N-(Acid-PEG2)-N-bis(PEG3-azide) serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development.
N-(Acid-PEG2)-N-bis(PEG3-azide) serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development.
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