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JAK2 inhibitor

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Catalog No. A16224

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NS-018 5mg A16224-5
NS-018 10mg A16224-10
NS-018 50mg A16224-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NS-018 is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity.


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Chemical Information

Catalog Num A16224
Actions Inhibitor
M. Wt 389.43
Formula C21H20FN7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1239358-86-1
Synonyms NS018, NS 018
SMILES code CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C
Chemical Name 6-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine

Biological Activity

NS-018 is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.68 mL 128.39 mL 256.79mL
0.5 mM 5.14 mL 25.68 mL 51.36 mL
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL

*The above data is based on the productmolecular weight 389.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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