N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies.
N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies.
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