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$0.00 - Anurag Rathore, .et al. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models, Sci Rep, 2020, 10: 5350 PMID: 32210344
Biological Activity
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
Targets
| USP14 | UCHL5 | |||
| N/A | 2.1 μM |
| In vitro (25°C) | DMSO | Warmed: 42 mg/mL (100.14 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+corn oil | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.84 mL | 119.22 mL | 238.44 mL |
| 0.5 mM | 4.77 mL | 23.84 mL | 47.69 mL |
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
*The above data is based on the productmolecular weight 419.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15391 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1009817-63-3 |
| Formula | C22H17N3O6 |
| M. Wt | 419.39 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | b-AP15 |
| SMILES | C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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