P300-IN-6 is an orally bioavailable inhibitor targeting the histone acetyltransferase p300 HAT domain, exhibiting a human IC50 of 7 nM. This compound effectively suppresses c-Myc expression and reduces acetylation levels of histones H3K18 and H3K27, leading to inhibition of cancer cell proliferation. P300-IN-6 demonstrates significant antitumor activity in xenograft mouse models, making it a valuable tool for investigating therapeutic strategies in multiple myeloma research.
P300-IN-6 is an orally bioavailable inhibitor targeting the histone acetyltransferase p300 HAT domain, exhibiting a human IC50 of 7 nM. This compound effectively suppresses c-Myc expression and reduces acetylation levels of histones H3K18 and H3K27, leading to inhibition of cancer cell proliferation. P300-IN-6 demonstrates significant antitumor activity in xenograft mouse models, making it a valuable tool for investigating therapeutic strategies in multiple myeloma research.
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