N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies.
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies.
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