N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It provides a versatile approach for researchers developing PROTACs, facilitating targeted protein degradation in various biological applications.
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It provides a versatile approach for researchers developing PROTACs, facilitating targeted protein degradation in various biological applications.
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