Stock
5mg	$585.00	In stock
10mg	$1,008.00	In stock
50mg	$2,990.00	In stock
100mg	$5,850.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	MS432 is a first-in-class, highly selective PROTAC degrader targeting MEK1 and MEK2, based on PD0325901 and a von Hippel-Lindau (VHL) E3 ligase ligand. It demonstrates favorable plasma exposure in mice and induces MEK1 and MEK2 degradation in HT29 cells with DC₅₀ values of 31 nM and 17 nM, respectively.

Product Information

Catalog Num	A23942
Formula	C50H65F3IN7O6S
Molecular Weight	1076.06
CAS Number	2672512-44-4
SMILES	O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](O)C1)N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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