MS98 is a selective PROTAC degrader targeting AKT, effectively inducing the degradation of total AKT (T-AKT) with a DC50 value of 78 nM. This compound demonstrates high-affinity binding to AKT isoforms, with Kd values of 4 nM, 140 nM, and 8.1 nM for AKT1, AKT2, and AKT3, respectively. MS98 is valuable for research applications in understanding AKT signaling pathways and developing therapeutic strategies for cancer and other diseases associated with dysregulated AKT activity.
MS98 is a selective PROTAC degrader targeting AKT, effectively inducing the degradation of total AKT (T-AKT) with a DC50 value of 78 nM. This compound demonstrates high-affinity binding to AKT isoforms, with Kd values of 4 nM, 140 nM, and 8.1 nM for AKT1, AKT2, and AKT3, respectively. MS98 is valuable for research applications in understanding AKT signaling pathways and developing therapeutic strategies for cancer and other diseases associated with dysregulated AKT activity.
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