Catalog No.
Product Name
Application
Product Information
Citations
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impurity of Calcitriol
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). -
Impurity
Gefitinib impurity 2 is an impurity of the EGFR tyrosine kinase inhibitor, Gefitinib. While Gefitinib exhibits potent and selective inhibition of EGFR with an IC50 of 33 nM, this impurity may be relevant for studies focused on the characterization and validation of Gefitinib-related compounds. Research applications primarily include analytical chemistry and quality control in the synthesis of Gefitinib. Additionally, the impurity may provide insights into the pharmacological behavior and metabolic pathway analysis of EGFR inhibitors. -
Olanzapine Impurity
Olanzapine ketolactam is an impurity associated with Olanzapine, a selectively acting monoaminergic antagonist. This compound may be utilized in chemical research to study the structural and functional properties of Olanzapine and its metabolites. Its presence could provide insights into the pharmacological profiles and safety assessments of olanzapine formulations. -
Drug Impurity
Methotrexate impurity 4 is a known impurity associated with Methotrexate, primarily classified as a drug impurity. This compound is utilized in research to assess drug purity and stability, as well as to study potential side effects and metabolic pathways related to Methotrexate. Its characterization is critical for quality control and regulatory compliance in pharmaceutical formulations. -
Cetirizine Impurity
Cetirizine methyl ester is a known impurity of Cetirizine, a second-generation antihistamine that functions as a selective, orally active, and long-lasting antagonist of the histamine H1 receptor. This compound serves as an important analytical reference for the study of Cetirizine's purity and quality control processes. Its relevance in biochemical research and pharmaceutical development makes it a valuable tool for investigating the pharmacological profile of antihistamines. -
Impurity of Hydroxychloroquine
Hydroxychloroquine Impurity E is a chemical impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. Hydroxychloroquine is known to inhibit Toll-like receptor 7/9 (TLR7/9) signaling and has demonstrated efficacy in reducing SARS-CoV-2 infection in vitro. This impurity may be useful for studies investigating the purity and activity of Hydroxychloroquine in various biological contexts. -
Iimpurity of Lenvatinib
Lenvatinib N-oxide is a significant impurity of Lenvatinib, a multi-targeted tyrosine kinase inhibitor known for its oral bioactivity. This compound serves as an important reference standard in pharmacological studies, aiding the characterization and quality control of Lenvatinib. Researchers may utilize Lenvatinib N-oxide for analytical purposes to assess the purity and stability of Lenvatinib formulations in various biological research contexts. -
Linagliptin Impurity
Linagliptin methyldimer is a known impurity of Linagliptin, a potent Dipeptidyl Peptidase IV (DPP-IV) inhibitor that exhibits an IC50 of approximately 1 nM. This compound is utilized primarily in analytical studies to characterize and quantify impurities in Linagliptin formulations. Its presence and behavior are essential for understanding the purity and efficacy of DPP-IV-related therapies in diabetes research. -
Impurity of Sildenafil
Desethyl Sildenafil is an impurity of Sildenafil, primarily known as a potent phosphodiesterase type 5 (PDE5) inhibitor, with an IC50 value of 5.22 nM. It serves as an important reference standard in the analysis of Sildenafil formulations and is utilized in the investigation of PDE5 inhibition. Research applications include quality control and pharmacokinetic studies related to Sildenafil. -
Drug Impurity
Ramipril diketopiperazine is a chemical impurity associated with the ACE inhibitor Ramipril. It is important for analytical studies and quality control in pharmaceutical research, particularly in the evaluation of drug formulation and stability. The presence of this impurity can influence the pharmacokinetics and safety profile of Ramipril, making it crucial for researchers analyzing drug metabolism and efficacy. -
Ramiprilat Impurity
Ramiprilat diketopiperazine, also known as Impurity K of Ramiprilat, serves as a significant impurity within the context of pharmaceutical research. Ramiprilat, an active metabolite of Ramipril, functions primarily as a potent angiotensin-converting enzyme (ACE) inhibitor. This compound is important for studying the effects and stability of Ramiprilat in various formulations and can be useful in analytical chemistry to ensure the purity of ACE inhibitors in development. -
Acetaminophen Impurity
4-Acetamidophenyl acetate is identified as an impurity of Acetaminophen and serves as an intermediate in its synthesis. Acetaminophen is known for its selective inhibition of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM, along with notable activity as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). This reagent is valuable for research applications focused on analgesic and anti-inflammatory drug development. -
Ziprasidone Impurity
Keto Ziprasidone is a known impurity of the antipsychotic agent Ziprasidone, which functions primarily as a combined antagonist of serotonin (5-HT) and dopamine receptors. This compound is crucial for research applications focusing on drug metabolism and pharmacokinetics, particularly in understanding the potential effects of impurities on therapeutic efficacy and safety profiles. Its analysis can aid in the development of quality control measures in pharmaceutical formulations. -
Ziprasidone Impurity
Hydroxy ziprasidone is a known impurity of the antipsychotic agent ziprasidone, which functions primarily as a combined antagonist of both serotonin (5-HT) and dopamine receptors. This compound is useful for researchers studying the pharmacological properties and metabolic pathways of ziprasidone, as well as for quality control in the synthesis of pharmaceutical formulations. Its presence can provide insights into the drug's safety, efficacy, and potential side effects. -
Methotrexate Impurity
Methotrexate γ-Methyl Ester is an impurity of the folate antagonist Methotrexate, specifically identified as Methotrexate 5-methyl ester. This compound is utilized in chemical research to study the properties and potential effects of Methotrexate derivatives. It serves as a valuable tool for understanding the metabolism and biochemical activity of folate-related compounds in various biological systems. -
Impurity of Palbociclib
1,1-Dimethylethyl 4-(4-amino-3-pyridinyl)-1-piperazinecarboxylate is identified as an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound aids in the quality assessment of Palbociclib by providing insights into the synthesis and purification processes. Its analysis is crucial for ensuring the integrity and efficacy of CDK inhibition studies, primarily focusing on cell cycle regulation and cancer research applications. -
Impurity of Palbociclib
1,1-Dimethylethyl 4-(5-amino-3-pyridinyl)-1-piperazinecarboxylate is an identified impurity of Palbociclib, an orally administered selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). Palbociclib demonstrates potent biological activity with IC50 values of 11 nM and 16 nM for CDK4 and CDK6, respectively. This reagent can be utilized in research to analyze the purity of Palbociclib and assess its pharmacological properties in cancer studies. -
Ivermectin Impurity
2,3-Dehydro-3,4-dihydro ivermectin is an impurity of ivermectin, primarily exhibiting anthelmintic properties. It demonstrates anti-parasitic activity against Leishmania amazonensis promastigotes and amastigotes, with IC50 values of 13.8 µM and 3.6 µM, respectively. Importantly, this compound does not induce cytotoxicity in macrophages, with an IC50 of 65.5 µM, making it suitable for studies in parasitology and drug development research. -
Oseltamivir Impurity
Oseltamivir-acetate is an impurity associated with Oseltamivir, a well-known neuraminidase inhibitor utilized in the treatment and prevention of influenza A and B. This compound is valuable for research applications involving the analysis of Oseltamivir's purity and the study of its pharmacological properties in antiviral therapies. Understanding the presence of impurities like Oseltamivir-acetate can aid in the development of more effective influenza treatments and enhance the overall quality of the drug formulation. -
Sofosbuvir Impurity
Sofosbuvir impurity G is a diastereoisomeric impurity of Sofosbuvir, which is a potent inhibitor of HCV RNA replication. This compound serves as an important reference standard for quality control and analytical purposes in the research and development of hepatitic C virus treatments. Its characterization is essential for understanding the processing and stability of Sofosbuvir formulations. -
Impurity of Lovastatin
Keto lovastatin is an impurity of Lovastatin that acts as an HMG-CoA reductase inhibitor. This compound exhibits antibacterial activity and is primarily utilized for research related to cholesterol synthesis and metabolic pathways. It serves as a crucial reference material in studies focused on Lovastatin and its derivatives, enhancing understanding of their pharmacological profiles. -
Clindamycin Impurity
Clindamycin 2,4-diphosphate is an impurity associated with Clindamycin phosphate, which is a prodrug of Clindamycin. Clindamycin phosphate functions by inhibiting protein synthesis through its interaction with the bacterial ribosomal 50S subunit. This compound is relevant for studies focused on antibiotic mechanisms, bacterial resistance, and the pharmacological characterization of clindamycin derivatives. -
Olmesartan Impurity
Olmesartan impurity is a byproduct of olmesartan, an angiotensin II receptor (AT1R) antagonist. This reagent is important for quality control and analytical studies of olmesartan in pharmaceutical formulations. Additionally, it can be utilized in research related to hypertension treatment and cardiovascular disease studies, helping to elucidate the functional properties of olmesartan and its impurities. -
Impurity of DM1
DM1 Impurity is a byproduct associated with the synthesis of Mertansine (DM1), a potent linker drug used in antibody-drug conjugates. This impurity is critical for analytical purposes, enabling researchers to assess the purity and stability of Mertansine formulations. Its identification and quantification are essential in ensuring the quality control of therapeutic agents that utilize DM1 in clinical applications. -
Aceclofenac Impurity
Aceclofenac ethyl ester is an impurity of the non-steroidal anti-inflammatory drug Aceclofenac, primarily acting through inhibition of cyclooxygenase (COX) enzymes. This compound may serve as a reference standard in pharmacokinetic studies and method development for analyzing Aceclofenac and its related substances. Its characterization contributes to the understanding of the drug's stability and metabolism, aiding in the overall evaluation of therapeutic efficacy and safety profiles. -
Exenatide Impurity
(D-Asn28)-Exenatide is an impurity of Exenatide, which functions as a long-acting agonist of the glucagon-like peptide-1 receptor. This compound may be used in research applications focusing on peptide synthesis, quality control, and pharmacological studies involving GLP-1 receptor pathways. Its significance lies in understanding the properties and effects of Exenatide-related compounds. -
Budesonide Impurity
Budesonide impurity C is a known impurity associated with Budesonide, a potent inhaled corticosteroid that acts as an agonist of the glucocorticoid receptor. This impurity may play a role in studying the pharmacological profiles and quality control of Budesonide formulations. It is relevant for research applications involving drug stability, metabolism, and the assessment of therapeutic efficacy in inflammatory conditions. -
Prednisolone Impurity
Prednisolone valerate acetate is a known impurity of Prednisolone, a potent, orally active corticosteroid that primarily functions as a glucocorticoid. This compound is relevant for research focused on corticosteroid metabolism and any potential side effects associated with glucocorticoid therapies. Its presence may be significant in the analysis of pharmaceutical formulations containing Prednisolone and supports studies investigating corticosteroid-related biological activity. -
Impurity
6-Iododiosmin is a known impurity of Diosmin, serving as a reference standard for the characterization of Diosmin-related compounds. It is essential for quality control in pharmaceutical formulations and research involving Diosmin's therapeutic applications. This compound aids in the investigation of the chemical behavior and biological properties of Diosmin, thereby enhancing the understanding of its efficacy and safety profiles. -
Ibuprofen Impurity
p-Ethylhydratropic acid is identified as a notable impurity found in ibuprofen, which functions as a potent and selective inhibitor of cyclooxygenase-1 (COX-1). Its presence in pharmaceutical formulations is significant for quality control and analytical studies. Research applications may include the characterization of ibuprofen derivatives and the investigation of their respective pharmacological profiles. -
Impurity
11β-Misoprostol is an impurity derived from the synthesis of Misoprostol, a 15-deoxy-16-hydroxy-16-methyl analog of prostaglandin E1 (PGE1). Its structural characteristics may be important in assessing the quality and purity of Misoprostol preparations. Researchers may utilize 11β-Misoprostol in analytical studies focused on impurity profiling and quality control within pharmaceutical formulations. -
Impurity
Isopropyl 5-(diphenylphosphoryl)pentanoate is an impurity associated with Latanoprost, a prostaglandin analog used in the treatment of glaucoma. This compound serves as a reference material for assessing the purity and quality of Latanoprost formulations. Its presence and characterization are critical for regulatory compliance and ensuring product safety in pharmaceutical research and development. -
Clopidogrel Impurity
Clopidogrel-related Compound B hydrochloride is an impurity of Clopidogrel, functioning as a pharmacological marker in analytical applications. Its presence is an important consideration in the assessment of Clopidogrel purity and efficacy. This compound is primarily utilized in pharmaceutical research to ensure the quality and consistency of Clopidogrel formulations. -
Impurity of Darifenacin
(±)-Darifenacin N-Oxide is an impurity of the selective M3 muscarinic receptor antagonist Darifenacin. This compound may serve as a reference standard in analytical chemistry and pharmacological studies involving Darifenacin. Its characterization is crucial for ensuring the purity and efficacy of Darifenacin in various research applications. -
Exenatide Impurity
(Des-Gly2)-Exenatide is a structural variant of Exenatide, acting as an impurity in this peptide-based drug. Its presence is significant for quality control and purity assessment in pharmaceutical formulations. Researchers utilize this compound to study the stability and degradation pathways of Exenatide, enhancing analytical methods within peptide characterization and drug development processes. -
Atorvastatin Impurity
O-Methyl Atorvastatin calcium serves as an impurity of Atorvastatin, a well-established 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This compound is primarily utilized in research to study the metabolic effects of HMG-CoA inhibitors and their role in lipid regulation. Its biological activity includes the effective reduction of cholesterol levels, making it significant for investigations into cardiovascular disease and dyslipidemia. -
Imatinib Impurity
Imatinib Impurity E is a specific impurity associated with the tyrosine kinase inhibitor Imatinib. Imatinib selectively targets BCR/ABL, PDGFR, and c-Kit kinases, inhibiting their activity by binding near the ATP binding site, thereby stabilizing a closed conformation and reducing enzyme activity. This compound is significant in research focused on cancer treatments and has also demonstrated inhibitory effects against viruses such as SARS-CoV and MERS-CoV. -
Impurity of Atorvastatin
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin, a potent HMG-CoA reductase inhibitor. This compound demonstrates the capacity to effectively lower blood lipid levels and has been shown to inhibit human smooth muscle cell proliferation and invasion with IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a valuable reference for studies involving atorvastatin's pharmacological properties and mechanisms of action. -
Atorvastatin Impurity
Desfluoro-atorvastatin is an impurity of Atorvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This compound is primarily used in the evaluation and characterization of Atorvastatin's purity in pharmaceutical formulations. Its relevance in lipid-lowering research underscores the importance of monitoring impurities that may influence therapeutic efficacy and safety. -
Febuxostat Impurity
Febuxostat impurity 6 is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This impurity is relevant for analytical studies and quality control during the synthesis of Febuxostat. Researchers may utilize Febuxostat impurity 6 to assess the purity of pharmaceutical formulations and investigate potential side effects linked to impurities in drug development. -
Drug Impurity
Quetiapine impurity 4 is a dimeric impurity associated with quetiapine. This compound is primarily investigated for its relevance in the analysis of the purity of quetiapine formulations. It serves as a useful reference standard for quality control and regulatory compliance in pharmaceutical research, particularly in studies assessing the safety and efficacy of antipsychotic medications. -
Glyphosate Impurity
N-Nitrosoglyphosate sodium is a nitrosamine degradation product and synthetic impurity of glyphosate, primarily targeting the glyphosate molecule. This compound is significant for researchers studying the safety and environmental impact of glyphosate herbicides, as it aids in understanding degradation pathways and potential toxicological effects. Its analysis is crucial for regulatory compliance and assessing impurity levels in glyphosate formulations. -
Atorvastatin Impurity
Atorvastatin acetonide is a known impurity of Atorvastatin, derived from patent WO2011131605A1, Compound 4. Atorvastatin functions primarily as an HMG-CoA reductase inhibitor, demonstrating significant efficacy in lowering blood lipid levels. This compound is useful for research applications focused on lipid metabolism and the evaluation of atorvastatin's synthetic pathways and purity. -
Pemetrexed Impurity
N-Methyl pemetrexed is a notable impurity of Pemetrexed, an antifolate cytotoxic agent. This compound exhibits key biological activity by inhibiting folate-dependent enzymes, making it relevant in cancer research. Its study aids in understanding the pharmacological properties and safety profiles of Pemetrexed in therapeutic applications against various malignancies. -
Ivabradine Impurity
Ivabradine impurity 2 is a known impurity of Ivabradine, a selective blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound serves as a valuable reference standard for evaluating the purity and quality of Ivabradine formulations. Its characterization is essential for research applications in pharmacology and quality control in pharmaceutical development, particularly in studies related to cardiac function and rhythm management. -
Atorvastatin Impurity
Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, a potent HMG-CoA reductase inhibitor. This impurity may serve as a useful reference standard in quality control and analytical studies, particularly in assessing the integrity of Atorvastatin formulations. Its identification and quantification can provide insights into the stability and degradation pathways of statin compounds in pharmaceutical research. -
Candesartan Cilexetil Impurity
1H-1-Ethyl Candesartan Cilexetil is an impurity associated with the synthesis of Candesartan Cilexetil, an angiotensin II receptor antagonist. This compound may serve as a critical reference standard in the quality control of pharmaceutical formulations containing Candesartan Cilexetil. Its presence and characterization are essential for ensuring the safety and efficacy of products within the cardiovascular therapeutic landscape. -
Captopril Impurity
Captopril EP Impurity E is a known impurity of the antihypertensive agent Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM. It serves as a valuable reference standard for analytical applications, including quality control and characterization of Captopril formulations. This reagent is essential for studies focusing on the synthesis, stability, and impurity profile of Captopril and its derivatives in pharmaceutical research. -
Captopril Impurity
Captopril EP Impurity B is an impurity associated with Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor. Captopril is utilized primarily as an antihypertensive agent, exhibiting a potent inhibitory activity with an IC50 of 0.025 μM. This impurity may be relevant in pharmacokinetic studies and impurity profiling in the development and quality control of Captopril formulations. -
Impurity
Zopiclone impurity-1 is a byproduct and degradation product associated with the synthesis of zopiclone. This compound is used primarily in analytical and quality control studies to ensure the purity and integrity of zopiclone formulations. Its identification and quantification can aid in understanding degradation pathways and improving manufacturing processes in pharmaceutical development.
