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Nimustine hydrochloride is an antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine.
| In vitro | DMSO | 60 mg/mL (194.08 mM) | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.35 mL | 161.73 mL | 323.47 mL |
| 0.5 mM | 6.47 mL | 32.35 mL | 64.69 mL |
| 1 mM | 3.23 mL | 16.17 mL | 32.35 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
*The above data is based on the productmolecular weight 309.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17583 |
|---|---|
| CAS No. | 55661-38-6 |
| Formula | C9H14Cl2N6O2 |
| M. Wt | 309.15 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | CS 439 HCl; CS439 HCl; CS-439 HCl; CS-439; CS439; CS 439 |
| SMILES | O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O.[H]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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