N-Boc-N-bis(C2-PEG1-azide) is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) when paired with alkyne-containing moieties. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, providing versatile coupling options for bioconjugation and targeting studies in chemical biology.
N-Boc-N-bis(C2-PEG1-azide) is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) when paired with alkyne-containing moieties. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, providing versatile coupling options for bioconjugation and targeting studies in chemical biology.
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