NRX-252114 is a potent enhancer of the β-catenin:β-TrCP interaction, facilitating the binding of phosphorylated β-catenin peptides to the E3 ubiquitin ligase SCFβ-TrCP. With an EC50 of 6.5 nM and a Kd of 0.4 nM, this compound significantly boosts the degradation of mutant β-catenin. NRX-252114 is useful in research applications focused on the Wnt signaling pathway and its implications in cancer biology and developmental processes.
NRX-252114 is a potent enhancer of the β-catenin:β-TrCP interaction, facilitating the binding of phosphorylated β-catenin peptides to the E3 ubiquitin ligase SCFβ-TrCP. With an EC50 of 6.5 nM and a Kd of 0.4 nM, this compound significantly boosts the degradation of mutant β-catenin. NRX-252114 is useful in research applications focused on the Wnt signaling pathway and its implications in cancer biology and developmental processes.
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