NF-κB

Sootepin D is a triterpene that serves as an NF-κB inhibitor. It effectively suppresses TNF-α-induced NF-κB activity with an IC50 of 8.3 μM, demonstrating significant anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways.

AM-0216 is a potent inhibitor of NF-κB-inducing kinase (NIK), exhibiting a Ki value of 2 nM. This compound selectively modulates NF-κB signaling pathways, making it valuable for investigating NF-κB-dependent hematologic malignancies, such as multiple myeloma, as well as autoimmune disorders. The specificity and efficacy of AM-0216 position it as a significant tool in the study of related therapeutic targets and disease mechanisms.

NF-κB-IN-8 is a selective NF-κB inhibitor that competitively antagonizes lipopolysaccharide (LPS) binding to MD-2. This compound effectively reduces the expression of inflammatory mediators, making it a valuable tool for studying inflammatory responses. Additionally, NF-κB-IN-8 has been shown to inhibit alkaline phosphatase (ALP) activity. It is particularly relevant for research into inflammation-related conditions, such as acute lung injury (ALI).

Ratutrelvir is an NF-κB p65 inhibitor that targets the translocation of NF-κB p65 from the cytoplasm to the nucleus. By reducing phosphorylation levels of NF-κB p65 and IκBα, Ratutrelvir effectively inhibits the DNA-binding activity of NF-κB p65. This compound has been demonstrated to impair migration and invasion capabilities of breast cancer cells, as well as decrease their viability and colony-forming potential, making it a valuable tool for research in luminal A breast cancer.

Laurotetanine is a potent isoquinoline alkaloid functioning as an NF-κB inhibitor. It exhibits anti-asthmatic properties by modulating immune responses, specifically inhibiting IgE and histamine release, alongside reducing inflammatory reactions. Laurotetanine's mechanism involves the downregulation of MUC5AC and NF-κB signaling pathways, making it a valuable tool for research in inflammatory diseases and asthma therapy.

Dauricinoline is a potent orally active inhibitor of NF-κB, effectively blocking NF-κB activation induced by TNF-α. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating inflammatory diseases, particularly in the context of lung inflammation. Researchers may utilize Dauricinoline to explore the mechanisms underlying NF-κB-mediated signaling pathways and their role in various inflammatory conditions.

NIK-IN-1 is a potent inhibitor of NF-κB-inducing kinase (NIK), a critical regulator in the NF-κB signaling pathway. This compound demonstrates significant anti-inflammatory activity and is utilized in research focused on hepatic inflammatory diseases and acute liver injury. Its application helps elucidate the role of NIK in liver pathology and potential therapeutic interventions.

Pterocenoid C is a potent inhibitor of the NF-κB signaling pathway. This compound demonstrates significant biological activity by modulating inflammatory responses and has potential applications in the study of diseases associated with NF-κB dysregulation, including cancer and autoimmune disorders. Pterocenoid C serves as a valuable tool for researchers investigating the intricate roles of NF-κB in various biological processes and disease mechanisms.

mcIRBP-9 is an orally bioavailable NF-κB inhibitor that effectively reduces pro-inflammatory cytokines such as TNF-α, IL-1β, and TGF-β1 in renal tissues. Additionally, mcIRBP-9 decreases LPS-induced production of IL-1β, making it a valuable tool for studying inflammatory processes. This compound is relevant to research focused on diabetic nephropathy and type 2 diabetes mellitus, providing insights into the underlying mechanisms of these conditions.

NF-κB-IN-17 is an NF-κB inhibitor that effectively suppresses TNF-α-induced NF-κB DNA binding activity in C2C12 cells. Its mechanistic action provides valuable insights into the modulation of inflammatory responses, making it a useful tool for research applications focused on immune regulation and cancer biology. This reagent is suitable for studies examining the NF-κB signaling pathway and its implications in various disease models.

Avenanthramide-C methyl ester is an NF-κB inhibitor that exerts anti-inflammatory effects by inhibiting the secretion of pro-inflammatory factors. This compound blocks NF-κB activation through the inhibition of IKK and IκB phosphorylation, as well as by impairing proteasome activity. Avenanthramide-C methyl ester is valuable for research applications focused on inflammation and related signaling pathways.

Coronalolic acid acts as an NF-κB inhibitor, derived from the apical bud of Gardenia sootepenesis Hutch. This compound effectively suppresses TNF-α-induced NF-κB activation and inhibits nitric oxide (NO) production. It serves as a valuable tool for research applications focused on inflammation and immune response modulation.

Myrcene-d6 functions as an NF-κB inhibitor through its deuterium labeling of the natural compound myrcene. With demonstrated efficacy in inhibiting TNFα and NF-κB activity, myrcene exhibits significant anti-invasive properties, mediates cell cycle arrest, and promotes apoptosis in cancer cells. Its biological activities also include robust blood protection and anti-inflammatory effects, making it a valuable reagent for research in cancer biology and inflammatory responses.

NF-κB-IN-9 is a potent inhibitor of nuclear factor kappa B (NF-κB), functioning as a sonosensitizer with an excitation/emission wavelength of 489/628 nm. This compound exhibits significant inhibition of NF-κB signaling pathways, attributed to its dual resveratrol units. NF-κB-IN-9 demonstrates effective anti-tumor activity and exhibits pronounced sonocytotoxicity against various cancer cell lines. Additionally, NF-κB-IN-9 has shown favorable biosafety profiles in xenograft mouse models, making it a valuable tool for cancer research.

Licoagrochalcone C is a flavonoid that serves as an effective inhibitor of NF-κB transcription. It demonstrates significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound is valuable for research applications focused on inflammatory responses and NF-κB-related signaling pathways.

(R)-SEMBL is a potent inhibitor of the NF-κB signaling pathway. This compound exhibits significant biological activity in the modulation of inflammatory responses and has potential applications in cancer research, autoimmune diseases, and metabolic disorders such as diabetes. Additionally, (R)-SEMBL may be useful in investigating therapeutic strategies for cardiovascular diseases and complications associated with defective reperfusion injury.

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene that acts as a nuclear factor kappa B (NF-κB) inhibitor. It effectively inhibits TNFα-triggered NF-κB activity with an IC50 of 8.7 μg/mL, demonstrating significant anti-inflammatory properties. Additionally, this compound reduces nitric oxide (NO) production and exhibits notable cytotoxic effects against tumor cells, making it a valuable tool for cancer and inflammation research.

Sul-121 hydrochloride is a potent NF-κB inhibitor that effectively reduces airway inflammation and hyperresponsiveness in models of chronic obstructive pulmonary disease (COPD). This compound demonstrates a dose-dependent inhibition of lipopolysaccharide-induced airway neutrophilia and attenuates oxidative stress markers in human airway smooth muscle cells. By preventing the nuclear translocation of the NF-κB subunit p65, Sul-121 hydrochloride decreases the release of pro-inflammatory cytokines, making it a valuable tool for investigating inflammatory pathways in respiratory diseases.

OT-551 is a selective NF-κB inhibitor that exhibits both antioxidant and anti-inflammatory properties. This compound is utilized in research focused on retinal diseases, providing a valuable tool for exploring the mechanisms of inflammation and oxidative stress in these conditions. Its ability to modulate NF-κB signaling pathways positions OT-551 as a promising candidate for therapeutic development in ocular research.

9,10-Dimethoxycanthin-6-one is an alkaloid compound that functions as an inhibitor of NF-κB. It demonstrates significant inhibitory activity with an IC50 value of 19.5 μM. This compound is primarily utilized in research pertaining to inflammatory responses and cancer pathways, making it relevant for studies investigating NF-κB signaling modulation.

Teuclatriol is an NF-κB inhibitor derived from Salvia mirzayanii, exhibiting notable anti-inflammatory properties. It effectively inhibits TNF-α secretion in a dose-dependent manner, making it valuable for research involving inflammatory pathways and the modulation of NF-κB activity. This compound is essential for studies focused on chronic inflammation, autoimmune diseases, and related therapeutic developments.

NF-κB-IN-13 is a selective inhibitor of the NF-κB signaling pathway. This compound effectively suppresses lipopolysaccharide (LPS)-induced NF-κB activation and nitric oxide (NO) production in RAW264.7 macrophages, demonstrating its potential anti-inflammatory properties. NF-κB-IN-13 is valuable for research applications focusing on inflammation, immune response modulation, and potential therapeutic strategies for related diseases.

APC0576 is an NF-κB inhibitor that effectively disrupts the activation of the NF-κB signaling pathway, demonstrating an IC50 of 1.0 μM for β-galactosidase. This compound significantly inhibits the release of IL-1-induced chemokines, making it a valuable tool for research related to diseases involving pathological endothelial cell activation. Its targeted action allows for the exploration of therapeutic strategies aimed at modulating inflammatory responses.

CAY10657 is a potent NF-κB inhibitor that effectively downregulates the expression of proinflammatory cytokines, including IL-6, and chemokines such as MCP-1. This compound demonstrates significant anti-inflammatory activity, particularly in the context of meningitis induced by Streptococcus suis. CAY10657 is a valuable tool for researchers investigating inflammation and associated signaling pathways.

Icariside F2 is a selective NF-κB inhibitor with an IC50 value of 16.25 μM. This aromatic glycoside, extracted from the leaves of E. ulmoides Oliver, exhibits significant anti-inflammatory activity. It is utilized in biomedical research to explore therapeutic strategies for conditions mediated by NF-κB signaling.

CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases.

Gabexate mesylate is a competitive proteasome inhibitor, primarily targeting serine proteinases such as thrombin and Factor Xa. It exhibits diverse biological activity, including anticoagulant effects by modulating thrombin activity and anti-inflammatory properties through the inhibition of NF-κB and proinflammatory cytokines. Gabexate mesylate is commonly utilized in research focused on pancreatitis and disseminated intravascular coagulation, making it a valuable reagent for studies in hemostasis and inflammation.

Erdosteine functions as a bacterial inhibitor by inhibiting lipopolysaccharide (LPS)-induced activation of NF-κB. This compound exhibits muco-modulatory, anti-bacterial, anti-inflammatory, and antioxidant properties. Erdosteine is primarily utilized in research applications focused on respiratory disorders and inflammation, supporting the study of therapeutic interventions in these areas.

Isoquercitrin is a potent nitric oxide synthase inhibitor with significant antioxidant and anti-inflammatory properties. This naturally occurring polyphenol exerts protective effects against ethanol-induced hepatotoxicity and oxidative stress, primarily through the activation of the Nrf2/ARE signaling pathway. Additionally, Isoquercitrin modulates the expression of nitric oxide synthase 2 (NOS2) via the nuclear factor-κB (NF-κB) regulatory mechanism. Due to its high bioavailability and low toxicity, Isoquercitrin presents potential applications in research on metabolic disorders and the prevention of birth defects in diabetic pregnancies.

Benzoyloxypaeoniflorin is a potent tyrosinase inhibitor derived from the root of Paeonia suffruticosa, exhibiting an IC50 value of 0.453 mM against mushroom tyrosinase. Additionally, it functions as an NF-κB inhibitor, contributing to enhanced blood circulation by inhibiting platelet aggregation and blood coagulation. This compound is of significant interest in research applications focused on skin disorders and inflammation.

Flaconitine is a potent inhibitor of the NF-κB signaling pathway. This compound has been shown to effectively block the activation of NF-κB, thus modulating inflammatory responses. Flaconitine is widely used in research focused on immunology, cancer biology, and studies involving inflammatory diseases. Its ability to regulate gene expression through NF-κB inhibition makes it a valuable tool for investigating cellular signaling and therapeutic pathways.

Tolterodine is an mAChR inhibitor that competitively binds to acetylcholine, leading to a reduction in sympathetic excitation and inhibition of involuntary bladder muscle contractions. It is known to restore the Nrf2/NF-κB signaling pathway, providing protection against inflammatory responses and ferroptosis. Additionally, Tolterodine mitigates LPS-induced reactive oxygen species production and lipid oxidation, making it valuable for research in urinary tract infections and overactive bladder conditions.

RN-0001 is a potent inhibitor of cyclophilins, specifically demonstrating Ki values of 4.1 nM and 12.0 nM against Cyclophilin A (CypA) and Cyclophilin D (CypD), respectively. By directly binding to CypD, RN-0001 effectively inhibits its peptidyl-prolyl cis-trans isomerase activity, preventing mitochondrial permeability transition pore opening. This compound enhances mitochondrial function, diminishes reactive oxygen species (ROS) production, and downregulates lipogenic marker expression. Additionally, RN-0001 inhibits NF-κB p65 nuclear translocation and reduces the release of activated caspase-3 and cytochrome c, making it a valuable tool for investigating alcohol-associated liver disease.

Rhynchophylline is an alkaloid compound characterized as an NF-κB inhibitor. It exhibits significant biological activity with potential applications in anti-inflammatory and neuroprotective research. This compound is derived from Uncaria rhynchophyllum and is of interest for studies investigating the modulation of inflammatory pathways and neuronal protection mechanisms.