PA-824 (Pretomanid)
Catalog No.: A11401
PA-824 is an experimental anti-tuberculosis drug.
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Adooq Products cited in reputable paper
Adooq's PA-824 (Pretomanid) has been cited by 5 publications
- Pablo Rodríguez-Fernández, .et al. , ACS Infect Dis, 2024, Jan 12;10(1):170-183 PMID: 38085851
- Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
- Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
- Wang X, .et al. , Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
- Alexandre López-Gavín, .et al. , Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981
Biological Activity
| Description | PA-824 is an experimental anti-tuberculosis drug. | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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| In Vitro | PA-824 (Pretomanid) is a promising nitroimidazole drug with potent activity against Mycobacterium tuberculosis. In vitro, PA-824 demonstrates high efficacy against both drug-sensitive and multidrug-resistant (MDR) strains of M. tuberculosis, with MIC values typically below 1 μg/ml. Its activity spans clinical isolates from diverse geographic regions, including Asia (India and South Korea) and the United States, with MICs ranging between 0.015 and 0.25 μg/ml. [1] A study investigating resistance mechanisms revealed that mutations in PA-824 resistance-associated genes, such as fgd1 (Rv0407) and ddn (Rv3547), do not significantly impact its MICs, suggesting its robustness against certain resistance mutations (MICs ≤ 0.25 μg/ml). [2] Moreover, PA-824 has been shown to exert bactericidal activity under hypoxic conditions, targeting both replicating and non-replicating M. tuberculosis populations. This unique dual-phase activity further emphasizes its potential in treating both active and latent tuberculosis infections. [3] | |||||
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Product Information
| Catalog Num | A11401 |
|---|---|
| Formula | C14H12F3N3O5 |
| Molecular Weight | 359.3 |
| CAS Number | 187235-37-6 |
| SMILES | C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F |
| Synonyms | PA824 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 64 mg/mL (178.14 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (38.96 mM) | ||
| In vivo | 0.5% methylcellulose | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.83 mL | 139.16 mL | 278.32 mL |
| 0.5 mM | 5.57 mL | 27.83 mL | 55.66 mL |
| 1 mM | 2.78 mL | 13.92 mL | 27.83 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.57 mL |
Useful Calculator
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