Pacritinib citrate is a selective inhibitor of Janus kinase 2 (JAK2), effective against both wild-type JAK2 (IC50 = 23 nM) and the JAK2V617F mutant (IC50 = 19 nM). In addition to its primary target, Pacritinib citrate also inhibits FLT3 and its mutant FLT3D835Y (IC50 = 22 nM and 6 nM, respectively). This compound is relevant for research focused on acute myeloid leukemia (AML) and myelofibrosis (MF), providing a valuable tool for elucidating the role of JAK2 and FLT3 in these hematological malignancies.
Pacritinib citrate is a selective inhibitor of Janus kinase 2 (JAK2), effective against both wild-type JAK2 (IC50 = 23 nM) and the JAK2V617F mutant (IC50 = 19 nM). In addition to its primary target, Pacritinib citrate also inhibits FLT3 and its mutant FLT3D835Y (IC50 = 22 nM and 6 nM, respectively). This compound is relevant for research focused on acute myeloid leukemia (AML) and myelofibrosis (MF), providing a valuable tool for elucidating the role of JAK2 and FLT3 in these hematological malignancies.
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