NF449 is a potent antagonist of the P2X1 receptor, demonstrating IC50 values of 0.28 nM for rP2X1, 0.69 nM for rP2X1+5, and 120 nM for P2X2+3. It selectively inhibits Gsα coupling, suppressing GTP[γS] binding to Gsα-s and diminishing adenylyl cyclase activity. This compound is crucial for research applications involving the modulation of purinergic signaling and studies related to cardiovascular and inflammatory conditions.
NF449 is a potent antagonist of the P2X1 receptor, demonstrating IC50 values of 0.28 nM for rP2X1, 0.69 nM for rP2X1+5, and 120 nM for P2X2+3. It selectively inhibits Gsα coupling, suppressing GTP[γS] binding to Gsα-s and diminishing adenylyl cyclase activity. This compound is crucial for research applications involving the modulation of purinergic signaling and studies related to cardiovascular and inflammatory conditions.
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