OES2-0017 is an antibiotic agent that targets spermine/spermidine acetyltransferase (SpeG) with an IC50 of 34.82 μM. This compound exhibits significant activity in inhibiting growth through low micromolar concentrations, demonstrating potent synergy with polyamines. At elevated concentrations, OES2-0017 disrupts bacterial membrane integrity, making it a valuable reagent for investigating bacterial growth inhibition mechanisms and polyamine metabolism in microbial research.
OES2-0017 is an antibiotic agent that targets spermine/spermidine acetyltransferase (SpeG) with an IC50 of 34.82 μM. This compound exhibits significant activity in inhibiting growth through low micromolar concentrations, demonstrating potent synergy with polyamines. At elevated concentrations, OES2-0017 disrupts bacterial membrane integrity, making it a valuable reagent for investigating bacterial growth inhibition mechanisms and polyamine metabolism in microbial research.
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