PA-824 (Pretomanid)

Catalog No.: A11401

PA-824 (Pretomanid)

PA-824 (Pretomanid) Chemical Structure

CAS NO. 187235-37-6

PA-824 is an experimental anti-tuberculosis drug.

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5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $90.00

Special Price $72.00

50 mg

Regular Price: $200.00

Special Price $160.00

100 mg

Regular Price: $300.00

Special Price $240.00

10mM * 1mL in DMSO

Regular Price: $90.00

Special Price $72.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Wang X, .et al. Antitubercular Triazines: Optimization and Intrabacterial Metabolism, Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
  • Alexandre López-Gavín, .et al. In vitro activity against Mycobacterium tuberculosis of levofloxacin, moxifloxacin and UB-8902 in combination with clofazimine and pretomanid., Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981

Biological Activity

PA-824 is an experimental anti-tuberculosis drug.
Targets
tuberculosis
In vitro (25°C) DMSO 64 mg/mL (178.14 mM)
Water Insoluble
Ethanol 14 mg/mL (38.96 mM)
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.83 mL 139.16 mL 278.32 mL
0.5 mM 5.57 mL 27.83 mL 55.66 mL
1 mM 2.78 mL 13.92 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL

*The above data is based on the productmolecular weight 359.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11401
CAS No. 187235-37-6
Formula C14H12F3N3O5
M. Wt 359.3
Purity >98%
Synonyms PA824
SMILES C1[[email protected]@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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