Catalog No.
Product Name
Application
Product Information
Citations
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Calcineurin Inhibitor
Mevalonolactone is a sesquiterpene lactone that acts as a calcineurin inhibitor, demonstrating inhibitory activity with an IC50 value of 134.29 μM against p-Nitrophenyl phosphate. This compound is primarily used in research exploring cellular signaling pathways, immune response modulation, and potential therapeutic applications for disorders involving calcineurin activity. Its ability to inhibit calcineurin makes it valuable for investigations into T cell activation and cytokine production. -
Calcineurin NFAT Inhibitor
NFAT Inhibitor-2 is a selective inhibitor of calcineurin, targeting the calcium-regulated NFAT signaling pathway. This compound demonstrates significant potential in research related to inflammatory diseases, autoimmune disorders, cardiovascular conditions, neurodegenerative diseases, and disorders characterized by uncontrolled cell proliferation or differentiation. Additionally, NFAT Inhibitor-2 may provide insights into angiogenesis-related diseases, allergies, anaphylaxis, and alopecia. -
Antioxidant Agent
6,4'-Dihydroxy-7-methoxyflavanone is a flavonoid with notable antioxidant properties. This compound effectively inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis, making it a valuable tool in bone health research. Additionally, it exhibits anti-inflammatory and neuroprotective effects, supporting its utility in studies related to osteoporosis and neurodegenerative diseases. -
CaMK1D Inhibitor
CS587 is a selective inhibitor of Calcium/calmodulin-dependent protein kinase 1D (CaMK1D), demonstrating neurocytotoxic effects at concentrations of 10 μM. This compound modulates neuronal cell sensitivity to amyloid-beta (Aβ) oligomer toxicity, making it a valuable tool for studying neurodegenerative disorders and related cellular pathways. Its specificity and mechanism of action position CS587 as a significant reagent for research into neuronal health and disease mechanisms. -
Calmodulin Antagonist
W-13 hydrochloride is a calmodulin antagonist that effectively disrupts calmodulin-mediated signaling pathways. This compound has demonstrated the ability to inhibit the growth of Tamoxifen-resistant human breast cancer cells, making it a valuable tool for cancer research. Its mechanism of action provides insights into potential therapeutic strategies for overcoming resistance in breast cancer treatment. -
CaMKIIδ Inhibitor
CaMKIIδ-IN-1 is a potent inhibitor of calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) with an IC50 of 12 nM. This pyrimidine-based compound is valuable for studying the role of CaMKIIδ in various cellular processes, including synaptic plasticity and cardiac function. Its selective inhibition makes it a useful tool for investigating the biochemical pathways regulated by CaMKIIδ in both physiological and pathological contexts. -
CaMKK Inhibitor
TIM-063 is a selective, cell-permeable CaMKK inhibitor that functions as an ATP-competitive antagonist, specifically targeting the catalytic domain of CaMKK. It exhibits Ki values of 0.35 μM for CaMKKα and 0.2 μM for CaMKKβ, with corresponding IC50 values of 0.63 μM and 0.96 μM. This compound is useful for exploring CaMKK-mediated signaling pathways and evaluating its potential therapeutic applications in various cellular models. -
CaMKIIα Inhibitor
CaMKIIα-IN-1 is an orally active inhibitor of calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα), exhibiting a dissociation constant (KD) of 219 nM for the wild-type hub. This compound demonstrates good metabolic stability, making it suitable for in vivo studies. It can be utilized in research focused on CaMKIIα-mediated pathways, with applications in understanding neurological diseases and cellular signaling mechanisms. -
Diversity-Oriented Synthesis
BRD0418 is a diversity-oriented synthesis molecule that targets tribbles pseudokinase 1, influencing its expression. This compound has been shown to modulate lipoprotein metabolism, facilitating the transition from fat production to clearance. BRD0418 is valuable in research applications related to coronary artery disease (CAD), providing insights into metabolic regulation and cardiovascular health. -
CaMKIIα Ligand
PTCA is a potent ligand for calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα), exhibiting a pKi value of 7.2. This compound effectively modulates CaMKIIα activity, making it valuable for research into calcium signaling pathways and their implications in neuronal functions and synaptic plasticity. Its use in biochemical assays facilitates the exploration of CaMKIIα's role in various physiological and pathological processes. -
CaMKIIα Modulator
Ph-HTBA is a selective modulator of CaMKIIα, exhibiting a high binding affinity with a Kd value of 757 nM. This compound effectively penetrates the blood-brain barrier, making it suitable for studying neurological conditions. Its applications include research into ischemia and neurodegenerative disorders, offering potential insights into therapeutic interventions for these diseases. -
CaMK Substrate
Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide designed as a substrate for calmodulin-dependent protein kinases (CaMKs) that are activated by calcium ions (Ca2+) and calmodulin (CaM). This substrate is crucial for studying the phosphorylation activity of CaMKs and aids in understanding their role in various cellular signaling pathways. It is relevant for research applications in signal transduction and regulatory mechanisms in calcium signaling. -
CaMKII Substrate
Autocamtide-3 is a selective substrate for Ca2+/calmodulin-dependent kinase II (CaMKII), characterized by its 13-amino-acid sequence that includes the phosphorylatable residue Thr287. This peptide serves as a valuable tool for studying the activation and regulation of CaMKII in various biological contexts. Its application in research encompasses investigations into calcium signaling, neuronal function, and cardiac physiology. -
CaMKIIα inhibitor
HOCPCA is a selective inhibitor of CaMKIIα, a key regulator of calcium-dependent signaling pathways. This compound exhibits neuroprotective properties, enhancing sensorimotor functions and promoting hippocampal neuronal activity following experimental stroke in murine models. It effectively modulates abnormal CaMKII signaling, normalizes Thr286 autophosphorylation post-ischemia, and downregulates specific active CaMKII fragments associated with ischemic conditions. Additionally, HOCPCA demonstrates superior binding affinity to the GHB site, alongside excellent blood-brain barrier permeability, making it a valuable tool for research into neuroprotection and cognitive function. -
CaMKII Inhibitor
CaMKII-IN-3 is a potent inhibitor of Calcium/Calmodulin-dependent protein kinase II (CaMKII), demonstrating an IC50 of less than 10 nM. This compound is valuable in research focused on the role of CaMKII in cardiac function and related heart diseases. Its application may provide insights into disease mechanisms and potential therapeutic strategies. -
CaMKII Inhibitor
Protein kinase inhibitor 8 (Compound CK59) is a selective inhibitor of calmodulin-dependent protein kinase II (CaMKII). This compound effectively reduces cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and mitigates the downregulation of GLT-1 expression, leading to decreased neuronal damage. Protein kinase inhibitor 8 is a valuable tool for research into neurodegenerative diseases and the molecular mechanisms underlying neuronal stress responses. -
CaMK Substrate
Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide designed as a substrate for calmodulin-dependent protein kinases (CaMK). As a Ca2+- and calmodulin-dependent substrate, it facilitates the study of CaMK activity and regulation in cellular signaling pathways. This analog is valuable for investigating phosphorylation processes and the role of CaMK in various biological systems, making it a useful tool in biochemical and pharmacological research. -
CaMKIIα Degrader
CaMKIIα-PHOTAC is a photochemically targeted chimera designed to selectively degrade Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Upon exposure to specific wavelengths of light, this compound facilitates the ubiquitination and subsequent degradation of CaMKIIα through the endogenous proteasome pathway. Its application has demonstrated a reduction in synaptic function, notably diminishing the amplitude of evoked field excitatory postsynaptic potentials in the mouse hippocampus, thereby implicating its role in the modulation of long-term potentiation and memory processes in dendritic regions. -
Chromogenic Substrate
Ac-IEAR-pNA is a chromogenic substrate specifically designed for the quantification of endotoxin levels. It serves as a selective substrate for human butyrylcholinesterase (HuBChE), resulting in the cleavage that releases p-nitroaniline, a measurable product. This compound is widely used in research applications focused on endotoxin detection and related studies in immunology and toxicology. -
Acetylcholinesterase Inhibitor
TAK-802 is a potent orally active inhibitor of acetylcholinesterase, a key enzyme in neurotransmitter regulation. This compound demonstrates significant nonlinear pharmacokinetics, with its distribution in red blood cells showing concentration-dependent behavior. TAK-802 is primarily utilized in research applications focused on neurodegenerative disorders and cognitive function enhancement. -
Muscarinic Antagonist
Chlorpyrifos is a muscarinic antagonist and neurotoxic insecticide classified as a thionite ester. This compound acts primarily as an acetylcholinesterase (AChE) inhibitor, disrupting neurological function in various organisms, including insects and mammals. Research applications of Chlorpyrifos include investigations into neurodevelopmental effects, synaptic transmission alterations, and associated toxicological studies. -
Transporter Inhibitor
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU), exhibiting a Ki value of 25 nM. It acts as a neuromuscular blocking agent by inhibiting both the synthesis and release of acetylcholine (ACh). Hemicholinium 3 demonstrates key biological activities, including the inhibition of Epibatidine-induced contraction and [3H]acetylcholine release, with IC50 values of 897 nM and 693 nM, respectively. This compound is useful in research applications focused on neurotransmitter modulation and neuromuscular transmission studies. -
BuChE inhibitor
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of butyrylcholinesterase (BuChE), functioning through irreversible inhibition. This compound is primarily utilized in research to investigate the mechanisms of BuChE and the resulting effects on acetylcholine metabolism. Iso-OMPA has been shown to enhance soman toxicity in rat models, linked to the inhibition of plasma carboxylesterase (CarbE), making it a valuable tool in studies of nerve agent effects and cholinergic signaling. -
Acetylcholinesterase
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a crucial cholinergic enzyme that functions at neuromuscular junctions and cholinergic synapses. This enzyme catalyzes the hydrolysis of acetylcholine and other choline esters, leading to the production of acetate and choline. Its primary biological activity involves the termination of neuronal transmission, ensuring precise signaling by preventing excessive acetylcholine activation at synaptic sites. Acetylcholinesterase, Fly head is essential for studies exploring synaptic function, cholinergic signaling, and neuromuscular disorders. -
Phosphorylating Agent
Chlorpyrifos-oxon is a potent phosphorylating agent primarily known for its ability to inhibit acetylcholinesterase (AChE). This active metabolite of Chlorpyrifos can induce cross-linking of tubulin subunits, leading to significant disruption of microtubule function. Its biological activity provides valuable insights into neurotoxic mechanisms and potential pathways for studying neurodegenerative diseases. -
Neurotoxin
(-)-Carvone is a neurotoxin that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This compound is utilized primarily for its biological activity as a bird repellent, as well as its ability to inhibit larval growth, reduce pupation rates, and increase larval mortality. Research applications include studies on insect neurobiology and pest control strategies. -
Cholinesterase (ChE) Inhibitor
Physostigmine salicylate is a reversible acetylcholinesterase (AChE) inhibitor that effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission. It has demonstrated the ability to reverse memory deficits in transgenic mice models of Alzheimer's disease, making it a valuable tool in neurodegeneration research. Additionally, Physostigmine salicylate serves as an antidote for anticholinergic poisoning, highlighting its significance in pharmacological studies and therapeutic applications. -
AChE Inhibitor
Tacrine is a potent acetylcholinesterase (AChE) inhibitor, with an IC50 value of 109 nM. This compound is recognized for its ability to ameliorate cognitive deficits, particularly in aged rodent models. Additionally, Tacrine is associated with potential hepatotoxicity and is frequently utilized in research focusing on Alzheimer's disease and related neurodegenerative disorders. -
Antioxidant Agent
Cyanidin-3-O-galactoside chloride is an antioxidant agent that demonstrates significant potential in mitigating oxidative stress. Extracted from hawthorn fruit peel, this compound is known for its ability to inhibit acetylcholinesterase (AChE) activity. Its biological activities make it valuable for research in neuroprotective studies and the exploration of therapeutic applications in neurodegenerative diseases. -
Cholinesterase (ChE) Inhibitor
Chavicol, a cholinesterase (ChE) inhibitor, demonstrates potent inhibition of acetylcholinesterase, with an IC50 of 7.42 μM. This compound exhibits anti-cancer properties, effectively suppressing the growth, survival, migration, and invasion of various cancer cell lines. Notably, Chavicol shows significant cytotoxic effects, evidenced by a notable concentration of approximately 31 μg/mL in A-549 cells. Its dual activities underscore its potential utility in cancer research and therapeutic development. -
Cholinesterase (ChE) Inhibitor
Physostigmine hemisulfate is a reversible inhibitor of acetylcholinesterase (AChE), effectively enhancing cholinergic neurotransmission by crossing the blood-brain barrier. This compound has demonstrated the ability to reverse cognitive deficits in transgenic mouse models of Alzheimer's disease, making it a valuable tool for neurological research. Additionally, Physostigmine hemisulfate serves as an antidote for anticholinergic poisoning, underscoring its significance in pharmacological studies and clinical applications. -
Acetylcholinesterase Inhibitor
N-Boc-4-piperidinemethanol is an acetylcholinesterase (AChE) inhibitor that serves as a valuable tool for neurological research. It is particularly relevant in studies focused on Alzheimer's Disease, aiding in the investigation of cholinergic dysfunction. This compound may contribute to the development of therapeutic strategies targeting AChE activity. -
Insecticide
Profenofos is an insecticide that functions as an acetylcholinesterase (AChE) inhibitor, leading to neurotoxicity in target pest species. Its primary mechanism involves the inhibition of AChE, resulting in the accumulation of acetylcholine at synapses, which disrupts normal neural function. Profenofos is effective for the control of a wide range of insect pests on field crops, vegetables, and fruit crops, making it valuable for agricultural research and pest management studies. -
Cholinesterase
Cholinesterase, Horse serum is a catalytic enzyme comprising acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). These enzymes facilitate the hydrolysis of various substrates, including the hydrolysis of 6-monoacetylmorphine (6-MAM) to morphine. This reagent is valuable in biochemical research, particularly in studies involving neurotransmitter metabolism and the pharmacokinetics of opioid compounds. -
CYP2D6/AChE Inhibitor
Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies. -
Antidote
Obidoxime dichloride is a potent antidote that acts primarily as a reactivator of acetylcholinesterase (AChE) inhibited by organophosphate compounds, such as sarin. By effectively restoring AChE activity, it mitigates the toxic effects associated with nerve agent exposure. Obidoxime dichloride is widely utilized in research focused on the effects of organophosphate poisoning and the development of therapeutic countermeasures. -
Insecticide
Acephate is a broad-spectrum anticholinesterase insecticide that functions by inhibiting acetylcholinesterase (AChE) activity in insects. This inhibition disrupts neurotransmission, leading to the effective control of various insect species. Acephate is widely utilized in agricultural and horticultural applications to manage pest populations, thereby enhancing crop yield and quality. -
Cholinesterase (ChE) Inhibitor
Violanthin is a cholinesterase (ChE) inhibitor derived from the stems of Dendrobium officinale. It exhibits significant antioxidant and antibacterial properties, making it a valuable compound for biological research. Violanthin effectively inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM, indicating its potential application in studies related to neurodegenerative diseases and cholinergic signaling. -
Stable Isotope
Pyridostigmine-d6 bromide is a deuterated form of Pyridostigmine, functioning as a reversible cholinesterase inhibitor and parasympathomimetic agent. This stable isotope is useful for metabolic studies and tracking the pharmacokinetics of drugs in biological systems. Its labeling with deuterium allows for enhanced precision in mass spectrometry applications and other analytical techniques in chemical research. -
Cationic Charged Quencher
p-Xylene bis(pyridinium bromide) serves as a cationic charged quencher. This compound exhibits inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 1540 μM and 529 μM, respectively. It is suitable for research applications focusing on cholinergic signaling and enzyme inhibition studies. -
AChE Inhibitor
AChE-IN-84 is a potent inhibitor of acetylcholinesterase (AChE), a key enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. This compound demonstrates significant biological activity in modulating cholinergic signaling pathways, making it an essential tool for studying neurodegenerative diseases such as Alzheimer's. AChE-IN-84 is useful in research applications focusing on cognitive enhancement and synaptic function restoration. -
Cholinesterase (ChE) Inhibitor
Phenthoate is a cholinesterase (ChE) inhibitor that functions primarily as an organophosphorus pesticide. This compound demonstrates low toxicity in animals while effectively inhibiting acetylcholinesterase (AChE), which can provide insights into neurotoxicity and enzyme regulation. Phenthoate is widely used in research applications examining the biochemical pathways of neurotransmission and potential environmental impacts of pesticide exposure. -
AChE/BchE Inhibitor
ACG548B is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 1.78 µM and 0.496 µM, respectively. It exhibits strong affinity and selectivity for AChE over BChE and choline kinase (ChoK). ACG548B is suitable for research applications focused on myasthenia gravis and the mechanisms of neuromuscular blockade. -
AChE Inhibitor
Pseudocoptisine chloride is a quaternary alkaloid derived from the benzylisoquinoline structure, isolated from Corydalis tuber. This compound functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 12.8 μM. Pseudocoptisine chloride exhibits notable anti-inflammatory and anti-amnestic properties, making it a valuable reagent for research related to neurodegenerative diseases and cognitive function studies. -
Anti-inflammatory Agent
Manghaslin is a flavonoid glycoside that serves as an anti-inflammatory agent. It exhibits inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 94.92 μM. This compound is relevant for research into the modulation of inflammation and potential neuroprotective effects. -
Nematicide
Fosthiazate is a broad-spectrum nematicide that primarily targets plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp. Its mechanism of action involves the inhibition of acetylcholinesterase synthesis, disrupting neurotransmitter regulation in nematodes. This compound is utilized in agricultural research to manage nematode populations effectively and enhance crop health. -
AChE Substrate
1-Naphthyl acetate serves as a chromogenic substrate specifically for the detection of acetylcholinesterase (AChE) activity in erythrocytes. This compound is particularly valuable in research related to organophosphorus pesticide poisoning, enabling the assessment of enzymatic activity and its inhibition. Its colorimetric properties facilitate quantitative analysis in various biochemical studies. -
Cholinesterase (ChE) Inhibitor
Dehydronuciferine acts as an inhibitor of cholinesterase, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 25 μg/mL. This compound is derived from the leaves of Nelumbo nucifera (lotus) and demonstrates potential in research applications related to neurodegenerative diseases and cognitive disorders. Its ability to modulate cholinergic signaling makes it a valuable tool for studying cholinergic system functions and developing therapeutic strategies. -
Cholinesterase (ChE) Inhibitor
Galanthaminone is a competitive and reversible inhibitor of cholinesterase (ChE), primarily targeting acetylcholinesterase (AChE). This compound demonstrates significant biological activity in enhancing cholinergic transmission and is utilized in the study of mild to moderate Alzheimer's disease and related memory impairments. Its application in research aids in understanding the mechanisms underlying cognitive decline and potential therapeutic interventions. -
Cholinesterase (ChE) Inhibitor
Picfeltarraenin IB is a triterpenoid derived from Picria fel-terrae Lour that acts as a cholinesterase (ChE) inhibitor. This compound exhibits significant biological activity by inhibiting acetylcholinesterase (AChE), thereby modulating cholinergic signaling. It is primarily utilized in research settings focusing on therapeutic applications for herpes infections, cancer, and inflammation.
