b-AP15 (NSC 687852)

Catalog No.: A15391

DUB inhibitor

b-AP15 (NSC 687852)

b-AP15 (NSC 687852) Chemical Structure

CAS NO. 1009817-63-3

NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.

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10 mg
$55.00
25 mg
$90.00
50 mg
$135.00
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  • Anurag Rathore, .et al. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models, Sci Rep, 2020, 10: 5350 PMID: 32210344

Biological Activity

NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
Targets
USP14 UCHL5
N/A2.1 μM
In vitro (25°C) DMSO Warmed: 42 mg/mL (100.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.84 mL 119.22 mL 238.44 mL
0.5 mM 4.77 mL 23.84 mL 47.69 mL
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15391
Actions Inhibitor
CAS No. 1009817-63-3
Formula C22H17N3O6
M. Wt 419.39
Solubility DMSO
Purity >98%
Synonyms b-AP15
SMILES C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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