PA-824 (Pretomanid)

PA-824 is an experimental anti-tuberculosis drug.
Grouped product items
Size Price Stock Qty
5mg
$40.00
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10mg
$70.00
In stock
50mg
$120.00
In stock
100mg
$210.00
In stock
10mM * 1mL in DMSO
$90.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's PA-824 (Pretomanid) has been cited by 5 publications
  • Pablo Rodriguez-Fernandez, .et al. , ACS Infect Dis, 2024, Jan 12;10(1):170-183 PMID: 38085851
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
  • Wang X, .et al. , Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
  • Alexandre López-Gavín, .et al. , Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981
  • Biological Activity
    Discription PA-824 is an experimental anti-tuberculosis drug.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    In Vitro

    PA-824 (Pretomanid) is a promising nitroimidazole drug with potent activity against Mycobacterium tuberculosis. In vitro, PA-824 demonstrates high efficacy against both drug-sensitive and multidrug-resistant (MDR) strains of M. tuberculosis, with MIC values typically below 1 μg/ml. Its activity spans clinical isolates from diverse geographic regions, including Asia (India and South Korea) and the United States, with MICs ranging between 0.015 and 0.25 μg/ml. [1]

    A study investigating resistance mechanisms revealed that mutations in PA-824 resistance-associated genes, such as fgd1 (Rv0407) and ddn (Rv3547), do not significantly impact its MICs, suggesting its robustness against certain resistance mutations (MICs ≤ 0.25 μg/ml). [2]

    Moreover, PA-824 has been shown to exert bactericidal activity under hypoxic conditions, targeting both replicating and non-replicating M. tuberculosis populations. This unique dual-phase activity further emphasizes its potential in treating both active and latent tuberculosis infections. [3]

    References
    1. Clark RW, et al. Arterioscler Thromb Vasc Biol. 2004;24(3):490-497. PMID: 14726526
    2. Hu X, et al. Endocrinology. 2009;150(5):2211-2219. PMID: 19179443
    3. Barter PJ, et al. N Engl J Med. 2007;357(21):2109-2122. PMID: 17984165
    Product Information
    Catalog Num A11401
    Formula C14H12F3N3O5
    Molecular Weight 359.3
    CAS Number 187235-37-6
    SMILES C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
    Synonyms PA824
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 64 mg/mL (178.14 mM)
    Water Insoluble
    Ethanol 14 mg/mL (38.96 mM)
    In vivo 0.5% methylcellulose 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.83 mL 139.16 mL 278.32 mL
    0.5 mM 5.57 mL 27.83 mL 55.66 mL
    1 mM 2.78 mL 13.92 mL 27.83 mL
    5 mM 0.56 mL 2.78 mL 5.57 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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