Catalog No.
Product Name
Application
Product Information
Citations
-
Captopril Impurity
Captopril EP Impurity C is a known impurity of the antihypertensive agent Captopril, a competitive angiotensin-converting enzyme (ACE) inhibitor. This compound is characterized by its thiol-containing structure and possesses a potent inhibitory effect on ACE, with an IC50 of 0.025 μM. Captopril EP Impurity C is primarily utilized in quality control and method validation for pharmaceutical formulations of Captopril, providing essential insights into purity and compound stability in research contexts. -
Drug Impurity
1,2-Diacetylhydrazine, also known as N,N'-Diacetylhydrazine, functions primarily as a drug impurity. This compound can be utilized in analytical and quality control studies to evaluate the purity of pharmaceutical products and to assess potential safety profiles. Its presence may also be significant in the context of metabolic studies and toxicological assessments related to hydrazine derivatives. -
Fluticasone Dimer Impurity
Fluticasone dimer impurity is a dimeric form of Fluticasone Propionate, a potent corticosteroid known for its high affinity for glucocorticoid receptors. This impurity may be of interest in investigations related to the stability, purity, and efficacy of Fluticasone formulations. Its assessment can be essential for ensuring quality control in pharmaceutical development and research on corticosteroid activity. -
Carbocisteine Impurity
Carbocysteine sulfoxide is a metabolite and an impurity associated with carbocisteine. This compound is primarily utilized in chemical research to study its effects and interactions within biological systems. Its role as an impurity may provide insights into the metabolic pathways and biochemical properties of carbocisteine, enhancing our understanding of this compound's pharmacological profile. -
Risperidone Impurity
Risperidone E-oxime is a recognized impurity of Risperidone, primarily targeting serotonin 5-HT2 receptors and dopamine D2 receptors. This compound acts as a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, exhibiting inhibition constants (Kis) of 4.8 nM and 5.9 nM, respectively. It is particularly relevant for studies involving antipsychotic drug development, pharmacokinetics, and the assessment of metabolite profiles. -
Eszopiclone Impurity
RP 48497 is a photodegradation product and impurity of Eszopiclone, a non-benzodiazepine compound utilized in the management of insomnia. This compound serves as a valuable tool in pharmaceutical research and quality control, aiding in the assessment of Eszopiclone's stability and purity. Its analysis can contribute to a deeper understanding of the drug's degradation pathways and potential effects on efficacy and safety. -
Fexofenadine Impurity
Meta-Fexofenadine is a known impurity of Fexofenadine, which serves as an antihistamine by targeting the H1 receptor (H1R) and is primarily utilized for the treatment of allergic conditions such as seasonal allergic rhinitis and chronic idiopathic urticarial. This compound can be critical for analytical research, particularly in the study of drug purity, metabolic pathways, and formulation development. Its presence is significant in ensuring the quality and safety of Fexofenadine-based therapeutic products. -
Nifedipine Impurity
m-Nifedipine is an impurity associated with Nifedipine, a well-known calcium channel blocker. Nifedipine primarily targets L-type calcium channels, resulting in the relaxation of vascular smooth muscle, which is beneficial in the treatment of cardiac insufficiencies and hypertension. The study of m-Nifedipine may provide insights into the stability, quality, and potential side effects of Nifedipine formulations in pharmaceutical research. -
Impurity of Methotrexate
1,1,3-Tribromoacetone is identified as an impurity of Methotrexate, an established antimetabolite and antifolate that targets dihydrofolate reductase. By inhibiting this enzyme, Methotrexate effectively disrupts the conversion of folic acid to tetrahydrofolate, leading to a significant reduction in DNA synthesis. This compound can be utilized in the study of Methotrexate's pharmacological profiles and potential impurities in biological research. -
Impurity of Palbociclib
N-Methyl Palbociclib is an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound is primarily used in analytical studies to assess the purity and quality of Palbociclib formulations. Its relevance in research includes characterization of CDK inhibition and investigations into cell cycle regulation in cancer therapy. -
Impurity of Febuxostat
Febuxostat amide impurity is a known impurity associated with the compound Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. The presence of this impurity can be significant for analytical applications and the assessment of the purity in pharmaceutical formulations. It serves as an important reference material for researchers investigating the chemical integrity and efficacy of xanthine oxidase inhibitors in various biological contexts. -
Osimertinib Mesylate Impurity
Rezivertinib analogue 1 is recognized as a process impurity of osimertinib mesylate, a potent inhibitor of EGFR mutations. This compound serves as a valuable tool in the research of non-small cell lung cancer, facilitating the investigation of drug efficacy and safety profiles in therapeutic applications. Its role in characterizing impurities enhances understanding of the pharmacological landscape surrounding osimertinib-related treatments. -
Labetalol Impurity
Labetalone hydrochloride is an impurity of Labetalol, an orally active adrenoceptor blocking agent. It functions as a competitive antagonist at both alpha- and beta-adrenoceptor sites, contributing to the pharmacological profile of Labetalol. This compound is primarily used in research applications related to cardiovascular pharmacology and the study of adrenoceptor interactions. -
Febuxostat Impurity
Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts. -
Atorvastatin Impurity
Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases. -
Venetoclax Impurity
Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity. -
Cetirizine Impurity
Deschloro Cetirizine dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine and a carboxylated metabolite of hydroxyzine. This compound acts as a selective and orally active histamine H1-receptor antagonist, exhibiting long-lasting antihistaminic effects. It is primarily used in biochemical research aimed at understanding the purity and composition of antihistamine formulations. -
Gefitinib Impurity
Gefitinib impurity 5 is a chemical impurity associated with Gefitinib, a selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. This compound effectively inhibits EGF-stimulated tumor cell proliferation (IC50 of 54 nM) and blocks EGFR autophosphorylation in tumor cells, contributing to its antitumor efficacy. Additionally, Gefitinib has been shown to induce autophagy, making it a valuable reagent for research in cancer biology and drug development. -
Acetaminophen Impurity
4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations. -
Linezolid Impurity
(R)-Linezolid is an impurity associated with Linezolid (PNU-100766), the first oxazolidinone-synthetic antibiotic. It functions by inhibiting the initiation phase of bacterial protein synthesis, effectively targeting various gram-positive bacteria. This reagent is valuable for research focused on antibiotic characterization, development of new antibacterial agents, and understanding resistance mechanisms. -
Rapamycin Impurity
28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases. -
Impurity of Febuxostat
Febuxostat dicarboxylic acid impurity is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. This impurity is utilized in chemical analysis and quality control processes in the pharmaceutical industry to ensure the purity and efficacy of Febuxostat formulations. Its characterization is crucial for compliance with regulatory standards and for optimizing drug development protocols. -
Impurity
Captopril EP Impurity D is identified as an impurity associated with Captopril, an angiotensin-converting enzyme (ACE) inhibitor. It serves as a reference standard in pharmaceutical quality control and analytical testing to ensure the purity and compliance of Captopril formulations. This compound is critical for researchers monitoring the chemical profile and safety of ACE inhibitors in drug development and therapeutic applications. -
Chlorthalidone Impurity
Chlorthalidone impurity is a metabolite of the thiazide-like diuretic Chlorthalidone, primarily targeting sodium reabsorption in the renal tubules. This impurity is important for studies involving metabolic pathways and pharmacokinetics of Chlorthalidone. It is particularly relevant for research into hypertension treatment and the identification of potential off-target effects or interactions. -
Vardenafil Impurity
Vardenafil N-oxide is an N-Oxide impurity of Vardenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor. This compound serves as an important analytical standard for quality control and characterization of Vardenafil formulations in pharmaceutical research. Its presence may impact the pharmacokinetics and efficacy of Vardenafil, making it relevant for studies on drug metabolism and safety assessments. -
Simvastatin Impurity
Anhydrosimvastatin is an impurity of Simvastatin, a known competitive inhibitor of HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. This compound is primarily used in research to assess the purity and quality of Simvastatin preparations. Its characterization is essential for studies evaluating the pharmaceutical formulations and metabolic pathways influenced by cholesterol-lowering therapies. -
Trityl olmesartan medoxomil Impurity
Trityl olmesartan medoxomil impurity III is a characterized impurity of Trityl olmesartan medoxomil, which itself serves as an intermediate in the synthesis of Olmesartan medoxomil. This compound is utilized in chemical research to evaluate the purity of olmesartan formulations and assess related synthesis methods. Its presence as an impurity is crucial for understanding the intricacies of drug development and quality control processes within the pharmaceutical industry. -
Atorvastatin Impurity
Difluoro atorvastatin is an impurity of the HMG-CoA reductase inhibitor atorvastatin. This compound demonstrates significant activity by effectively reducing blood lipid levels. Additionally, difluoro atorvastatin is known to inhibit the proliferation and invasion of human smooth muscle cells, exhibiting IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a useful reference compound in the evaluation of atorvastatin purity and related studies in cholesterol management and cardiovascular research. -
Febuxostat Impurity
Febuxostat impurity 7 is a chemical impurity related to Febuxostat, a selective xanthine oxidase inhibitor with a Ki value of 0.6 nM. This impurity is important for quality control and characterization in drug development and analytical chemistry applications involving Febuxostat. Understanding its properties can aid in assessing the purity and stability of formulations containing Febuxostat. -
Daclatasvir Impurity
Daclatasvir Impurity C is a chemical impurity associated with Daclatasvir, a potent inhibitor of the Hepatitis C virus (HCV) NS5A protein. Its characterization is essential for assessing the purity and quality of Daclatasvir in pharmaceutical formulations. This reagent is valuable for researchers focusing on the pharmacological properties of antiviral compounds and for ensuring compliance in drug development processes. -
Hydroxychloroquine Impurity
Hydroxychloroquine Impurity F is a structural impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. This compound demonstrates the ability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling pathways. Hydroxychloroquine has also been shown to effectively inhibit SARS-CoV-2 infection in vitro, making it a significant focus of research in virology and immunology. -
Prasugrel Impurity
Prasugrel chloride impurity is a chemical impurity associated with Prasugrel, extracted from patent US20130345428A1, line 0053. Prasugrel serves as a potent and orally active antagonist of the P2Y12 receptor, effectively inhibiting ADP-induced platelet aggregation. This reagent is useful for research applications related to platelet function and thrombotic disorders, aiding in the assessment of drug purity and compliance in pharmaceutical formulations. -
Impurity of Cetirizine 3-chloro
Cetirizine 3-chloro impurity is a structural variant of Cetirizine 3-chloro, primarily analyzed for its potential effects on pharmacological activity. As an impurity, it is relevant in various quality control and analytical chemistry applications when assessing the purity of Cetirizine formulations. The characterization of this impurity is essential for ensuring the safety and efficacy of related pharmaceutical products. -
Atorvastatin Impurity
3-Oxo Atorvastatin is an impurity of atorvastatin, which acts as an HMG-CoA reductase inhibitor. This compound is critical in studying the metabolic pathways associated with cholesterol synthesis and lipid regulation. Its role as an impurity is essential for accurately assessing the purity and efficacy of atorvastatin in pharmaceutical formulations and research applications. -
Remdesivir Impurity
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of the antiviral agent Remdesivir, a nucleoside analogue primarily targeting viral RNA synthesis. This compound is relevant in assessing the purity and efficacy of Remdesivir, which has demonstrated potent antiviral activity against SARS-CoV and MERS-CoV, with EC50 values of 74 nM in human airway epithelial cells and 30 nM against murine hepatitis virus in delayed brain tumor cells. Research involving this impurity can aid in the development and validation of antiviral therapeutics, particularly in the context of COVID-19. -
Gefitinib Impurity
Gefitinib impurity 1 is a known impurity associated with the tyrosine kinase inhibitor gefitinib, which specifically targets the epidermal growth factor receptor (EGFR). This compound plays a role in research applications aimed at understanding gefitinib's mechanism of action and its effects on EGF-stimulated tumor cell proliferation. Gefitinib demonstrates a potent inhibitory effect on EGFR autophosphorylation and tumor cell growth, making it valuable for studies related to cancer therapeutics and the exploration of resistance mechanisms in oncological research. -
Macamide Impurity
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a known impurity of Macamide, primarily utilized in the study of lipid metabolism and signaling pathways. This compound can be valuable for researchers investigating the biological effects of macamide derivatives and their potential role in modulating cellular processes. Its distinct chemical structure allows for the exploration of its impacts on various biological systems. -
Drug Impurity
Clozapine impurity 3 is a known impurity associated with the antipsychotic agent Clozapine. It serves as a critical reference material for assessing the purity and quality of Clozapine formulations. This reagent is essential for research and analytical applications focused on drug development, impurity profiling, and safety assessments of pharmaceutical compounds. -
Cetilistat Impurity
Cetilistat impurity 1 is a known impurity of the anti-obesity agent Cetilistat, which inhibits pancreatic lipase. This compound demonstrates significant biological activity, inhibiting both rat and human pancreatic lipase with IC50 values of 54.8 nM and 5.95 nM, respectively. It is primarily utilized in research to assess the purity and efficacy of Cetilistat and related formulations in obesity-related studies. -
Daclatasvir Impurity
Daclatasvir Impurity B is an impurity of the antiviral agent Daclatasvir, which targets the HCV NS5A protein. This compound is significant for quality control and analytical purposes in the synthesis and formulation of Daclatasvir. It may also be utilized in research applications aimed at understanding the pharmacological properties and stability of Daclatasvir. -
Impurity of Pantoprazole
N3-Methyl pantoprazole is an impurity of the proton pump inhibitor Pantoprazole. It serves as a significant reference standard for quality control and analytical research in pharmaceutical development. Its characterization aids in understanding the metabolic pathways and stability of Pantoprazole, providing insight into the safety and efficacy profiles of related compounds. This reagent is essential for researchers examining the pharmacological aspects of proton pump inhibitors. -
Zopiclone Impurity
Deschloro-Zopiclone is an impurity of Zopiclone, the first non-benzodiazepine compound that enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. This compound is relevant for studies focused on the pharmacological profiles and safety assessments of Zopiclone. It can be utilized in research related to sleep disorders and the analysis of medication impurities. -
Impurity
Pregabalin diacid is characterized as an impurity of Pregabalin, a lipophilic analog of GABA (γ-aminobutyric acid) with notable anxiolytic and anticonvulsant properties. Its primary mechanism involves interaction with the α(2)β subunit of voltage-gated calcium channels, which are prevalent in both the peripheral and central nervous systems. Pregabalin is known to effectively induce hypoalgesia and enhance the management of behavioral disorders, making this impurity relevant in the context of quality control and pharmacological research. -
Cytochrome P450 Inhibitor
Verapamil EP Impurity C hydrochloride is a known impurity of Verapamil, primarily acting as a Cytochrome P450 inhibitor. This compound exhibits significant biological activity as a calcium channel blocker, contributing to its role as a first-generation P-glycoprotein (P-gp) inhibitor. Its utility in research includes studies on drug metabolism, pharmacokinetics, and interactions with P-gp transporters, making it a valuable reagent for pharmacological investigations. -
Impurity of Rivaroxaban
Rivaroxaban EP Impurity I is an impurity associated with Rivaroxaban, a selective and potent inhibitor of Factor Xa (FXa). This reagent can be utilized in quality control processes to ensure the purity of Rivaroxaban in pharmaceutical formulations. Its analytical applications are crucial for the assessment of Rivaroxaban's purity and compliance with regulatory standards. -
Arginine Impurity
2-Oxoarginine (α-keto-δ-Guanidinovaleric acid) is a notable impurity of arginine, characterized by its ketone functionality. This compound is often utilized in biochemical research to study arginine metabolism and its associated pathways. Due to its structural similarity to arginine, 2-Oxoarginine can serve as a useful reference standard in analytical chemistry and formulation development. -
Impurity of Sirolimus
Sirolimus isomer C is an impurity of Sirolimus, a macrolide compound that acts through the inhibition of the mammalian target of rapamycin (mTOR). This compound is primarily used for quality control assessments and method development in pharmaceuticals. Its characterization is crucial for ensuring the purity and efficacy of Sirolimus formulations in research and clinical applications. -
Ziprasidone Impurity
6-Chloro-5-(2-chloroethyl)oxindole is a known impurity of Ziprasidone, which primarily targets the human dopamine transporter (hDAT). This compound serves as an important reference standard for assessing the purity of Ziprasidone in pharmaceutical research. It is utilized in studies related to dopaminergic activity and may aid in the development of antipsychotic medications. -
Impurity
1-Methyl-4-nitrosopiperazine is a known impurity associated with sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics. Its presence in pharmaceutical formulations is of significant concern due to potential safety implications. This compound is commonly utilized in research to study impurity profiles and ensure the efficacy and safety of drug products. -
Clindamycin Impurity
7-Epiclindamycin is an impurity associated with Clindamycin, primarily generated during the synthesis process of this antibiotic. Its presence can impact the purity and efficacy of the final product. Research applications typically focus on characterizing impurities in pharmaceutical compounds and optimizing synthesis pathways to enhance drug quality.
