NF-κB

NF-κB-IN-17 is an NF-κB inhibitor that effectively suppresses TNF-α-induced NF-κB DNA binding activity in C2C12 cells. Its mechanistic action provides valuable insights into the modulation of inflammatory responses, making it a useful tool for research applications focused on immune regulation and cancer biology. This reagent is suitable for studies examining the NF-κB signaling pathway and its implications in various disease models.

Avenanthramide-C methyl ester is an NF-κB inhibitor that exerts anti-inflammatory effects by inhibiting the secretion of pro-inflammatory factors. This compound blocks NF-κB activation through the inhibition of IKK and IκB phosphorylation, as well as by impairing proteasome activity. Avenanthramide-C methyl ester is valuable for research applications focused on inflammation and related signaling pathways.

Coronalolic acid acts as an NF-κB inhibitor, derived from the apical bud of Gardenia sootepenesis Hutch. This compound effectively suppresses TNF-α-induced NF-κB activation and inhibits nitric oxide (NO) production. It serves as a valuable tool for research applications focused on inflammation and immune response modulation.

Myrcene-d6 functions as an NF-κB inhibitor through its deuterium labeling of the natural compound myrcene. With demonstrated efficacy in inhibiting TNFα and NF-κB activity, myrcene exhibits significant anti-invasive properties, mediates cell cycle arrest, and promotes apoptosis in cancer cells. Its biological activities also include robust blood protection and anti-inflammatory effects, making it a valuable reagent for research in cancer biology and inflammatory responses.

NF-κB-IN-9 is a potent inhibitor of nuclear factor kappa B (NF-κB), functioning as a sonosensitizer with an excitation/emission wavelength of 489/628 nm. This compound exhibits significant inhibition of NF-κB signaling pathways, attributed to its dual resveratrol units. NF-κB-IN-9 demonstrates effective anti-tumor activity and exhibits pronounced sonocytotoxicity against various cancer cell lines. Additionally, NF-κB-IN-9 has shown favorable biosafety profiles in xenograft mouse models, making it a valuable tool for cancer research.

Licoagrochalcone C is a flavonoid that serves as an effective inhibitor of NF-κB transcription. It demonstrates significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound is valuable for research applications focused on inflammatory responses and NF-κB-related signaling pathways.

(R)-SEMBL is a potent inhibitor of the NF-κB signaling pathway. This compound exhibits significant biological activity in the modulation of inflammatory responses and has potential applications in cancer research, autoimmune diseases, and metabolic disorders such as diabetes. Additionally, (R)-SEMBL may be useful in investigating therapeutic strategies for cardiovascular diseases and complications associated with defective reperfusion injury.

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene that acts as a nuclear factor kappa B (NF-κB) inhibitor. It effectively inhibits TNFα-triggered NF-κB activity with an IC50 of 8.7 μg/mL, demonstrating significant anti-inflammatory properties. Additionally, this compound reduces nitric oxide (NO) production and exhibits notable cytotoxic effects against tumor cells, making it a valuable tool for cancer and inflammation research.

Sul-121 hydrochloride is a potent NF-κB inhibitor that effectively reduces airway inflammation and hyperresponsiveness in models of chronic obstructive pulmonary disease (COPD). This compound demonstrates a dose-dependent inhibition of lipopolysaccharide-induced airway neutrophilia and attenuates oxidative stress markers in human airway smooth muscle cells. By preventing the nuclear translocation of the NF-κB subunit p65, Sul-121 hydrochloride decreases the release of pro-inflammatory cytokines, making it a valuable tool for investigating inflammatory pathways in respiratory diseases.

OT-551 is a selective NF-κB inhibitor that exhibits both antioxidant and anti-inflammatory properties. This compound is utilized in research focused on retinal diseases, providing a valuable tool for exploring the mechanisms of inflammation and oxidative stress in these conditions. Its ability to modulate NF-κB signaling pathways positions OT-551 as a promising candidate for therapeutic development in ocular research.

9,10-Dimethoxycanthin-6-one is an alkaloid compound that functions as an inhibitor of NF-κB. It demonstrates significant inhibitory activity with an IC50 value of 19.5 μM. This compound is primarily utilized in research pertaining to inflammatory responses and cancer pathways, making it relevant for studies investigating NF-κB signaling modulation.

Teuclatriol is an NF-κB inhibitor derived from Salvia mirzayanii, exhibiting notable anti-inflammatory properties. It effectively inhibits TNF-α secretion in a dose-dependent manner, making it valuable for research involving inflammatory pathways and the modulation of NF-κB activity. This compound is essential for studies focused on chronic inflammation, autoimmune diseases, and related therapeutic developments.

NF-κB-IN-13 is a selective inhibitor of the NF-κB signaling pathway. This compound effectively suppresses lipopolysaccharide (LPS)-induced NF-κB activation and nitric oxide (NO) production in RAW264.7 macrophages, demonstrating its potential anti-inflammatory properties. NF-κB-IN-13 is valuable for research applications focusing on inflammation, immune response modulation, and potential therapeutic strategies for related diseases.

APC0576 is an NF-κB inhibitor that effectively disrupts the activation of the NF-κB signaling pathway, demonstrating an IC50 of 1.0 μM for β-galactosidase. This compound significantly inhibits the release of IL-1-induced chemokines, making it a valuable tool for research related to diseases involving pathological endothelial cell activation. Its targeted action allows for the exploration of therapeutic strategies aimed at modulating inflammatory responses.

CAY10657 is a potent NF-κB inhibitor that effectively downregulates the expression of proinflammatory cytokines, including IL-6, and chemokines such as MCP-1. This compound demonstrates significant anti-inflammatory activity, particularly in the context of meningitis induced by Streptococcus suis. CAY10657 is a valuable tool for researchers investigating inflammation and associated signaling pathways.

Icariside F2 is a selective NF-κB inhibitor with an IC50 value of 16.25 μM. This aromatic glycoside, extracted from the leaves of E. ulmoides Oliver, exhibits significant anti-inflammatory activity. It is utilized in biomedical research to explore therapeutic strategies for conditions mediated by NF-κB signaling.

CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases.

PMX464 is a thiol-reactive quinol that acts as an inhibitor of the thioredoxin-thioredoxin reductase (Trx/TrxR) system. This compound has been shown to inhibit NF-κB-mediated pro-inflammatory activation in human type II alveolar epithelial cells, making it a valuable tool for research focused on inflammation and oxidative stress. PMX464 is particularly useful in studies examining the role of redox signaling in various pathophysiological conditions.

MHY884 is a potent tyrosinase inhibitor that effectively mitigates UVB-induced activation of the NF-κB signaling pathway by downregulating oxidative stress. This compound demonstrates a reduction in oxidative stress within melanoma cells, leading to diminished NF-κB activity in irradiated models. MHY884 holds significant promise for investigations into the mechanisms of UVB-induced skin damage and its potential therapeutic applications.

TML-6 is an orally active curcumin derivative that functions as a β-amyloid (Aβ) inhibitor by impeding the synthesis of β-amyloid precursor protein. It demonstrates key biological activities including the upregulation of Apo E, suppression of NF-κB and mTOR pathways, and enhancement of the anti-oxidative Nrf2 response. TML-6 is positioned as a promising candidate for research in Alzheimer's disease (AD) mechanisms and therapeutic developments.

5-Amino-8-hydroxyquinoline is a non-competitive inhibitor of the 20S proteasome, demonstrating potent inhibitory effects on NF-κB activity. This compound induces apoptosis in cancer cells while exhibiting minimal cytotoxicity towards normal hematopoietic cells. It is valuable for research applications in cancer biology, particularly in the study of leukemia and related malignancies.

DPLG3 is a selective inhibitor of the immunoproteasome β5i subunit, demonstrating an IC50 of 4.5 nM. It effectively inhibits the mouse i-20S proteasome with an IC50 value of 9.4 nM. DPLG3 is capable of downregulating the protein levels of NF-κB p50 and p65, highlighting its potential in the study of immune-related diseases and therapeutic applications.

Biotin-(Oaa)3-epoxomicin is a biotinylated proteasome inhibitor derived from Epoxomicin, connected through three hydrophilic oxaacetyl amino acid linkers. This compound is utilized primarily in proteomic research for the capture and identification of proteasome complexes, facilitating target validation and elucidation of intracellular targets. Epoxomicin effectively inhibits proteasome activity through covalent binding to catalytic subunits such as LMP7, X, MECL1, and Z, with a pronounced effect on chymotrypsin-like activity, while sparing non-proteasomal proteases like trypsin and papain. Additionally, it serves as an NF-κB inhibitor, demonstrating potential in studies of inflammatory responses.

5-Amino-8-hydroxyquinoline dihydrochloride is a potent non-competitive inhibitor of the 20S proteasome. This compound effectively inhibits NF-κB activity, leading to apoptosis in cancer cells while exhibiting minimal cytotoxicity towards normal hematopoietic cells. Its unique properties make it a valuable tool for cancer research, particularly in studies related to leukemia and other malignancies.

Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the proteasome, exhibiting an inhibition constant (Ki) of 460 nM. This compound also functions as an inhibitor of NF-κB nuclear translocation, making it valuable for studies involving immune response and inflammation. Research applications include investigations into proteolytic processes and the role of cytokines in various disease models.

4-Nitrochalcone serves as a proteasome inhibitor, specifically targeting the proteasomal degradation pathway. It effectively inhibits the activity of NF-κB induced by TNFα, making it a valuable tool for studying inflammatory processes and signaling pathways. This compound is utilized in research focused on cancer, neurodegenerative diseases, and other conditions where proteasome activity plays a critical role.

Gabexate mesylate is a competitive proteasome inhibitor, primarily targeting serine proteinases such as thrombin and Factor Xa. It exhibits diverse biological activity, including anticoagulant effects by modulating thrombin activity and anti-inflammatory properties through the inhibition of NF-κB and proinflammatory cytokines. Gabexate mesylate is commonly utilized in research focused on pancreatitis and disseminated intravascular coagulation, making it a valuable reagent for studies in hemostasis and inflammation.

Erdosteine functions as a bacterial inhibitor by inhibiting lipopolysaccharide (LPS)-induced activation of NF-κB. This compound exhibits muco-modulatory, anti-bacterial, anti-inflammatory, and antioxidant properties. Erdosteine is primarily utilized in research applications focused on respiratory disorders and inflammation, supporting the study of therapeutic interventions in these areas.

Isoquercitrin is a potent nitric oxide synthase inhibitor with significant antioxidant and anti-inflammatory properties. This naturally occurring polyphenol exerts protective effects against ethanol-induced hepatotoxicity and oxidative stress, primarily through the activation of the Nrf2/ARE signaling pathway. Additionally, Isoquercitrin modulates the expression of nitric oxide synthase 2 (NOS2) via the nuclear factor-κB (NF-κB) regulatory mechanism. Due to its high bioavailability and low toxicity, Isoquercitrin presents potential applications in research on metabolic disorders and the prevention of birth defects in diabetic pregnancies.

Benzoyloxypaeoniflorin is a potent tyrosinase inhibitor derived from the root of Paeonia suffruticosa, exhibiting an IC50 value of 0.453 mM against mushroom tyrosinase. Additionally, it functions as an NF-κB inhibitor, contributing to enhanced blood circulation by inhibiting platelet aggregation and blood coagulation. This compound is of significant interest in research applications focused on skin disorders and inflammation.

Flaconitine is a potent inhibitor of the NF-κB signaling pathway. This compound has been shown to effectively block the activation of NF-κB, thus modulating inflammatory responses. Flaconitine is widely used in research focused on immunology, cancer biology, and studies involving inflammatory diseases. Its ability to regulate gene expression through NF-κB inhibition makes it a valuable tool for investigating cellular signaling and therapeutic pathways.

Tolterodine is an mAChR inhibitor that competitively binds to acetylcholine, leading to a reduction in sympathetic excitation and inhibition of involuntary bladder muscle contractions. It is known to restore the Nrf2/NF-κB signaling pathway, providing protection against inflammatory responses and ferroptosis. Additionally, Tolterodine mitigates LPS-induced reactive oxygen species production and lipid oxidation, making it valuable for research in urinary tract infections and overactive bladder conditions.

RN-0001 is a potent inhibitor of cyclophilins, specifically demonstrating Ki values of 4.1 nM and 12.0 nM against Cyclophilin A (CypA) and Cyclophilin D (CypD), respectively. By directly binding to CypD, RN-0001 effectively inhibits its peptidyl-prolyl cis-trans isomerase activity, preventing mitochondrial permeability transition pore opening. This compound enhances mitochondrial function, diminishes reactive oxygen species (ROS) production, and downregulates lipogenic marker expression. Additionally, RN-0001 inhibits NF-κB p65 nuclear translocation and reduces the release of activated caspase-3 and cytochrome c, making it a valuable tool for investigating alcohol-associated liver disease.

Rhynchophylline is an alkaloid compound characterized as an NF-κB inhibitor. It exhibits significant biological activity with potential applications in anti-inflammatory and neuroprotective research. This compound is derived from Uncaria rhynchophyllum and is of interest for studies investigating the modulation of inflammatory pathways and neuronal protection mechanisms.