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Catalog No.
Product Name
Application
Product Information
Citations
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NF-κB Inhibitor
Suberosin is a potent NF-κB inhibitor derived from Plumbago zeylanica. It demonstrates significant anti-inflammatory and anticoagulant properties by suppressing PHA-induced proliferation of peripheral blood mononuclear cells (PBMC) and inhibiting cell cycle progression from the G1 phase to the S phase. Due to its ability to modulate the transcription factors NF-AT and NF-κB, Suberosin serves as a valuable tool in studies of inflammation and thrombosis. -
NF- B Inhibitor
2,4,6-Trihydroxybenzaldehyde is an orally active inhibitor of NF-κB, a key transcription factor involved in inflammatory and immune responses. This compound exhibits notable anti-tumor activity, inhibits cancer cell proliferation, and demonstrates anti-obesity effects. Its applications in cancer research and metabolic studies make it a valuable reagent for exploring mechanisms of disease and potential therapeutic strategies. -
NF-κB Inhibitor
Lucyoside B is a potent NF-κB inhibitor that effectively modulates inflammatory responses. It inhibits the production of various inflammatory mediators through the NF-κB and activator protein-1 signaling pathways in activated macrophages. This compound is valuable for research applications focused on understanding inflammation and its modulation in various disease states. -
OST-A Inhibitor
NGI-235 is a selective inhibitor of the OST-A enzyme, effectively blocking the glycosylation of Toll-like receptor 4 (TLR4). This compound demonstrates potent inhibition of NF-κB inflammatory signaling, making it a valuable tool for investigating mechanisms of inflammation and immune response regulation. NGI-235 is suitable for research applications focused on inflammatory diseases and TLR4-mediated pathways. -
NIK Inhibitor
NIK-IN-2 is a potent inhibitor of NF-κB-inducing kinase (NIK), exhibiting an impressive pIC50 of 7.4. This compound serves as a valuable tool in cancer research, enabling the investigation of NIK's role in NF-κB signaling pathways and their implications in tumorigenesis. Its selective inhibition of NIK provides insights into therapeutic strategies targeting NF-κB-related diseases. -
NF-κB Inhibitor
9-Hydroxycanthin-6-one is an alkaloid that functions as an NF-κB inhibitor, exhibiting significant biological activity. With an IC50 value of 3.8 μM, this compound effectively modulates the NF-κB signaling pathway. It offers potential applications in research related to inflammation, cancer, and other diseases driven by NF-κB activation. -
NF-κB Inhibitor
NBD peptide is a selective inhibitor of the NF-κB signaling pathway, acting by disrupting the interaction between NEMO and the IKK complex. This inhibition leads to reduced production of pro-inflammatory cytokines, showcasing its anti-inflammatory properties. Additionally, NBD peptide demonstrates immunosuppressive effects through modulation of immune cell activity. The incorporation of the cell-penetrating HIV-TAT peptide enhances its cellular uptake, facilitating its application in various research contexts. -
BRD4 BD2 Inhibitor
BRD4-BD1/2-IN-3 is a selective inhibitor of the BRD4 bromodomain 2 (BD2), exhibiting an IC50 of 0.41 nM for BRD4 BD2 compared to BRD4 BD1. This compound effectively inhibits LPS-induced expression of IL-6, demonstrating significant anti-inflammatory properties through modulation of the TNF and NF-κB signaling pathways. BRD4-BD1/2-IN-3 is valuable for research focused on inflammatory diseases. -
NF-κB Inhibitor
HSR1304 is a potent NF-κB inhibitor that targets the multifunctional transcription factor involved in various human diseases, including cancer and chronic inflammation. This compound demonstrates significant biological activity in modulating NF-κB signaling pathways. HSR1304 is intended for research applications focused on cancer biology and the development of anti-inflammatory strategies. -
NF-κB Inhibitor
Rubioncolin C is a potent NF-κB inhibitor that demonstrates significant anti-tumor activity. It promotes apoptotic and autophagic cell death in human cancer cells while effectively suppressing the NF-κB and Akt/mTOR/P70S6K signaling pathways. This compound is valuable for research focused on cancer biology and therapeutic development. -
NF-κB Inhibitor
(−)-N-Hydroxyapiosporamide is a potent NF-κB inhibitor known for its significant antitumor activity both in vitro and in vivo. Its biological properties make it particularly relevant for research applications targeting colorectal cancer (CRC). This alkaloid serves as a valuable tool for studying the mechanisms of NF-κB signaling and its role in tumor progression. -
NF-κB Inhibitor
NF-κB-IN-3 is a potent NF-κB inhibitor with an IC50 of 0.70 µM. It exhibits significant biological activity by disrupting the NF-κB signaling pathway, which is crucial in various cellular processes including inflammation and cancer progression. This compound is utilized in research applications focused on cancer biology and therapeutic interventions targeting NF-κB-related pathways. -
NF-κB Inhibitor
Stipuleanoside R2 is a potent inhibitor of NF-κB activation, specifically blocking the pathway triggered by TNFα. This compound demonstrates dose-dependent inhibitory activity, with an IC50 value of 4.1 μM. Stipuleanoside R2 can be utilized in research focused on inflammatory response, cancer biology, and other diseases associated with NF-κB signaling. -
NF-κB Inhibitor
Andrographolide-lipoic acid is an NF-κB inhibitor that combines Andrographolide and Lipoic acid. This compound exhibits significant anti-diabetic properties and provides protective effects on pancreatic β-cells. Its ability to modulate inflammatory pathways makes it a valuable tool for research in diabetes and related metabolic disorders. -
NF-κB Inhibitor
6-O-p-Hydroxybenzoylglutinoside is a selective NF-κB inhibitor that effectively suppresses TNF-α-activated NF-κB transcriptional activity, with an IC50 of 52.78 μM. This compound demonstrates targeted biological activity without significantly inhibiting soluble epoxide hydrolase (sEH), acetylcholinesterase (AChE), or butyrylcholinesterase (BChE). Isolated from the seeds of Catalpa bungei (Manchurian catalpa), 6-O-p-Hydroxybenzoylglutinoside is valuable for research applications focused on inflammation and signal transduction pathways. -
NF-κB Inhibitor
NF-κB-IN-10 is a potent inhibitor of the NF-κB signaling pathway, primarily targeting NF-κB activation. This compound has demonstrated the ability to alleviate heart failure by mitigating oxidative stress and inflammation through the modulation of the Nrf2/NF-κB axis. In RAW264.7 cells, NF-κB-IN-10 effectively inhibits lipopolysaccharide-induced nitric oxide production, as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This reagent is invaluable for research into cardiovascular diseases and related inflammatory processes. -
NF-κB Inhibitor
IKKγ NBD Inhibitory Peptide is a selective inhibitor of NF-κB signaling. It functions by disrupting the interaction between the IKKγ/NEMO-binding domain and IKKα/IKKβ, effectively blocking TNF-α-induced NF-κB activation. This peptide exhibits significant anti-inflammatory properties and has potential applications in studying cerebral ischemia and its associated neurological deficits. -
NF-κB Inhibitor
(Rac)-Myrislignan is a potent NF-κB inhibitor derived from Myristica fragrans Houtt. This compound demonstrates significant anti-inflammatory properties by effectively reducing LPS-induced inflammatory responses in murine macrophage cells. Its ability to inhibit the NF-κB signaling pathway makes (Rac)-Myrislignan a valuable tool for research into inflammation and related diseases. -
NF-κB Inhibitor
Helenalin isobutyrate is an NF-κB (p65 subunit) inhibitor known for its anti-inflammatory properties. It functions by irreversibly alkylating cysteine sulfhydryl groups within the p65 subunit, effectively diminishing the DNA binding activity of the NF-κB complex. This compound is valuable in research focused on understanding inflammation pathways and potential therapeutic interventions in related diseases. -
NF-κB Inhibitor
Sootepin D is a triterpene that serves as an NF-κB inhibitor. It effectively suppresses TNF-α-induced NF-κB activity with an IC50 of 8.3 μM, demonstrating significant anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
NIK Inhibitor
AM-0216 is a potent inhibitor of NF-κB-inducing kinase (NIK), exhibiting a Ki value of 2 nM. This compound selectively modulates NF-κB signaling pathways, making it valuable for investigating NF-κB-dependent hematologic malignancies, such as multiple myeloma, as well as autoimmune disorders. The specificity and efficacy of AM-0216 position it as a significant tool in the study of related therapeutic targets and disease mechanisms. -
NF-κB Inhibitor
NF-κB-IN-8 is a selective NF-κB inhibitor that competitively antagonizes lipopolysaccharide (LPS) binding to MD-2. This compound effectively reduces the expression of inflammatory mediators, making it a valuable tool for studying inflammatory responses. Additionally, NF-κB-IN-8 has been shown to inhibit alkaline phosphatase (ALP) activity. It is particularly relevant for research into inflammation-related conditions, such as acute lung injury (ALI). -
NF-κB p65 Inhibitor
Ratutrelvir is an NF-κB p65 inhibitor that targets the translocation of NF-κB p65 from the cytoplasm to the nucleus. By reducing phosphorylation levels of NF-κB p65 and IκBα, Ratutrelvir effectively inhibits the DNA-binding activity of NF-κB p65. This compound has been demonstrated to impair migration and invasion capabilities of breast cancer cells, as well as decrease their viability and colony-forming potential, making it a valuable tool for research in luminal A breast cancer. -
NF-κB Inhibitor
Laurotetanine is a potent isoquinoline alkaloid functioning as an NF-κB inhibitor. It exhibits anti-asthmatic properties by modulating immune responses, specifically inhibiting IgE and histamine release, alongside reducing inflammatory reactions. Laurotetanine's mechanism involves the downregulation of MUC5AC and NF-κB signaling pathways, making it a valuable tool for research in inflammatory diseases and asthma therapy. -
NF-κB Inhibitor
Dauricinoline is a potent orally active inhibitor of NF-κB, effectively blocking NF-κB activation induced by TNF-α. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating inflammatory diseases, particularly in the context of lung inflammation. Researchers may utilize Dauricinoline to explore the mechanisms underlying NF-κB-mediated signaling pathways and their role in various inflammatory conditions. -
NIK Inhibitor
NIK-IN-1 is a potent inhibitor of NF-κB-inducing kinase (NIK), a critical regulator in the NF-κB signaling pathway. This compound demonstrates significant anti-inflammatory activity and is utilized in research focused on hepatic inflammatory diseases and acute liver injury. Its application helps elucidate the role of NIK in liver pathology and potential therapeutic interventions. -
NF-κB Pathway Inhibitor
Pterocenoid C is a potent inhibitor of the NF-κB signaling pathway. This compound demonstrates significant biological activity by modulating inflammatory responses and has potential applications in the study of diseases associated with NF-κB dysregulation, including cancer and autoimmune disorders. Pterocenoid C serves as a valuable tool for researchers investigating the intricate roles of NF-κB in various biological processes and disease mechanisms. -
NF-κB Inhibitor
mcIRBP-9 is an orally bioavailable NF-κB inhibitor that effectively reduces pro-inflammatory cytokines such as TNF-α, IL-1β, and TGF-β1 in renal tissues. Additionally, mcIRBP-9 decreases LPS-induced production of IL-1β, making it a valuable tool for studying inflammatory processes. This compound is relevant to research focused on diabetic nephropathy and type 2 diabetes mellitus, providing insights into the underlying mechanisms of these conditions. -
NF-κB Inhibitor
NF-κB-IN-17 is an NF-κB inhibitor that effectively suppresses TNF-α-induced NF-κB DNA binding activity in C2C12 cells. Its mechanistic action provides valuable insights into the modulation of inflammatory responses, making it a useful tool for research applications focused on immune regulation and cancer biology. This reagent is suitable for studies examining the NF-κB signaling pathway and its implications in various disease models. -
NF-κB Inhibitor
Avenanthramide-C methyl ester is an NF-κB inhibitor that exerts anti-inflammatory effects by inhibiting the secretion of pro-inflammatory factors. This compound blocks NF-κB activation through the inhibition of IKK and IκB phosphorylation, as well as by impairing proteasome activity. Avenanthramide-C methyl ester is valuable for research applications focused on inflammation and related signaling pathways. -
NF-κB Inhibitor
Coronalolic acid acts as an NF-κB inhibitor, derived from the apical bud of Gardenia sootepenesis Hutch. This compound effectively suppresses TNF-α-induced NF-κB activation and inhibits nitric oxide (NO) production. It serves as a valuable tool for research applications focused on inflammation and immune response modulation. -
NF-κB Inhibitor
Myrcene-d6 functions as an NF-κB inhibitor through its deuterium labeling of the natural compound myrcene. With demonstrated efficacy in inhibiting TNFα and NF-κB activity, myrcene exhibits significant anti-invasive properties, mediates cell cycle arrest, and promotes apoptosis in cancer cells. Its biological activities also include robust blood protection and anti-inflammatory effects, making it a valuable reagent for research in cancer biology and inflammatory responses. -
NF-κB Inhibitor
NF-κB-IN-9 is a potent inhibitor of nuclear factor kappa B (NF-κB), functioning as a sonosensitizer with an excitation/emission wavelength of 489/628 nm. This compound exhibits significant inhibition of NF-κB signaling pathways, attributed to its dual resveratrol units. NF-κB-IN-9 demonstrates effective anti-tumor activity and exhibits pronounced sonocytotoxicity against various cancer cell lines. Additionally, NF-κB-IN-9 has shown favorable biosafety profiles in xenograft mouse models, making it a valuable tool for cancer research. -
NF-κB Inhibitor
Licoagrochalcone C is a flavonoid that serves as an effective inhibitor of NF-κB transcription. It demonstrates significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound is valuable for research applications focused on inflammatory responses and NF-κB-related signaling pathways. -
NF-κB Inhibitor
(R)-SEMBL is a potent inhibitor of the NF-κB signaling pathway. This compound exhibits significant biological activity in the modulation of inflammatory responses and has potential applications in cancer research, autoimmune diseases, and metabolic disorders such as diabetes. Additionally, (R)-SEMBL may be useful in investigating therapeutic strategies for cardiovascular diseases and complications associated with defective reperfusion injury. -
NF-κB Inhibitor
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene that acts as a nuclear factor kappa B (NF-κB) inhibitor. It effectively inhibits TNFα-triggered NF-κB activity with an IC50 of 8.7 μg/mL, demonstrating significant anti-inflammatory properties. Additionally, this compound reduces nitric oxide (NO) production and exhibits notable cytotoxic effects against tumor cells, making it a valuable tool for cancer and inflammation research. -
NF-κB Inhibitor
Sul-121 hydrochloride is a potent NF-κB inhibitor that effectively reduces airway inflammation and hyperresponsiveness in models of chronic obstructive pulmonary disease (COPD). This compound demonstrates a dose-dependent inhibition of lipopolysaccharide-induced airway neutrophilia and attenuates oxidative stress markers in human airway smooth muscle cells. By preventing the nuclear translocation of the NF-κB subunit p65, Sul-121 hydrochloride decreases the release of pro-inflammatory cytokines, making it a valuable tool for investigating inflammatory pathways in respiratory diseases. -
NF-κB Inhibitor
OT-551 is a selective NF-κB inhibitor that exhibits both antioxidant and anti-inflammatory properties. This compound is utilized in research focused on retinal diseases, providing a valuable tool for exploring the mechanisms of inflammation and oxidative stress in these conditions. Its ability to modulate NF-κB signaling pathways positions OT-551 as a promising candidate for therapeutic development in ocular research. -
NF-κB Inhibitor
9,10-Dimethoxycanthin-6-one is an alkaloid compound that functions as an inhibitor of NF-κB. It demonstrates significant inhibitory activity with an IC50 value of 19.5 μM. This compound is primarily utilized in research pertaining to inflammatory responses and cancer pathways, making it relevant for studies investigating NF-κB signaling modulation. -
NF-κB Inhibitor
Teuclatriol is an NF-κB inhibitor derived from Salvia mirzayanii, exhibiting notable anti-inflammatory properties. It effectively inhibits TNF-α secretion in a dose-dependent manner, making it valuable for research involving inflammatory pathways and the modulation of NF-κB activity. This compound is essential for studies focused on chronic inflammation, autoimmune diseases, and related therapeutic developments. -
NF-κB Inhibitor
NF-κB-IN-13 is a selective inhibitor of the NF-κB signaling pathway. This compound effectively suppresses lipopolysaccharide (LPS)-induced NF-κB activation and nitric oxide (NO) production in RAW264.7 macrophages, demonstrating its potential anti-inflammatory properties. NF-κB-IN-13 is valuable for research applications focusing on inflammation, immune response modulation, and potential therapeutic strategies for related diseases. -
NF-κB Inhibitor
APC0576 is an NF-κB inhibitor that effectively disrupts the activation of the NF-κB signaling pathway, demonstrating an IC50 of 1.0 μM for β-galactosidase. This compound significantly inhibits the release of IL-1-induced chemokines, making it a valuable tool for research related to diseases involving pathological endothelial cell activation. Its targeted action allows for the exploration of therapeutic strategies aimed at modulating inflammatory responses. -
NF-κB Inhibitor
CAY10657 is a potent NF-κB inhibitor that effectively downregulates the expression of proinflammatory cytokines, including IL-6, and chemokines such as MCP-1. This compound demonstrates significant anti-inflammatory activity, particularly in the context of meningitis induced by Streptococcus suis. CAY10657 is a valuable tool for researchers investigating inflammation and associated signaling pathways. -
NF-κB Inhibitor
Icariside F2 is a selective NF-κB inhibitor with an IC50 value of 16.25 μM. This aromatic glycoside, extracted from the leaves of E. ulmoides Oliver, exhibits significant anti-inflammatory activity. It is utilized in biomedical research to explore therapeutic strategies for conditions mediated by NF-κB signaling. -
ROR-γ Inhibitor
CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases. -
11β-hydroxysteroid dehydrogenase 1 Inhibitor
Lunularin is a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1, exhibiting an IC50 of 45.44 μM for human and 17.39 μM for rat enzymes. This compound has been shown to modulate gene expression by upregulating Sirt1 and Hmox1 in liver tissue, while also reducing food intake, body weight gain, and blood glucose levels in high-fat diet mice. Furthermore, Lunularin displays anti-cancer properties by inhibiting cell proliferation and colony formation in renal and colon cancer cell lines, along with suppression of LPS-induced NF-κB pathway activation. This reagent is valuable for research in obesity, cancer biology, inflammation, and metabolic disorders. -
ACAT Inhibitor
ACAT-IN-8 is a selective inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT), a key enzyme involved in intracellular cholesterol esterification. By inhibiting ACAT, this compound modulates lipid metabolism and significantly impacts NF-κB mediated transcription. ACAT-IN-8 is useful for research applications related to cardiovascular diseases, metabolic disorders, and inflammation, providing insights into cholesterol-related pathways and their regulation. -
TBK1/IKKε Inhibitor
BAY-985 is a selective ATP-competitive dual inhibitor targeting TBK1 and IKKε, demonstrating high potency with IC50 values of 2 nM for TBK1 under low ATP conditions and 30 nM under high ATP conditions, and 2 nM for IKKε. This inhibitor exhibits significant antitumor activity, making it a valuable tool for research applications focused on cancer therapy and the modulation of inflammatory pathways. Its oral bioavailability further enhances its utility in preclinical studies. -
IKKα Inhibitor
BAY32-5915 is a selective inhibitor of IKKα, exhibiting an IC50 value of 60 nM. This compound effectively prevents the activation of NF-κB without interfering with Doxorubicin-induced pathways. It is valuable for research in inflammation and cancer, providing insights into NF-κB signaling modulation. -
IKK/NF-κB Inhibitor
NF-κB-IN-1 is a selective inhibitor of the IκB kinase (IKK) and functions primarily through the inhibition of NF-κB signaling. This compound effectively blocks the activation of NF-κB, demonstrating potent anti-cancer activity by reducing cell viability in lung cancer cells. Additionally, NF-κB-IN-1 significantly diminishes the clonogenic potential of A549 cells, making it a valuable tool for research on cancer therapeutics targeting NF-κB pathways.
