Catalog No.
Product Name
Application
Product Information
Citations
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Impurity of Cetirizine 3-chloro
Cetirizine 3-chloro impurity is a structural variant of Cetirizine 3-chloro, primarily analyzed for its potential effects on pharmacological activity. As an impurity, it is relevant in various quality control and analytical chemistry applications when assessing the purity of Cetirizine formulations. The characterization of this impurity is essential for ensuring the safety and efficacy of related pharmaceutical products. -
Atorvastatin Impurity
3-Oxo Atorvastatin is an impurity of atorvastatin, which acts as an HMG-CoA reductase inhibitor. This compound is critical in studying the metabolic pathways associated with cholesterol synthesis and lipid regulation. Its role as an impurity is essential for accurately assessing the purity and efficacy of atorvastatin in pharmaceutical formulations and research applications. -
Remdesivir Impurity
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of the antiviral agent Remdesivir, a nucleoside analogue primarily targeting viral RNA synthesis. This compound is relevant in assessing the purity and efficacy of Remdesivir, which has demonstrated potent antiviral activity against SARS-CoV and MERS-CoV, with EC50 values of 74 nM in human airway epithelial cells and 30 nM against murine hepatitis virus in delayed brain tumor cells. Research involving this impurity can aid in the development and validation of antiviral therapeutics, particularly in the context of COVID-19. -
Gefitinib Impurity
Gefitinib impurity 1 is a known impurity associated with the tyrosine kinase inhibitor gefitinib, which specifically targets the epidermal growth factor receptor (EGFR). This compound plays a role in research applications aimed at understanding gefitinib's mechanism of action and its effects on EGF-stimulated tumor cell proliferation. Gefitinib demonstrates a potent inhibitory effect on EGFR autophosphorylation and tumor cell growth, making it valuable for studies related to cancer therapeutics and the exploration of resistance mechanisms in oncological research. -
Macamide Impurity
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a known impurity of Macamide, primarily utilized in the study of lipid metabolism and signaling pathways. This compound can be valuable for researchers investigating the biological effects of macamide derivatives and their potential role in modulating cellular processes. Its distinct chemical structure allows for the exploration of its impacts on various biological systems. -
Drug Impurity
Clozapine impurity 3 is a known impurity associated with the antipsychotic agent Clozapine. It serves as a critical reference material for assessing the purity and quality of Clozapine formulations. This reagent is essential for research and analytical applications focused on drug development, impurity profiling, and safety assessments of pharmaceutical compounds. -
Cetilistat Impurity
Cetilistat impurity 1 is a known impurity of the anti-obesity agent Cetilistat, which inhibits pancreatic lipase. This compound demonstrates significant biological activity, inhibiting both rat and human pancreatic lipase with IC50 values of 54.8 nM and 5.95 nM, respectively. It is primarily utilized in research to assess the purity and efficacy of Cetilistat and related formulations in obesity-related studies. -
Daclatasvir Impurity
Daclatasvir Impurity B is an impurity of the antiviral agent Daclatasvir, which targets the HCV NS5A protein. This compound is significant for quality control and analytical purposes in the synthesis and formulation of Daclatasvir. It may also be utilized in research applications aimed at understanding the pharmacological properties and stability of Daclatasvir. -
Impurity of DM1
DM1 Impurity is a byproduct associated with the synthesis of Mertansine (DM1), a potent linker drug used in antibody-drug conjugates. This impurity is critical for analytical purposes, enabling researchers to assess the purity and stability of Mertansine formulations. Its identification and quantification are essential in ensuring the quality control of therapeutic agents that utilize DM1 in clinical applications. -
Ibuprofen Impurity
p-Ethylhydratropic acid is identified as a notable impurity found in ibuprofen, which functions as a potent and selective inhibitor of cyclooxygenase-1 (COX-1). Its presence in pharmaceutical formulations is significant for quality control and analytical studies. Research applications may include the characterization of ibuprofen derivatives and the investigation of their respective pharmacological profiles. -
Impurity
11β-Misoprostol is an impurity derived from the synthesis of Misoprostol, a 15-deoxy-16-hydroxy-16-methyl analog of prostaglandin E1 (PGE1). Its structural characteristics may be important in assessing the quality and purity of Misoprostol preparations. Researchers may utilize 11β-Misoprostol in analytical studies focused on impurity profiling and quality control within pharmaceutical formulations. -
Impurity
Isopropyl 5-(diphenylphosphoryl)pentanoate is an impurity associated with Latanoprost, a prostaglandin analog used in the treatment of glaucoma. This compound serves as a reference material for assessing the purity and quality of Latanoprost formulations. Its presence and characterization are critical for regulatory compliance and ensuring product safety in pharmaceutical research and development. -
Exenatide Impurity
(Des-Gly2)-Exenatide is a structural variant of Exenatide, acting as an impurity in this peptide-based drug. Its presence is significant for quality control and purity assessment in pharmaceutical formulations. Researchers utilize this compound to study the stability and degradation pathways of Exenatide, enhancing analytical methods within peptide characterization and drug development processes. -
Atorvastatin Impurity
O-Methyl Atorvastatin calcium serves as an impurity of Atorvastatin, a well-established 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This compound is primarily utilized in research to study the metabolic effects of HMG-CoA inhibitors and their role in lipid regulation. Its biological activity includes the effective reduction of cholesterol levels, making it significant for investigations into cardiovascular disease and dyslipidemia. -
Imatinib Impurity
Imatinib Impurity E is a specific impurity associated with the tyrosine kinase inhibitor Imatinib. Imatinib selectively targets BCR/ABL, PDGFR, and c-Kit kinases, inhibiting their activity by binding near the ATP binding site, thereby stabilizing a closed conformation and reducing enzyme activity. This compound is significant in research focused on cancer treatments and has also demonstrated inhibitory effects against viruses such as SARS-CoV and MERS-CoV. -
Impurity of Atorvastatin
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin, a potent HMG-CoA reductase inhibitor. This compound demonstrates the capacity to effectively lower blood lipid levels and has been shown to inhibit human smooth muscle cell proliferation and invasion with IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a valuable reference for studies involving atorvastatin's pharmacological properties and mechanisms of action. -
Atorvastatin Impurity
Desfluoro-atorvastatin is an impurity of Atorvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This compound is primarily used in the evaluation and characterization of Atorvastatin's purity in pharmaceutical formulations. Its relevance in lipid-lowering research underscores the importance of monitoring impurities that may influence therapeutic efficacy and safety. -
Febuxostat Impurity
Febuxostat impurity 6 is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This impurity is relevant for analytical studies and quality control during the synthesis of Febuxostat. Researchers may utilize Febuxostat impurity 6 to assess the purity of pharmaceutical formulations and investigate potential side effects linked to impurities in drug development. -
Drug Impurity
Quetiapine impurity 4 is a dimeric impurity associated with quetiapine. This compound is primarily investigated for its relevance in the analysis of the purity of quetiapine formulations. It serves as a useful reference standard for quality control and regulatory compliance in pharmaceutical research, particularly in studies assessing the safety and efficacy of antipsychotic medications. -
Glyphosate Impurity
N-Nitrosoglyphosate sodium is a nitrosamine degradation product and synthetic impurity of glyphosate, primarily targeting the glyphosate molecule. This compound is significant for researchers studying the safety and environmental impact of glyphosate herbicides, as it aids in understanding degradation pathways and potential toxicological effects. Its analysis is crucial for regulatory compliance and assessing impurity levels in glyphosate formulations. -
Atorvastatin Impurity
Atorvastatin acetonide is a known impurity of Atorvastatin, derived from patent WO2011131605A1, Compound 4. Atorvastatin functions primarily as an HMG-CoA reductase inhibitor, demonstrating significant efficacy in lowering blood lipid levels. This compound is useful for research applications focused on lipid metabolism and the evaluation of atorvastatin's synthetic pathways and purity. -
Pemetrexed Impurity
N-Methyl pemetrexed is a notable impurity of Pemetrexed, an antifolate cytotoxic agent. This compound exhibits key biological activity by inhibiting folate-dependent enzymes, making it relevant in cancer research. Its study aids in understanding the pharmacological properties and safety profiles of Pemetrexed in therapeutic applications against various malignancies. -
Ivabradine Impurity
Ivabradine impurity 2 is a known impurity of Ivabradine, a selective blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound serves as a valuable reference standard for evaluating the purity and quality of Ivabradine formulations. Its characterization is essential for research applications in pharmacology and quality control in pharmaceutical development, particularly in studies related to cardiac function and rhythm management. -
Atorvastatin Impurity
Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, a potent HMG-CoA reductase inhibitor. This impurity may serve as a useful reference standard in quality control and analytical studies, particularly in assessing the integrity of Atorvastatin formulations. Its identification and quantification can provide insights into the stability and degradation pathways of statin compounds in pharmaceutical research. -
Candesartan Cilexetil Impurity
1H-1-Ethyl Candesartan Cilexetil is an impurity associated with the synthesis of Candesartan Cilexetil, an angiotensin II receptor antagonist. This compound may serve as a critical reference standard in the quality control of pharmaceutical formulations containing Candesartan Cilexetil. Its presence and characterization are essential for ensuring the safety and efficacy of products within the cardiovascular therapeutic landscape. -
Captopril Impurity
Captopril EP Impurity E is a known impurity of the antihypertensive agent Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM. It serves as a valuable reference standard for analytical applications, including quality control and characterization of Captopril formulations. This reagent is essential for studies focusing on the synthesis, stability, and impurity profile of Captopril and its derivatives in pharmaceutical research. -
Captopril Impurity
Captopril EP Impurity B is an impurity associated with Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor. Captopril is utilized primarily as an antihypertensive agent, exhibiting a potent inhibitory activity with an IC50 of 0.025 μM. This impurity may be relevant in pharmacokinetic studies and impurity profiling in the development and quality control of Captopril formulations. -
Impurity
Zopiclone impurity-1 is a byproduct and degradation product associated with the synthesis of zopiclone. This compound is used primarily in analytical and quality control studies to ensure the purity and integrity of zopiclone formulations. Its identification and quantification can aid in understanding degradation pathways and improving manufacturing processes in pharmaceutical development. -
Captopril Impurity
Captopril EP Impurity C is a known impurity of the antihypertensive agent Captopril, a competitive angiotensin-converting enzyme (ACE) inhibitor. This compound is characterized by its thiol-containing structure and possesses a potent inhibitory effect on ACE, with an IC50 of 0.025 μM. Captopril EP Impurity C is primarily utilized in quality control and method validation for pharmaceutical formulations of Captopril, providing essential insights into purity and compound stability in research contexts. -
Drug Impurity
1,2-Diacetylhydrazine, also known as N,N'-Diacetylhydrazine, functions primarily as a drug impurity. This compound can be utilized in analytical and quality control studies to evaluate the purity of pharmaceutical products and to assess potential safety profiles. Its presence may also be significant in the context of metabolic studies and toxicological assessments related to hydrazine derivatives. -
Fluticasone Dimer Impurity
Fluticasone dimer impurity is a dimeric form of Fluticasone Propionate, a potent corticosteroid known for its high affinity for glucocorticoid receptors. This impurity may be of interest in investigations related to the stability, purity, and efficacy of Fluticasone formulations. Its assessment can be essential for ensuring quality control in pharmaceutical development and research on corticosteroid activity. -
Carbocisteine Impurity
Carbocysteine sulfoxide is a metabolite and an impurity associated with carbocisteine. This compound is primarily utilized in chemical research to study its effects and interactions within biological systems. Its role as an impurity may provide insights into the metabolic pathways and biochemical properties of carbocisteine, enhancing our understanding of this compound's pharmacological profile. -
Risperidone Impurity
Risperidone E-oxime is a recognized impurity of Risperidone, primarily targeting serotonin 5-HT2 receptors and dopamine D2 receptors. This compound acts as a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, exhibiting inhibition constants (Kis) of 4.8 nM and 5.9 nM, respectively. It is particularly relevant for studies involving antipsychotic drug development, pharmacokinetics, and the assessment of metabolite profiles. -
Aceclofenac Impurity
Aceclofenac ethyl ester is an impurity of the non-steroidal anti-inflammatory drug Aceclofenac, primarily acting through inhibition of cyclooxygenase (COX) enzymes. This compound may serve as a reference standard in pharmacokinetic studies and method development for analyzing Aceclofenac and its related substances. Its characterization contributes to the understanding of the drug's stability and metabolism, aiding in the overall evaluation of therapeutic efficacy and safety profiles. -
Exenatide Impurity
(D-Asn28)-Exenatide is an impurity of Exenatide, which functions as a long-acting agonist of the glucagon-like peptide-1 receptor. This compound may be used in research applications focusing on peptide synthesis, quality control, and pharmacological studies involving GLP-1 receptor pathways. Its significance lies in understanding the properties and effects of Exenatide-related compounds. -
Budesonide Impurity
Budesonide impurity C is a known impurity associated with Budesonide, a potent inhaled corticosteroid that acts as an agonist of the glucocorticoid receptor. This impurity may play a role in studying the pharmacological profiles and quality control of Budesonide formulations. It is relevant for research applications involving drug stability, metabolism, and the assessment of therapeutic efficacy in inflammatory conditions. -
Prednisolone Impurity
Prednisolone valerate acetate is a known impurity of Prednisolone, a potent, orally active corticosteroid that primarily functions as a glucocorticoid. This compound is relevant for research focused on corticosteroid metabolism and any potential side effects associated with glucocorticoid therapies. Its presence may be significant in the analysis of pharmaceutical formulations containing Prednisolone and supports studies investigating corticosteroid-related biological activity. -
Impurity
6-Iododiosmin is a known impurity of Diosmin, serving as a reference standard for the characterization of Diosmin-related compounds. It is essential for quality control in pharmaceutical formulations and research involving Diosmin's therapeutic applications. This compound aids in the investigation of the chemical behavior and biological properties of Diosmin, thereby enhancing the understanding of its efficacy and safety profiles. -
Arginine Impurity
2-Oxoarginine (α-keto-δ-Guanidinovaleric acid) is a notable impurity of arginine, characterized by its ketone functionality. This compound is often utilized in biochemical research to study arginine metabolism and its associated pathways. Due to its structural similarity to arginine, 2-Oxoarginine can serve as a useful reference standard in analytical chemistry and formulation development. -
Impurity of Rivaroxaban
Rivaroxaban EP Impurity I is an impurity associated with Rivaroxaban, a selective and potent inhibitor of Factor Xa (FXa). This reagent can be utilized in quality control processes to ensure the purity of Rivaroxaban in pharmaceutical formulations. Its analytical applications are crucial for the assessment of Rivaroxaban's purity and compliance with regulatory standards. -
Zopiclone Impurity
Deschloro-Zopiclone is an impurity of Zopiclone, the first non-benzodiazepine compound that enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. This compound is relevant for studies focused on the pharmacological profiles and safety assessments of Zopiclone. It can be utilized in research related to sleep disorders and the analysis of medication impurities. -
Impurity
Pregabalin diacid is characterized as an impurity of Pregabalin, a lipophilic analog of GABA (γ-aminobutyric acid) with notable anxiolytic and anticonvulsant properties. Its primary mechanism involves interaction with the α(2)β subunit of voltage-gated calcium channels, which are prevalent in both the peripheral and central nervous systems. Pregabalin is known to effectively induce hypoalgesia and enhance the management of behavioral disorders, making this impurity relevant in the context of quality control and pharmacological research. -
Cytochrome P450 Inhibitor
Verapamil EP Impurity C hydrochloride is a known impurity of Verapamil, primarily acting as a Cytochrome P450 inhibitor. This compound exhibits significant biological activity as a calcium channel blocker, contributing to its role as a first-generation P-glycoprotein (P-gp) inhibitor. Its utility in research includes studies on drug metabolism, pharmacokinetics, and interactions with P-gp transporters, making it a valuable reagent for pharmacological investigations. -
Impurity of Pantoprazole
N3-Methyl pantoprazole is an impurity of the proton pump inhibitor Pantoprazole. It serves as a significant reference standard for quality control and analytical research in pharmaceutical development. Its characterization aids in understanding the metabolic pathways and stability of Pantoprazole, providing insight into the safety and efficacy profiles of related compounds. This reagent is essential for researchers examining the pharmacological aspects of proton pump inhibitors. -
Clopidogrel Impurity
Clopidogrel-related Compound B hydrochloride is an impurity of Clopidogrel, functioning as a pharmacological marker in analytical applications. Its presence is an important consideration in the assessment of Clopidogrel purity and efficacy. This compound is primarily utilized in pharmaceutical research to ensure the quality and consistency of Clopidogrel formulations. -
Impurity of Darifenacin
(±)-Darifenacin N-Oxide is an impurity of the selective M3 muscarinic receptor antagonist Darifenacin. This compound may serve as a reference standard in analytical chemistry and pharmacological studies involving Darifenacin. Its characterization is crucial for ensuring the purity and efficacy of Darifenacin in various research applications. -
Ziprasidone Impurity
6-Chloro-5-(2-chloroethyl)oxindole is a known impurity of Ziprasidone, which primarily targets the human dopamine transporter (hDAT). This compound serves as an important reference standard for assessing the purity of Ziprasidone in pharmaceutical research. It is utilized in studies related to dopaminergic activity and may aid in the development of antipsychotic medications. -
Impurity of Sirolimus
Sirolimus isomer C is an impurity of Sirolimus, a macrolide compound that acts through the inhibition of the mammalian target of rapamycin (mTOR). This compound is primarily used for quality control assessments and method development in pharmaceuticals. Its characterization is crucial for ensuring the purity and efficacy of Sirolimus formulations in research and clinical applications. -
Impurity
1-Methyl-4-nitrosopiperazine is a known impurity associated with sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics. Its presence in pharmaceutical formulations is of significant concern due to potential safety implications. This compound is commonly utilized in research to study impurity profiles and ensure the efficacy and safety of drug products. -
Drug Impurity
(1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride is a chemical compound often encountered as a drug impurity. Its primary target is related to its role in the synthesis and analysis of various pharmaceutical formulations. This reagent is utilized in research applications focused on evaluating drug purity, stability, and potential biological impacts of impurities in pharmacological studies.
