P2X7 receptor antagonist-6

Catalog No.: A67937
P2X7 Receptor Antagonist
P2X7 receptor antagonist-6 is a negative allosteric modulator targeting the P2X7 receptor, exhibiting an IC50 of 1.31 μM for human P2X7. This compound demonstrates potential for research applications in cancer, neurodegenerative disorders, inflammatory responses, and infectious diseases, contributing to a greater understanding of P2X7's role in these conditions. Its specificity and efficacy make it a valuable tool for exploring therapeutic pathways in related research fields.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionP2X7 receptor antagonist-6 is a negative allosteric modulator targeting the P2X7 receptor, exhibiting an IC50 of 1.31 μM for human P2X7. This compound demonstrates potential for research applications in cancer, neurodegenerative disorders, inflammatory responses, and infectious diseases, contributing to a greater understanding of P2X7's role in these conditions. Its specificity and efficacy make it a valuable tool for exploring therapeutic pathways in related research fields.
Product Information
Catalog NumA67937
FormulaC23H20F2N2O3
Molecular Weight410.41
CAS Number1114621-31-6
SMILESO=C(NC(CC1=CC=C(C=C1)F)CC2=CC=C(C=C2)F)NC3=CC4=C(OCO4)C=C3
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