(-)-Niguldipine hydrochloride is a calcium channel antagonist that inhibits calcium influx across cell membranes, leading to vasodilation. Its biological activity includes the inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, demonstrating a pID50 of 9.93, as well as high affinity for calcium channel binding sites in guinea pig skeletal muscle membranes with a Ki of 8.10. Additionally, (-)-Niguldipine hydrochloride effectively lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55) and has potential applications in treating cardiovascular conditions such as hypertension, angina pectoris, and arrhythmias.
(-)-Niguldipine hydrochloride is a calcium channel antagonist that inhibits calcium influx across cell membranes, leading to vasodilation. Its biological activity includes the inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, demonstrating a pID50 of 9.93, as well as high affinity for calcium channel binding sites in guinea pig skeletal muscle membranes with a Ki of 8.10. Additionally, (-)-Niguldipine hydrochloride effectively lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55) and has potential applications in treating cardiovascular conditions such as hypertension, angina pectoris, and arrhythmias.
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