Naratuximab emtansine is a CD37-targeted antibody-drug conjugate (ADC) that combines a humanized IgG1 monoclonal antibody with the microtubule disruptor DM1. This compound exhibits high affinity and specificity for the CD37 antigen, facilitating internalization and subsequent release of DM1 intracellularly. By disrupting microtubule assembly, Naratuximab emtansine leads to cell cycle arrest and apoptosis, making it a valuable tool for research in targeted cancer therapies and hematological malignancies.
Naratuximab emtansine is a CD37-targeted antibody-drug conjugate (ADC) that combines a humanized IgG1 monoclonal antibody with the microtubule disruptor DM1. This compound exhibits high affinity and specificity for the CD37 antigen, facilitating internalization and subsequent release of DM1 intracellularly. By disrupting microtubule assembly, Naratuximab emtansine leads to cell cycle arrest and apoptosis, making it a valuable tool for research in targeted cancer therapies and hematological malignancies.
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