NRX-103094 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of phospho-Ser33/Ser37 β-catenin to its E3 ligase, SCFβ-TrCP. With an EC50 of 62 nM and a Kd of 0.6 nM, NRX-103094 facilitates this critical protein-protein interaction, making it a valuable tool for research into Wnt signaling pathways and related cellular processes. Its ability to modulate β-catenin stability can aid investigations into various aspects of cellular biology, including cancer research and developmental biology.
NRX-103094 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of phospho-Ser33/Ser37 β-catenin to its E3 ligase, SCFβ-TrCP. With an EC50 of 62 nM and a Kd of 0.6 nM, NRX-103094 facilitates this critical protein-protein interaction, making it a valuable tool for research into Wnt signaling pathways and related cellular processes. Its ability to modulate β-catenin stability can aid investigations into various aspects of cellular biology, including cancer research and developmental biology.
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