P2X3 antagonist 34 is a selective and orally active antagonist targeting the P2X3 homotrimeric receptor, demonstrating IC50 values of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors, respectively. This compound exhibits reduced activity against P2X2/3 heterotrimeric receptors, indicating a favorable selectivity profile. Its significant anti-tussive properties make P2X3 antagonist 34 a valuable tool for research in pain and respiratory conditions.
P2X3 antagonist 34 is a selective and orally active antagonist targeting the P2X3 homotrimeric receptor, demonstrating IC50 values of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors, respectively. This compound exhibits reduced activity against P2X2/3 heterotrimeric receptors, indicating a favorable selectivity profile. Its significant anti-tussive properties make P2X3 antagonist 34 a valuable tool for research in pain and respiratory conditions.
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