NS-018 maleate

Catalog No.: A16226

JAK2 inhibitor

NS-018 maleate Chemical Structure

CAS NO. 1354799-87-3

NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470nM in Ba/F3-JAK2V617F cells . have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2.

Availability: In stock

Package Price Qty
1 mg
$120.00
5 mg
$320.00
10 mg
$460.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470nM in Ba/F3-JAK2V617F cells . have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.91 mL 197.82 mL
0.5 mM 3.96 mL 19.78 mL 39.56 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 505.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16226
Actions Inhibitor
M. Wt 505.5
Formula C25H24FN7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1354799-87-3
Synonyms NS018 maleate, NS 018 maleate
SMILES CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C.C(=CC(=O)O)C(=O)O

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