N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through the azide group. This compound participates in click chemistry, specifically through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized entities, making it a versatile tool for targeted protein degradation studies and other bioconjugation applications.
N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through the azide group. This compound participates in click chemistry, specifically through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized entities, making it a versatile tool for targeted protein degradation studies and other bioconjugation applications.
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